1. Guinea-Bissau suspends a US-funded vaccine trial as African scientists question its motives

2. Marvellous microbes, memory and the multiverse: Books in brief

3. NIH ends support for some human fetal-tissue research – dismaying scientists

4. Exclusive: key NIH review panels due to lose all members by the end of 2026

5. Cancer might protect against Alzheimer’s — this protein helps explain why

6. Microplastic levels in the air have been overestimated, but are still a big concern

7. What your breath says about the bacteria in your gut

8. When two years of academic work vanished with a single click

9. ‘Bodies like ours aren’t considered in academia’

10. Canny cattle: at least one cow knows how to use tools

11. Daily briefing: Trump — one year in

12. Cause of vision loss discovered in overlooked genes

13. ‘Remote controlled’ proteins illuminate living cells

14. The biggest ‘Schrödinger’s cat’ yet — physicists put 7,000 atoms in superposition

15. Publisher Correction: Polyamine-dependent metabolic shielding regulates alternative splicing

16. Hand stencils in Indonesian cave are world’s oldest known artworks

17. An eye-popping discovery: early vertebrates had four eyes rather than two

18. Sending babies to nursery completely reshapes their microbiomes

19. A variety of early hominin species shared the Afar region of Ethiopia

20. Schrödinger’s cat just got bigger: quantum physicists create largest ever ‘superposition’

21. Illuminating how the bird inner retina works without oxygen solves a 350-year-old structural mystery

22. More than half of authors of leading research say funding is declining

23. Quantum effect observed for biggest objects yet

24. The transition from monocyte to tissue-resident macrophage requires DHPS

25. Atmospheric microplastic emissions from land and ocean

26. Convergent evolution of scavenger cell development at brain borders

27. Accretion bursts crystallize silicates in a planet-forming disk

28. Biological insights into schizophrenia from ancestrally diverse populations

29. Fibroblastic reticular cells direct the initiation of T cell responses via CD44

30. Fibre integrated circuits by a multilayered spiral architecture

31. Baby-to-baby strain transmission shapes the developing gut microbiome

32. Relatively warm deep-water formation persisted in the Last Glacial Maximum

33. Probing quantum mechanics with nanoparticle matter-wave interferometry

34. LetA defines a structurally distinct transporter family

35. Quantum spin resonance in engineered proteins for multimodal sensing

36. Dissecting gene regulatory networks governing human cortical cell fate

37. Common variation in meiosis genes shapes human recombination and aneuploidy

38. Large-scale dynamos driven by shear-flow-induced jets

39. Critical role for a high-plasticity cell state in lung cancer

40. Oxygen-free metabolism in the bird inner retina supported by the pecten

41. Ageing promotes microglial accumulation of slow-degrading synaptic proteins

42. The potential for bridgmanite megacrysts to drive magma ocean segregation

43. Predatory aggression evolved through adaptations to noradrenergic circuits

44. Identification of an allosteric site on the E3 ligase adapter cereblon

45. Four camera-type eyes in the earliest vertebrates from the Cambrian Period

46. Core–envelope miscibility in sub-Neptunes and super-Earths

47. Rock art from at least 67,800 years ago in Sulawesi

48. Pyramidal neurons proportionately alter cortical interneuron subtypes

49. Symmetry, microscopy and spectroscopy signatures of altermagnetism

50. Temporal tissue dynamics from a spatial snapshot

51. Extreme barocaloric effect at dissolution

52. Construction of complex and diverse DNA sequences using DNA three-way junctions

53. Afar fossil shows broad distribution and versatility of Paranthropus

54. Editorial Expression of Concern: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

55. Why teens with ADHD are so vulnerable to the perils of social media

56. Why ADHD goes undiagnosed in girls

57. ADHD treatments move beyond stimulants

58. Is paracetamol in pregnancy a risk factor for ADHD?

59. Six highlights from ADHD research

60. Untangling the connection between dopamine and ADHD

61. ADHD is on the rise, but why?

62. Publisher Correction: Multiple oestradiol functions inhibit ferroptosis and acute kidney injury

63. The rich stopped buying yachts the year time went on sale

64. Seven technologies to watch in 2026

65. AI and nuclear energy feature strongly in agenda-setting technologies for 2026

66. Daily briefing: The first documented case of tool use in cattle

67. Girls are starting puberty younger — why, and what are the risks?

68. US Congress set to reject Trump’s sweeping science budget cuts

69. The US is quitting 66 global agencies: what does it mean for science?

70. How much protein do you actually need?

71. Author Correction: Anthropogenic influences on major tropical cyclone events

72. US science after a year of Trump: what has been lost and what remains

73. Mistaken identity and the psychology of human recognition

74. ‘Shattered’: US scientists speak out about how Trump policies disrupted their careers

75. ‘Every aspect of my work life has changed’ — scientists reflect on a year of Trump

76. Fossil-fuel phase out is not enough: countries must remove atmospheric carbon

77. Study decision-making to understand how technology will affect behaviour

78. US funding cuts harm aspiring young scientists, too

79. To gain public trust, make art central to science communication

80. Daily briefing: Gifted dogs have word-learning skills on a par with human toddlers

81. Can ''toxic masculinity'' be measured? Scientists try to quantify controversial term

82. Publisher Correction: A fault-tolerant neutral-atom architecture for universal quantum computation

83. Editorial Expression of Concern: En passant neurotrophic action of an intermediate axonal target in the developing mammalian CNS

