1. Science in 2026: what to expect this year

2. Highly efficient LED device built by stacking layers of light-emitting perovskite

3. Sub-Saharan Africa has lost almost one-quarter of its pre-industrial biodiversity

4. How to reduce the environmental impact of wearable health-care devices

5. Economic inequality does not equate to poor well-being or mental health

6. Quantifying the global eco-footprint of wearable healthcare electronics

7. Random heteropolymers as enzyme mimics

8. A chiral fermionic valve driven by quantum geometry

9. Some of your cells are not genetically yours — what can they tell us about life and death?

10. Can boomerangs bounce?

11. Safe as houses

12. Put pressure on publishers to follow best practice — external regulation is the answer

13. Mummies give up their secrets — but not their mystery

14. Science in 2050: the future breakthroughs that will shape our world — and beyond

15. Audio long read: Will blockbuster obesity drugs revolutionize addiction treatment?

16. Probing pollutants: how I use penguin faeces to measure contaminants in Antarctica

17. Let 2026 be the year the world comes together for AI safety

18. Nine books to help shape your science career in 2026

19. Why academics should do more consulting — and how to make it work

20. The Nature Podcast highlights of 2025

21. Author Correction: Rolling back human pluripotent stem cells to an eight-cell embryo-like stage

22. Seeding opportunities for Black atmospheric scientists

23. Non-equilibrium snapshots of ligand efficacy at the μ-opioid receptor

24. NAC controls nascent chain fate through tunnel sensing and chaperone action

25. Daily briefing: Explore 2025 with Leif Penguinson

26. AI and quantum science take centre stage under Trump — but with little new proposed funding

27. ‘A serious problem’: peer reviews created using AI can avoid detection

28. Nature''s News & Views roundup of 2025

29. Oddly cool super-hot planet has an atmosphere it shouldn’t

30. Are we living in a parallel universe? The strange physics of Stranger Things

31. Author Correction: Cryo-EM structure of a natural RNA nanocage

32. Point of no returns: researchers are crossing a threshold in the fight for funding

33. Publisher Correction: Covalent targeted radioligands potentiate radionuclide therapy

34. US–Africa bilateral health deals won’t help against diseases that ignore borders

35. Dogma-defying signalling through G proteins could lead to better pain relief

36. Science in 2026: the events to watch for in the coming year

37. Hot spot: plants use infrared signals to say they’re ready to reproduce

38. Living water and whispering rocks: Books in brief

39. Trump team plans to break up ‘global mothership’ of climate science

40. Genes don’t explain what made humans different

41. How the Romans built their empire of concrete

42. Take the News & Views end-of-year quiz: vampire fungus, migratory moths and a 160-year-old mystery

43. Restoring youth to old immune cells: mRNA therapy turns back the clock.

44. Systematic maps reveal how human chromosomes are organized

45. A modular quantum processor made using phosphorus atoms in silicon

46. The Nature Podcast festive spectacular 2025

47. How common is Alzheimer’s? Blood-test study holds surprises

48. Mechanism for water formation on rocky exoplanets demonstrated in the lab

49. The hidden cost of video-call glitches

50. 3D nanolithography with metalens arrays and spatially adaptive illumination

51. Laser spectroscopy and CP-violation sensitivity of actinium monofluoride

52. Lesion-remote astrocytes govern microglia-mediated white matter repair

53. Spatiotemporal cellular map of the developing human reproductive tract

54. Human assembloids recapitulate periportal liver tissue in vitro

55. Titan’s strong tidal dissipation precludes a subsurface ocean

56. Prevalence of Alzheimer’s disease pathology in the community

57. Visualizing interaction-driven restructuring of quantum Hall edge states

58. The global hydrogen budget

59. An 11-qubit atom processor in silicon

60. Astrocyte CCN1 stabilizes neural circuits in the adult brain

61. Palaeometabolomes yield biological and ecological profiles at early human sites

62. An integrated view of the structure and function of the human 4D nucleome

63. Programmable 200 GOPS Hopfield-inspired photonic Ising machine

64. GTP release-selective agonists prolong opioid analgesic efficacy

65. Gene-specific selective sweeps are pervasive across human gut microbiomes

66. Transient hepatic reconstitution of trophic factors enhances aged immunity

67. Mazdutide versus placebo in Chinese adults with type 2 diabetes

68. Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes

69. MIT fusion-lab head shot dead: a horror ''impossible to believe''

70. Immunological sin: how a person’s earliest flu infections dictate life-long immunity

71. Annual flu vaccines are far from ideal — this is why

72. A universal flu vaccine has proved challenging — could it finally be possible?

73. The quest to hatch a bird-flu vaccine

74. Could tracking animals’ health help to avert the next pandemic?

75. Flu’s link to cardiovascular disease shows why vaccination is essential

76. Virology’s most wanted: the influenza virus

77. Seven feel-good science stories to restore your faith in 2025

78. Beauty is in the eye of the beholder

79. Stopping the next flu pandemic

80. Is bird flu the next pandemic? The science so far

81. Author Correction: Neuroimmune cardiovascular interfaces control atherosclerosis

82. I’ve earned my PhD — what now?

83. Scientists skip key US meetings — and seize on smaller alternatives

84. Safety regulations for cloning and a compass that finds true north

85. How my institution strengthened research despite chronic underfunding

86. Science’s role in my Great British Sewing Bee success

87. AI is transforming the economy — understanding its impact requires both data and imagination

88. More than half of researchers now use AI for peer review — often against guidance

89. NSF softens grant-review rules to cope with backlog

