1. Distorted representations of age and gender are reflected in AI models

2. Drones switch payloads in mid-air using a flying toolbox

3. Sacrificial metal speeds up synthesis of nano-alloys from multiple elements

4. A quantum boost for ultra-precise clocks

5. Ultra-sensitive DNA sequencing maps mutations that precede cancer

6. Tracing the ancestry of barley in time and space

7. Brain area linked to chronic pain discovered — offering hope for treatments

8. Flexible perceptual encoding by discrete gamma events

9. Programmable on-chip nonlinear photonics

10. KCTD10 is a sensor for co-directional transcription–replication conflicts

11. Quantum-amplified global-phase spectroscopy on an optical clock transition

12. Sex and smoking bias in the selection of somatic mutations in human bladder

13. Southward impact excavated magma ocean at the lunar South Pole–Aitken basin

14. A ductile chromium–molybdenum alloy resistant to high-temperature oxidation

15. Sperm sequencing reveals extensive positive selection in the male germline

16. Efficient and accurate search in petabase-scale sequence repositories

17. Somatic mutation and selection at population scale

18. A full-featured 2D flash chip enabled by system integration

19. Age and gender distortion in online media and large language models

20. Hotspots of human mutation point to clonal expansions in spermatogonia

21. A parabrachial hub for need-state control of enduring pain

22. Enzyme specificity prediction using cross attention graph neural networks

23. Daily briefing: Physics Nobel for quantum tunnelling on a macroscopic scale

24. Daily briefing: Nobel Prize for discovery of ‘brake’ on immune system

25. The girl who used to be my sister

26. Low quality papers are flooding the cancer literature — can this AI tool help to catch them?

27. Clues to why the weight-loss condition cachexia arises when cancer occurs

28. Chemistry Nobel for scientists who developed massively porous ‘super sponge’ materials

29. AI models that lie, cheat and plot murder: how dangerous are LLMs really?

30. These immune cells won Nobel fame — can they solve autoimmune disease?

31. The rise of ‘nightmare bacteria’: antimicrobial resistance in six charts

32. The EU’s Horizon research fund needs to stay a defence-free zone

33. The 1975 discovery of long-lost letters between Albert Einstein and the astronomer Willem de Sitter

34. Groundbreaking quantum-tunnelling experiments win physics Nobel

35. Customizable AI systems that anyone can adapt bring big opportunities — and even bigger risks

36. Stop treating code like an afterthought: record, share and value it

37. Incentives accelerate progress on open access in Spain

38. Microbe discovery holds promise for sustainable biotechnology

39. Stop destructive fishing in marine protected areas

40. Insect biodiversity monitoring must be expanded

41. Prizes must recognize machine contributions to discovery

42. Volunteer scientists work ‘nights and weekends’ to guide vaccine advice in US

43. Wonder, empathy, life: why we called our pregnancy-diagnostic company Mirvie

44. Connecting the dots: I trace the history of the East Kolkata Wetlands

45. Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’