84. Collective intelligence for AI-assisted chemical synthesis

85. Author Correction: An autonomous laboratory for the accelerated synthesis of inorganic materials

86. Floating science stations: my month on a research vessel looking after buoys

87. Forget formalism: mathematics was built on infighting and emotional turmoil

88. I’m going to halve my publication output. You should consider slow science, too

89. ‘Greed is the iron cage of our times’ — why nationalism is here to stay

90. Daily briefing: Symbols on ancient pottery could be earliest evidence of mathematics

91. HPV vaccine could help to protect the unvaccinated against cervical cancer

92. Gifted dogs learn new words by overhearing humans

93. Climate trends influence transatlantic flight times

94. My PI is not offering any support or guidance on my PhD project, what should I do?

95. How do vaccine cutbacks affect public health? Ask Japan

96. Briefing Chat: Can NASA return rocks from Mars? And why dogs have long ears

97. Daily briefing: Cancer cells stay hidden using stolen mitochondria

98. Humanoid robots step up their game: how useful are the latest droids?

99. PhD students’ taste for risk mirrors their supervisors’

100. A ‘time capsule for cells’ stores the secret experiences of their past

101. Campus protests and civil disobedience: does academia have a problem with activism?

102. Making progress on global health will need high-quality evidence

103. Nationwide genetic screening proves effective at catching disease risk early

104. Daily briefing: Why ‘harmless’ germs can be deadly for some people

105. During the course of my PhD, I’ve been relearning how to rest

106. Why is flu so bad this year? Highly mutated variant offers answers

107. Wolf pup’s stomach yields DNA from one of world’s last surviving woolly rhinos

108. How ageing harms the body’s response to raging infection

109. US science in 2026: five themes that will dominate Trump’s second year

110. Ancient pottery reveals early evidence of mathematical thinking

111. Memories of items and their contexts are encoded by separate groups of human brain cells

112. Biosensors characterize the routes taken by receptors to different active states

113. Genomic clues to the origin of eukaryotic cells

114. Credit in research goes hand in hand with responsibility

115. Ageing rewires the body’s tolerance to infection

116. Mysterious ‘little red dots’ could be black holes in disguise

117. Stretchy organic LED devices with an ‘exciplex’ state are highly efficient

118. LLMs behaving badly: mistrained AI models quickly go off the rails

119. AI tools boost individual scientists but could limit research as a whole

120. Polyamine-dependent metabolic shielding regulates alternative splicing

121. Sub-zero Celsius elastocaloric cooling via low-transition-temperature alloys

122. Artificial intelligence tools expand scientists’ impact but contract science’s focus

123. Predictive coding of reward in the hippocampus

124. An electrically injected solid-state surface acoustic wave phonon laser

125. CFAP20 salvages arrested RNAPII from the path of co-directional replisomes

126. Language model-guided anticipation and discovery of mammalian metabolites

127. Ultra-high-throughput mapping of genetic design space

128. Little red dots as young supermassive black holes in dense ionized cocoons

129. N1-Methylpseudouridine directly modulates translation dynamics

130. The ubiquitin ligase KLHL6 drives resistance to CD8 T cell dysfunction

131. A nowhere-to-hide mechanism ensures complete piRNA-directed DNA methylation