90. Tracing pollution in the lives of Arctic seabirds

91. How fasting boosts breast cancer therapy

92. The best science images of 2025 — Nature’s picks

93. Giving a voice to animals: Laos’s national herpetologist on her day-to-day

94. Grant cuts, arrests, lay-offs: Trump made 2025 a tumultuous year for science

95. Despite all the negatives, 2025 showcased the power, resilience and universality of science

96. Author Correction: Unravelling cysteine-deficiency-associated rapid weight loss

97. Science sleuths raise concerns about scores of bioengineering papers

98. Revised estimates of CO2 sources and sinks improve global carbon accounting

99. China leads research in 90% of crucial technologies — a dramatic shift this century

100. Author Correction: Distinct fibroblast subsets drive inflammation and damage in arthritis

101. Author Correction: Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

102. In praise of inefficiency, failure and friendship: ten galvanizing reads for this festive season

103. Giant 3D map shows almost every building in the world

104. Quantum computing ‘KPIs’ could distinguish true breakthroughs from spurious claims

105. Solar cells that combine multiple perovskite layers surpass 30% efficiency

106. The gift that shaped my career in science

107. Asteroids, antibiotics and ants: a year of remarkable science

108. Author Correction: Conservation and alteration of mammalian striatal interneurons

109. Australia’s world-first social media ban is a ‘natural experiment’ for scientists

110. This AI model ‘studied’ physics — and learnt to forecast extreme weather

111. Huge genetic study reveals hidden links between psychiatric conditions

112. Oldest known evidence of the controlled ignition of fire

113. Shared genetic risk in psychiatric disorders

114. The brain’s speech centre responds to universal and specific features of language

115. Genetically engineered mosquitoes block development of circulating malaria strains

116. Nuclear clocks could use electrical signals to keep time

117. A simple slipknot for precise force control

118. SOS: RNA-processing mechanism rescues genes from invasive DNA

119. A giant catalogue of microscopic species across Denmark

120. Gut micro-organisms associated with health, nutrition and dietary interventions

121. Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency

122. Causal modelling of gene effects from regulators to programs to traits

123. Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity

124. Laser-based conversion electron Mössbauer spectroscopy of 229ThO2

125. Protected area management has significant spillover effects on vegetation

126. Somatic evolution following cancer treatment in normal tissue

127. Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma

128. An RNA splicing system that excises DNA transposons from animal mRNAs

129. Mapping the genetic landscape across 14 psychiatric disorders

130. Neutrophils preserve energy storage in sympathetically activated adipocytes

131. A direct role for a mitochondrial targeting sequence in signalling stress

132. Hot droughts in the Amazon provide a window to a future hypertropical climate

133. Observation of deuteron and antideuteron formation from resonance-decay nucleons

134. Earliest evidence of making fire

135. Sterilization and contraception increase lifespan across vertebrates

136. Cross-regulation of [2Fe–2S] cluster synthesis by ferredoxin-2 and frataxin

137. Human gut M cells resemble dendritic cells and present gluten antigen

138. Erythropoietin receptor on cDC1s dictates immune tolerance

139. Gene-drive-capable mosquitoes suppress patient-derived malaria in Tanzania

140. Quantifying grain boundary deformation mechanisms in small-grained metals

141. The influence of short-lived halogens on atmospheric chemistry and climate

142. Fasting boosts breast cancer therapy efficacy via glucocorticoid activation

143. Neanderthals mastered fire — 400,000 years ago

144. Four young universities share their strategies for success

145. What would an AI university look like and how might it change education?

146. Will young universities set the pace in the age of AI?

147. Early detection could improve pancreatic cancer’s poor survival rates

148. Therapeutic vaccines can challenge pancreatic cancer before it takes hold

149. The pancreatic cancer models helping to drive innovation in the field

150. A breathalyser-style test for detecting pancreatic cancer

151. Six highlights from pancreatic cancer research

152. Pancreatic cancer is evasive. Is the nervous system the reason why?

153. Exposing a silent cancer

154. Glimmers of hope for a deadly disease

155. But only just

156. China is leading the world on AI governance: other countries must engage

157. Is your brain tired? Researchers are discovering the roots of mental fatigue

158. A poetic ode to eddies and an earwig’s brush with death

159. What will be the first AI-designed drug? These disease-fighting antibodies are top contenders

160. What we eat is making us obese and sick — but science shows solutions are within reach

161. Food will be more affordable — if we double funds for agriculture research now

162. Argentina must finish building the CART radio telescope

163. Drug woes won’t be tamed by US price regulations

164. Better models are needed to gauge the ecological impacts of reservoirs

165. Don’t overlook the value of co-supervision in PhD training

166. The first global pandemic treaty — and the woman who made it happen

167. This scientist found a new trick of the immune system by digging through cellular rubbish

168. This science sleuth revealed a retraction crisis at Indian universities

169. 9,000 metres under the sea: this researcher found the deepest animal ecosystems on Earth

170. The visionary physicist who gave us a new way to view the cosmos

171. The Chinese finance whizz whose DeepSeek AI model stunned the world

172. The top US health director who stood up for science — and was fired

173. ‘Giant step forward’ for Huntington’s — the scientist behind the first gene therapy