46. The cutting-edge medical approaches that could transform ageing

47. Jane Goodall obituary: pioneer primatologist who inspired generations of scientists

48. 27 things we wish we’d known when we started our PhDs

49. Daily briefing: The Nobel prizes’ most prestigious rivals

50. From fossil fuels to ‘green capitalism’: the dilemmas of a just energy transition

51. Will AI ever win its own Nobel? Some predict a prize-worthy science discovery soon

52. A scientist’s guide to AI agents — how could they help your research?

53. Creative hobbies could slow brain ageing at the molecular level

54. ‘Rogue’ planet is fastest-growing ever observed

55. Weaponizing uncertainty in science and in public health puts people in harm’s way

56. First human transplant of kidney modified to have ‘universal’ blood type

57. Author Correction: Ribonucleotide incorporation into mitochondrial DNA drives inflammation

58. These science prizes want to rival the Nobels: how do they compare?

59. Marcus kinetics control singlet and triplet oxygen evolving from superoxide

60. The child of humanity becomes the mother of all

61. AI has designed thousands of potential antibiotics. Will any work?

62. Violin therapy: Books in brief

63. Daily briefing: ‘A messenger of hope’ — Jane Goodall’s impact on science

64. These alien planets are astronomers’ favourites: here’s why

65. Biothreat hunters catch dangerous DNA before it gets made

66. Scooped by a cupcake business: why we called our green-cement company Sublime Systems

67. Author Correction: EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells

68. Research assessment: a round-up for early-career researchers

69. Publisher Correction: Multimodal cell maps as a foundation for structural and functional genomics

70. Keep, lose, add: a checklist for plotting your next career move in science

71. Memorable, distinctive, not too ‘sciencey’: why we named our biotech firm Anocca

72. Exclusive: ex-CDC director talks about why she was fired

73. Model organism databases face budget cuts and closures

74. Jane Goodall’s legacy: three ways she changed science

75. Daily briefing: Fireworks in space — the month’s best science images

76. This US government shutdown is different: what it means for science

77. DNA circuits store data — with heat as their power source

78. Early- and late-diagnosed autism are genetically distinct

79. Parachutes inspired by the Japanese art of kirigami

80. Bacteria use a decoy defence molecule to set a trap for viruses

81. Ancient viral DNA in the human genome shapes early development

82. Quantum correlations enhance the sensitivity of room-temperature sensors

83. Features of autism can affect age of diagnosis – and so can genes

84. Machine learning matches enzymes with molecular substrates

85. Mix-and-match fossils tell the tale of snake and lizard evolution

86. A pathway that controls conversion of the amino acid cysteine into a cholesterol regulator

87. Elaborate machinery for inserting proteins into the outer membrane of bacteria

88. Evolution of drug-resistant ovarian-cancer clones tracked in patients

89. End GDP mania: how the world should really measure prosperity

90. Spin squeezing in an ensemble of nitrogen–vacancy centres in diamond

91. Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis

92. Long-distance remote epitaxy

93. A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling

94. The Panoptes system uses decoy cyclic nucleotides to defend against phage

95. A human-specific regulatory mechanism revealed in a pre-implantation model

96. Doughnut of social and planetary boundaries monitors a world out of balance

97. Mosaic anatomy in an early fossil squamate

98. Connecting chemical and protein sequence space to predict biocatalytic reactions

99. Tracking clonal evolution during treatment in ovarian cancer using cell-free DNA

100. Polygenic and developmental profiles of autism differ by age at diagnosis

101. Monoclonal antibodies protect against pandrug-resistant Klebsiella pneumoniae

102. Heat-rechargeable computation in DNA logic circuits and neural networks

103. Signal amplification in a solid-state sensor through asymmetric many-body echo

104. A new paradigm for outer membrane protein biogenesis in the Bacteroidota

105. Dietary cysteine enhances intestinal stemness via CD8 T cell-derived IL-22

106. Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death

107. Kirigami-inspired parachutes with programmable reconfiguration

108. Proteotoxic stress response drives T cell exhaustion and immune evasion

109. These laser-cut discs turn into super precise parachutes

110. Ancient viral DNA helps human embryos develop

111. Author Correction: Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy

112. HELIOS: a microcosm of Asian health with global reach

113. China’s research hospitals push for prominence

114. A guide to the Nature Index

115. Uniting Africa’s longitudinal cohorts

116. Fixing the imbalance in cancer rates between Black and white women

117. Hospitals have long been key for research, now their influence is broadening

118. How research hospitals are meeting the world’s health challenges

119. The devourer of trust

120. AI uses medical records to accurately predict onset of disease 20 years into the future

121. Gut microbiota keeps watch over future egg cells

122. Will your study change the world? This AI tool predicts the impact of your research

123. Six journal rejections and a major rethink: why I’m happy to admit to my research failures, and you should too

124. Trees of the Amazon are becoming even mightier

125. Daily briefing: Tiny charged bubbles of methane could explain will-o’-the-wisps

126. AI is dreaming up millions of new materials. Are they any good?

127. Saharan dust on the wind linked to hail in Europe

128. Death of a star leaves a legacy for exoplanets

129. Author Correction: Crystal structure of heliorhodopsin

130. See space fireworks and lightning spaghetti — September’s best science images

131. Early efforts to understand the processes underlying bird migration

132. Trust in the sea-bed mining authority is fragile — here’s how to change that

133. How to get the best night’s sleep: what the science says

134. Technology leaders should ‘pay back’ society to support the common good

135. Add a ‘speculation box’ to research papers

136. Make cities more walkable, in the real world and in virtual reality

137. AI tools could reduce the appeal of predatory journals

138. India and Pakistan share flood risks and must combine solutions

139. Daily briefing: Rookie researchers boost disruptive science

140. NIH races to spend its 2025 grant money — but fewer projects win funding