132. Trapping of single atoms in metasurface optical tweezer arrays

133. Enriching African genome representation through the AGenDA project

134. Global subsidence of river deltas

135. Disease tolerance and infection pathogenesis age-related tradeoffs in mice

136. Ligand-specific activation trajectories dictate GPCR signalling in cells

137. 3D-printed low-voltage-driven ciliary hydrogel microactuators

138. A foundation model for continuous glucose monitoring data

139. Coherent nonlinear X-ray four-photon interaction with core-shell electrons

140. Training large language models on narrow tasks can lead to broad misalignment

141. Direct observation of the Migdal effect induced by neutron bombardment

142. Exciplex-enabled high-efficiency, fully stretchable OLEDs

143. Microbiota-induced T cell plasticity enables immune-mediated tumour control

144. Dominant contribution of Asgard archaea to eukaryogenesis

145. Mosaic lateral heterostructures in two-dimensional perovskite

146. Retraction Note: Antibodies against endogenous retroviruses promote lung cancer immunotherapy

147. AI can turbocharge scientists’ careers — but limit their scope

148. What the future holds for AI – from the people shaping it

149. Cancer might evade immune defences by stealing mitochondria

150. Take Nature’s poll: do you have a side hustle alongside your PhD studies?

151. Beneath acid skies

152. Predicting the fate of tropical forests under intensifying heat

153. Three tips for scientific writing: a guide for graduate students

154. Six steps to protect researchers’ digital security

155. Daily briefing: Same-sex sex is a normal part of some primates’ lives

156. The infection enigma: why some people die from typically harmless germs

157. Do their ears hang low? The genetics of dogs’ adorable floppy ears

158. How to improve vaccine uptake: a huge study offers clues

159. Should the Loch Ness Monster have a scientific name?

160. The academic community failed Wikipedia for 25 years — now it might fail us

161. AI can spark creativity — if we ask it how, not what, to think

162. How did birds evolve? The answer is wilder than anyone thought

163. AlphaFold can help African researchers to do cutting-edge structural biology

164. AI writing tools could lead scholars from low-income countries to erase their own voices

165. Don’t assume that women’s low retraction rates reflect male ‘boldness’

166. No world-changing discoveries without biodiversity

167. Daily briefing: The neural circuit that can make it hard to start a difficult task

168. Same-sex sexual behaviour can help primates to survive — and reproduce

169. US scientists push back as Trump eyes Greenland

170. Developing super-tortillas to address malnutrition in Latin America

171. ‘We’re humans — brilliant and a mess’: Wikipedia founder Jimmy Wales on trust and optimism

172. Student mental health is in crisis — here’s how to help

173. AIs are biased toward some Indian castes — how can researchers fix this?

174. Daily briefing: Fusion reactor pushes plasma past crucial limit

175. Fresh starts: how to thrive when you leave academia

176. Ancient ‘snowball’ Earth had frigidly briny seas

177. NASA won’t bring Mars samples back to Earth: this is the science that will be lost

178. Can’t get motivated? This brain circuit might explain why — and it can be turned off

179. We need to talk about salaries in science

180. Getting to the (square) root of stock-market swings

181. ‘Coming out as a transgender scientist made me the best teacher I’ve ever been’