174. The baby whose life was saved by the first personalized CRISPR therapy

175. This scientist is breeding billions of mosquitoes to fight disease in Brazil

176. Nature’s 10: Ten people who shaped science in 2025

177. Five years of COVID vaccines: how a breakthrough created a public-heath crisis

178. Home-field advantage: how local research leads to new discoveries

179. How to get science back into policymaking

180. Long-COVID research just got a big funding boost: will it find new treatments?

181. Five important financial moves for PhD students

182. Publisher Correction: CRISPR activation for SCN2A-related neurodevelopmental disorders

183. How the Royal Institution made science a seasonal spectacle

184. The Indian Ocean disaster is a climate tragedy — and needs more attention

185. AI is saving time and money in research — but at what cost?

186. These are a few of my favourite sounds: Books in brief

187. Fate of hepatitis B vaccine for US babies hangs in the balance

188. DeepSeek’s self-correcting AI model aces tough maths proofs

189. AI chatbots can persuade voters to change their minds

190. AI chatbots can sway voters with remarkable ease — is it time to worry?

191. China’s scientific clout is growing as US influence wanes: the data show how

192. Persuading voters using human–artificial intelligence dialogues

193. Aluminium is crucial to vaccines — and safe. Why are US advisers debating it?

194. Author Correction: Activity of caspase-8 determines plasticity between cell death pathways

195. Experimental vaccine prevents deadly allergic reactions in mice

196. Satellite swarms set to photobomb more than 95% of some telescopes’ images

197. Still no sign of hypothetical sterile-neutrino particle

198. Quarks in ‘exotic’ quartets prefer to stick together

199. Even in space, telescopes can’t escape photobombers

200. Order in which cancer-driving mutations occur affects the chance of tumour development

201. Primate embryo model leaps across developmental boundaries

202. A glasses-free 3D display uses AI to direct images straight to the viewer’s eyes

203. Decay of driver mutations shapes the landscape of intestinal transformation

204. Architecture of the neutrophil compartment

205. Homo sapiens-specific evolution unveiled by ancient southern African genomes

206. Viral RNA blocks circularization to evade host codon usage control

207. Search for light sterile neutrinos with two neutrino beams at MicroBooNE

208. Video-call glitches trigger uncanniness and harm consequential life outcomes

209. Built environment disparities are amplified during extreme weather recovery

210. Computational enzyme design by catalytic motif scaffolding

211. Satellite megaconstellations will threaten space-based astronomy

212. Determination of the spin and parity of all-charm tetraquarks

213. The Microflora Danica atlas of Danish environmental microbiomes

214. TSC tunes progenitor balance and upper-layer neuron generation in neocortex

215. Dated gene duplications elucidate the evolutionary assembly of eukaryotes

216. Modelling late gastrulation in stem cell-derived monkey embryo models

217. Whole-genome landscapes of 1,364 breast cancers

218. Sterile-neutrino search based on 259 days of KATRIN data

219. A place-based assessment of biodiversity intactness in sub-Saharan Africa

220. Computational design of metallohydrolases

221. Photobombing satellites could ruin the night sky for space telescopes

222. Building mentally healthy cities with neuroscience

223. How cities can keep their cool

224. Cities aren’t built for women — it’s time to change that

225. Wooden skyscrapers point the way to more sustainable cities

226. Geothermal networks let cities warm and cool as one

227. Cities are embracing nature for flood defence

228. Data drive city transportation forwards

229. Darleane C. Hoffman obituary: chemist who expanded the periodic table

230. Growing cities face mounting challenges

231. A bothy among the stars

232. Author Correction: Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

233. China accounts for more than half of leading output in the applied sciences

234. ‘Anyone hired a student before?’ How a group of novice lab leaders are supporting each other

235. Author Correction: Seismic detection of a 600-km solid inner core in Mars

236. AI reviewers are here — we are not ready

237. Retraction Note: The economic commitment of climate change

238. The ‘silent’ brain cells that shape our behaviour, memory and health