141. Daily briefing: Universities made the modern world — now they must survive it

142. How to find the papers you need to read — and avoid the ones you don’t

143. Power and profit drive what we eat: here’s why the food system needs a revolution

144. Rookie scientists make research teams more innovative

145. Public trust in science has declined since COVID — virologists need to unite around safety standards

146. How money, politics and technology are redefining the PhD experience in 2025

147. Little urchins, mischievous molluscs: my life as a sea champion

148. Author Correction: Selenium-alloyed tellurium oxide for amorphous p-channel transistors

149. Publisher Correction: Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors

150. China pledges to cut emissions by 2035: what does that mean for the climate?

151. Audio long read: Autism is on the rise — what’s really behind the increase?

152. How autism research quietly advanced this week despite talk of Tyenol link

153. Mitochondria expel tainted DNA — spurring age-related inflammation

154. What happens if pregnant women stop taking Tylenol?

155. Daily briefing: How to live to 117

156. Common air pollutant has a secret weapon: bacterial toxins

157. Swapping old immune cells in the brain with fresh ones could treat disease

158. How passage through the Milky Way’s spiral arms altered our planet

159. Python, the movie! The programming language’s origin story comes to the silver screen

160. Huntington’s disease treated for first time using gene therapy

161. Mammoth challenge: why we called our de-extinction company Colossal Biosciences

162. Big mother whales have more daughters than sons

163. US serial killer case opens door to using cutting-edge DNA data in courts

164. Retractions can reshape scientists’ careers in unexpected ways

165. When life gets in the way of your meticulously-planned career in science

166. Why is autism really on the rise? What the science says

167. Daily briefing: ‘Thinky think before grabby grab’ — lab tips for science success

168. Trump’s 100K visa fee for foreign talent: how will it affect researchers?

169. It’s not wokeness — it’s human rights

170. Arousal reframed as an organism‑wide dynamic system

171. How a dangerous tick-borne virus sneaks into the brain

172. Machine learning reveals potential consequences of cuts to US research

173. What research might be lost after the NIH’s cuts? Nature trained a bot to find out

174. Arousal as a universal embedding for spatiotemporal brain dynamics

175. Jazzy jaw joints: evolutionary fine-tuning reveals unexpected bone connections in ancient predecessors of mammals

176. How universities came to be — and why they are in trouble now

177. A common chromosome fusion in humans explained

178. The great university shake-up: four charts show how global higher education is changing

179. Electrostatic-based transfer keeps 2D materials ultra-clean

180. She lived to 117: what her genes and lifestyle tell us about longevity

181. How a tick-borne virus enters human cells

182. A drug–diet combination could improve childhood cancer treatment

183. Universities are — and must continue to be — a force for good

184. Using short synthetic nucleic acids to probe genes in viruses that infect bacteria

185. The future of universities: a Nature special report

186. No lectures, exams, essays: inside a twenty-first-century university

187. Boosting immune cells to combat cancer using CRISPR engineering and large-scale in vivo testing

188. Climate change is reshaping fish communities in the United States

189. Universities under fire must harness more of the financial value they create

190. Robotic system takes chemistry into hyperspace

191. Universities must move with the times: how six scholars tackle AI, mental health and more

192. Engineered enzymes can suppress genome-editing errors

193. Low-overhead transversal fault tolerance for universal quantum computation

194. The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution

195. Electrostatic-repulsion-based transfer of van der Waals materials

196. In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

197. Protecting double Holliday junctions ensures crossing over during meiosis

198. The formation and propagation of human Robertsonian chromosomes

199. A haplotype-based evolutionary history of barley domestication

200. LRP8 is a receptor for tick-borne encephalitis virus

201. Reprogramming neuroblastoma by diet-enhanced polyamine depletion

202. Systematic discovery of CRISPR-boosted CAR T cell immunotherapies

203. Holliday junction–ZMM protein feedback enables meiotic crossover assurance

204. Isothermal solidification for high-entropy alloy synthesis

205. Proximal cooperative aerial manipulation with vertically stacked drones

206. Robot-assisted mapping of chemical reaction hyperspaces and networks

207. Collective homeostasis of condensation-prone proteins via their mRNAs

208. Design of facilitated dissociation enables timing of cytokine signalling

209. Volcanic crisis reveals coupled magma system at Santorini and Kolumbo

210. Diverging fish biodiversity trends in cold and warm rivers and streams

211. Tailoring polymer electrolyte solvation for 600 Wh kg1 lithium batteries

212. Ribonucleotide incorporation into mitochondrial DNA drives inflammation

213. Convergent evolution of diverse jaw joints in mammaliamorphs

214. SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer

215. Industry-compatible silicon spin-qubit unit cells exceeding 99% fidelity

216. The geoeconomic turn in decarbonization

217. A tweezer array with 6100 highly coherent atomic qubits

218. Tylenol is over 130 years old — why is it still the gold-standard painkiller?

219. Exclusive: RFK Jr cancelled mRNA research — but the US military is still funding it

220. A press release from just before the singularity

221. Daily briefing: No strong evidence backs up Trump’s claims about Tylenol and autism

222. Fighting climate change takes more than data — it needs wonder, love and hope

223. Trump team backs an unproven drug for autism — but does it work?

224. ‘Shake it off’: Taylor Swift’s changing voice shows how our accents evolve

225. It’s a new term: here are 99 lab hacks

226. Nerdy and easy to pronounce: why we chose Apheros as the name for our technology start-up firm

227. Journals infiltrated with ‘copycat’ papers that can be written by AI

228. A multimodal robotic platform for multi-element electrocatalyst discovery

229. Fossil fight: how Raymond Dart countered some unfair criticism

230. How can universities train the skilled workers of tomorrow?

231. The meaning behind the moniker: how to choose a science-company name that delights customers, colleagues and investors