182. This shapeshifting polymer was inspired by octopus skin

183. To infinity and beyond Earth’s pale blue dot: Books in brief

184. Daily briefing: Octopus-inspired synthetic ‘skin’ changes appearance on demand

185. Chinese nuclear fusion reactor pushes plasma past crucial limit: what happens next

186. Disappearing ‘planet’ reveals a solar system’s turbulent times

187. Chatbots in therapy: do AI models really have ''trauma''?

188. Huge Chinese cell atlas reveals surprising immune variation among peoples

189. Putting immune cells into ‘night mode’ reduces heart-attack damage

190. Will mpox go global again? Research shows it''s evolving in curious ways

191. Author Correction: Structural insights into BCDX2 complex function in homologous recombination

192. Daily briefing: How 400-year-old sharks keep their vision sharp

193. Oldest known poison arrows show Stone Age humans’ technological talents

194. Octopus-inspired ‘synthetic skin’ changes colour and texture on demand

195. Blood protein thwarts deadly fungal disease

196. A way to identify the biological basis of gene–trait associations

197. Exotic quasiparticles glimpsed in graphene

198. Chronic pain could be eased by uncoupling the sensory and emotional experiences

199. How viral RNAs escape a host mechanism that controls translation

200. Of all the quarries: Casablanca fossils reveal African ancestors of Homo sapiens

201. Ultra-low-density exoplanets observed around a young star

202. The complex role of nutrients in cancer spread

203. Oral 4′-fluorouridine rescues nonhuman primates from advanced Lassa fever

204. Stress controls heterochromatin inheritance via histone H3 ubiquitylation

205. Evidence accumulation from experience and observation in the cingulate cortex

206. ipRGC properties prevent light from shifting the SCN clock during daytime

207. Small persistent humid forest clearings drive tropical forest biomass losses

208. Albumin orchestrates a natural host defence mechanism against mucormycosis

209. A mechanical ratchet drives unilateral cytokinesis

210. Distinct neuronal populations in the human brain combine content and context

211. Mimicking opioid analgesia in cortical pain circuits

212. An ancient DNA perspective on the Russian conquest of Yakutia

213. Intratumoural vaccination via checkpoint degradation-coupled antigen presentation

214. Mitochondrial transfer from glia to neurons protects against peripheral neuropathy

215. Soft photonic skins with dynamic texture and colour control

216. Aharonov–Bohm interference in even-denominator fractional quantum Hall states

217. Towards fibre-like loss for photonic integration from violet to near-infrared

218. Nutrient requirements of organ-specific metastasis in breast cancer

219. Neuro-epithelial circuits promote sensory convergence and intestinal immunity

220. Pulse heating and slip enhance charging of phase-change thermal batteries

221. Insights into DNA repeat expansions among 900,000 biobank participants

222. Genetic switch between unicellularity and multicellularity in marine yeasts

223. Early hominins from Morocco basal to the Homo sapiens lineage

224. Soft biodegradable implants for long-distance and wide-angle sensing

225. Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit

226. Prefrontal neural geometry of learned cues guides motivated behaviours

227. Climate change shifts the North Pacific storm track polewards

228. High-voltage anode-free sodium–sulfur batteries

229. An expanded registry of candidate cis-regulatory elements

230. Plastic landmark anchoring in zebrafish compass neurons

231. RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity

232. Surface optimization governs the local design of physical networks

233. A young progenitor for the most common planetary systems in the Galaxy

234. A hidden diversity of ceratopsian dinosaurs in Late Cretaceous Europe

235. A framework for addressing racial and related inequities in conservation

236. A mysterious ancient fingerprint and a lemon-shaped planet — the stories you’ve missed

237. Systematic analyses of lipid mobilization by human lipid transfer proteins

238. Electrochemical defluorinative Matteson-type homologation

239. A troubleshooting guide to your flat-pack planet