239. This is the world’s largest spider web — November’s best science images

240. Practical alternative to explosive reaction will improve lab safety

241. Bulk superconductivity up to 96 K in pressurized nickelate single crystals

242. Don’t downplay problems of bullying and harassment in academia

243. Towns lag behind the switch to standard time

244. Author Correction: The first-principles phase diagram of monolayer nanoconfined water

245. Great science happens in great teams — research assessments must try to capture that

246. ‘Fire amoeba’ survives in hotter conditions than any other complex cell

247. Author Correction: Video‐rate tunable colour electronic paper with human resolution

248. Why universities need to radically rethink exams in the age of AI

249. Alternatives to animal research are not inherently more ethical

250. Drinking water is at risk during warfare — better protections are needed

251. Ease the EU postdoc job market with better routes to innovation

252. Memes reveal threats to graduate-student mental health

253. Will blockbuster obesity drugs revolutionize addiction treatment?

254. Antibodies and T cells join forces for sustained HIV remission

255. Correlates of HIV-1 control after combination immunotherapy

256. Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation

257. CD8 T cell stemness precedes post-intervention control of HIV viremia

258. Climbing through the silver mine: my work as a geologist

259. Spineless creatures, possibly the world’s oldest beer receipt and more: 2025’s best Books in brief

260. Nature at its weirdest: what metamorphosis reveals about science and ourselves

261. David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS

262. China wants to lead the world on AI regulation — will the plan work?

263. Cooking up a storm of air pollution

264. The mystery of emerald green — cracked

265. AI finds signs of life in ancient rocks

266. Editorial Expression of Concern: Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

267. Audio long read: Faulty mitochondria cause deadly diseases — fixing them is about to get a lot easier

268. Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

269. Author Correction: Evidence for improved DNA repair in the long-lived bowhead whale

270. Laser cooling traps more antimatter atoms than ever before

271. A structured system: the secrets of Germany’s scientific reputation

272. Large language models are biased — local initiatives are fighting for change

273. Author Correction: Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants

274. Major AI conference flooded with peer-reviews written fully by AI

275. Author Correction: Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

276. Author Correction: Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver

277. AlphaFold is five years old — these charts show how it revolutionized science

278. Land-use changes threaten the safety net for birds

279. Shape-shifting electrodes tune optical-frequency converter

280. Ancient DNA offers clues about mysterious prehistoric settlement in China

281. Weighing up the wild-meat harvest in Amazonia

282. Is there lightning on Mars?

283. Mystery owner of African hominin foot identified

284. Double whammy: drugs that inhibit kinase enzymes also speed up their disposal

285. A distinctive human genetic lineage persisted in central Argentina for 8,500 years

286. Yarns and fabrics that bend or stiffen under magnetic fields

287. Digging into the mechanisms that underlie soil production

288. Long-read metagenomics reveals phage dynamics in the human gut microbiome

289. Operating two exchange-only qubits in parallel

290. Healthy forests safeguard traditional wild meat food systems in Amazonia

291. Entanglement-enhanced nanoscale single-spin sensing

292. Progressive coevolution of the yeast centromere and kinetochore

293. Detection of triboelectric discharges during dust events on Mars

294. Glasses-free 3D display with ultrawide viewing range using deep learning

295. Land-use change undermines the stability of avian functional diversity

296. No meta-analytical effect of economic inequality on well-being or mental health

297. Evolution of taste processing shifts dietary preference

298. New finds shed light on diet and locomotion in Australopithecus deyiremeda

299. Ancient DNA from Shimao city records kinship practices in Neolithic China

300. Inhibitors supercharge kinase turnover through native proteolytic circuits