232. Daily briefing: World’s first AI-designed viruses attack antibiotic-resistant bacteria

233. The mini placentas and ovaries revealing the basics of women’s health

234. Ebola outbreak in the DRC: why is it so deadly?

235. Combat the human-made causes of Spain’s wildfires

236. China’s private higher-education sector is at a turning point

237. Long-standing marine reserves need continued support

238. US investment in African food systems will have global benefits

239. Trump links autism and Tylenol: is there any truth to it?

240. The Moon is rusting — thanks to ‘wind’ blown all the way from Earth

241. Is this really the world''s largest mirror? Researchers put it to the test

242. Corpse flowers waft out stinky compounds as fast as landfills do

243. Decoding the redox behaviour of copper in Ullmann-type coupling reactions

244. Gestational diabetes linked to autism in study: what scientists say

245. Real-time molecular recorders expose the inner lives of cells

246. I deeply scan timber to reduce wasting this precious resource

247. What drove the rise of civilizations? A decades-long quest points to warfare

248. Author Correction: Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection

249. Daily briefing: Device senses silent speech without an invasive brain implant

250. Hotly anticipated US vaccine meeting ends with confusion — and a few decisions

251. Atomic ‘conveyor belt’ boosts power of quantum computer

252. Harvard vs Trump: research funds still mostly frozen despite court win

253. Apocalypse then: how cataclysms shaped human societies

254. Daily briefing: AI model can predict your risk of diseases years before you might get them

255. Author Correction: Clonal dynamics and somatic evolution of haematopoiesis in mouse

256. Publisher Correction: Functional synapses between neurons and small cell lung cancer

257. A Chinese AI tool can manage chronic disease — could it revolutionize health care?

258. World''s first AI-designed viruses a step towards AI-generated life

259. Reviving the past and designing the future: Books in brief

260. How a mentoring connection boosted my ambitions for a science career

261. Tipsy bats and perfect pasta: Ig Nobels celebrate ‘improbable’ research

262. Soft robot steers itself down the human airway

263. The ‘near-telepathic’ device that puts AI in your head

264. Wildfire smoke exposure and mortality burden in the US under climate change

265. Author Correction: A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome

266. Global warming amplifies wildfire health burden and reshapes inequality

267. Can AI chatbots trigger psychosis? What the science says

268. Two tools to help you achieve career success in science

269. Daily briefing: Can AI help us talk to animals?

270. Three ways ex-CDC chief says that Trump team is sidelining science

271. Wired for growth: neuron–tumour signalling in the lung and brain increases growth of a hard-to-treat cancer

272. Will the public support basic science? A new non-profit aims to find out

273. Years of hits to the head prime the brain for decline

274. Earth’s atmosphere took two billion years to become fully oxygenated

275. Bioelectronic implants built from rolled-up stretchy circuits

276. Pharmaceutical giants pull out of UK: why it matters for global science

277. Bespoke 3D printing adapted to features mapped using computer vision

278. Secrets of DeepSeek AI model revealed in landmark paper

279. AI can learn to show its workings through trial and error

280. People are more likely to cheat when they delegate tasks to AI

281. Bring us your LLMs: why peer review is good for AI models

282. Which diseases will you have in 20 years? This AI makes accurate predictions

283. A photonic chip enables ultrabroadband wireless communication

284. A surprising way to make heat in an unexpected part of fat cells

285. Caribbean coral reefs are threatened by rising seas

286. A domed pachycephalosaur from the early Cretaceous of Mongolia

287. Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

288. Co-option of an ancestral cloacal regulatory landscape during digit evolution

289. Learning the natural history of human disease with generative transformers

290. Delegation to artificial intelligence can increase dishonest behaviour

291. Structural basis for mTORC1 activation on the lysosomal membrane

292. DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

293. Reduced Atlantic reef growth past 2 C warming amplifies sea-level impacts

294. High-density soft bioelectronic fibres for multimodal sensing and stimulation

295. A room temperature rechargeable all-solid-state hydride ion battery

296. Myeloperoxidase transforms chromatin into neutrophil extracellular traps

297. Selective presynaptic inhibition of leg proprioception in behaving Drosophila

298. Covariation MS uncovers a protein that controls cysteine catabolism

299. Stratified wind from a super-Eddington X-ray binary is slower than expected

300. Atomic-scale imaging of frequency-dependent phonon anisotropy