240. Daily briefing: Animals without brains sleep too — hinting at why we sleep at all

241. ‘I rarely get outside’: scientists ditch fieldwork in the age of AI

242. Jellyfish sleep like humans — even though they don’t have brains

243. Artificial skin mimics the octopus’s art of disguise

244. Defossilize our chemical world

245. The poetic life and death of a glow-worm

246. Daily briefing: The human cells in our bodies that aren’t genetically ours

247. Why cancer can come back years later — and how to stop it

248. To improve resilience to climate change, track what endures

249. Retire ‘seminal’ from the scientific vocabulary

250. Help small-scale gold miners to transition away from mercury use

251. Rethink how we build AI to enable effective climate-change mitigation

252. Sunyaev–Zeldovich detection of hot intracluster gas at redshift 4.3

253. I see Mozambique’s baboons as windows into hominid evolution

254. Pandemic PhDs: graduates anxious, but optimistic, about the future

255. These women helped to shape quantum mechanics — it’s time to recognize them

256. Author Correction: Rewiring an olfactory circuit by altering cell-surface combinatorial code

257. Author Correction: Repulsions instruct synaptic partner matching in an olfactory circuit

258. Science in 2026: what to expect this year

259. Highly efficient LED device built by stacking layers of light-emitting perovskite

260. Sub-Saharan Africa has lost almost one-quarter of its pre-industrial biodiversity

261. How to reduce the environmental impact of wearable health-care devices

262. Economic inequality does not equate to poor well-being or mental health

263. Quantifying the global eco-footprint of wearable healthcare electronics

264. Random heteropolymers as enzyme mimics

265. A chiral fermionic valve driven by quantum geometry

266. Some of your cells are not genetically yours — what can they tell us about life and death?

267. Can boomerangs bounce?

268. Safe as houses

269. Put pressure on publishers to follow best practice — external regulation is the answer

270. Mummies give up their secrets — but not their mystery

271. Science in 2050: the future breakthroughs that will shape our world — and beyond

272. Audio long read: Will blockbuster obesity drugs revolutionize addiction treatment?

273. Probing pollutants: how I use penguin faeces to measure contaminants in Antarctica

274. Let 2026 be the year the world comes together for AI safety

275. Nine books to help shape your science career in 2026

276. Why academics should do more consulting — and how to make it work

277. The Nature Podcast highlights of 2025

278. Author Correction: Rolling back human pluripotent stem cells to an eight-cell embryo-like stage

279. Seeding opportunities for Black atmospheric scientists

280. Non-equilibrium snapshots of ligand efficacy at the μ-opioid receptor

281. NAC controls nascent chain fate through tunnel sensing and chaperone action

282. Daily briefing: Explore 2025 with Leif Penguinson

283. AI and quantum science take centre stage under Trump — but with little new proposed funding

284. ‘A serious problem’: peer reviews created using AI can avoid detection

285. Nature''s News & Views roundup of 2025

286. Oddly cool super-hot planet has an atmosphere it shouldn’t

287. Are we living in a parallel universe? The strange physics of Stranger Things

288. Author Correction: Cryo-EM structure of a natural RNA nanocage

289. Point of no returns: researchers are crossing a threshold in the fight for funding

290. Publisher Correction: Covalent targeted radioligands potentiate radionuclide therapy

291. US–Africa bilateral health deals won’t help against diseases that ignore borders

292. Dogma-defying signalling through G proteins could lead to better pain relief

293. Science in 2026: the events to watch for in the coming year

294. Hot spot: plants use infrared signals to say they’re ready to reproduce

295. Living water and whispering rocks: Books in brief

296. Trump team plans to break up ‘global mothership’ of climate science

297. Genes don’t explain what made humans different

298. How the Romans built their empire of concrete

299. Take the News & Views end-of-year quiz: vampire fungus, migratory moths and a 160-year-old mystery

300. Restoring youth to old immune cells: mRNA therapy turns back the clock.