1. Hundreds more NSF grants terminated after agency director resigns

2. My ‘woke DEI’ grant has been flagged for scrutiny. Where do I go from here?

3. This is not the new colour that scientists have created

4. Huge reproducibility project fails to validate dozens of biomedical studies

5. Audio long read: Do smartphones and social media really harm teens’ mental health?

6. ‘Tatooine’-like planet orbits two stars ― but at a weird angle

7. Daily briefing: Ancient Phoenicians spread their culture — but not their DNA

8. Major European institutes join race to save US science data

9. How Trump’s attack on universities is putting research in peril

10. How Democrats and Republicans cite science: study reveals stark differences

11. Baffling chronic pain eases after doses of gut microbes

12. Editorial Expression of Concern: A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

13. Editorial Expression of Concern: Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

14. Science sleuths flag hundreds of papers that use AI without disclosing it

15. Parkinson’s gut-microbiota links raise treatment possibilities

16. Eugenics is on the rise again: human geneticists must take a stand

17. Daily briefing: Sea-turtle conservation is working

18. Why US police shootings are so deadly ― and why some police forces do better

19. A front-line antiviral drug disappoints against worrisome monkeypox strain

20. The text of dozens of burnt Herculaneum scrolls could soon be revealed

21. Century-old genetics mystery of Mendel’s peas finally solved

22. A brand-new colour created by lasers, a pig-liver transplant trial gets the green light, and a nugget-sized chunk of lab-grown meat

23. Quantum communication across a 250-kilometre optical-fibre network

24. Blood cancer driven by ‘one hit’ mutation event undergoes rapid growth

25. mRNA technology helps reinvigorate the hunt for cancer vaccines

26. Memories of a cold place trigger bodily responses to warm up

27. Heart-attack outcomes are worse in the morning when activity of protein duo dips

28. Cancer vaccine momentum builds, but US funding cuts raise concerns

29. A protein tunnel that shuttles lipids around the cell

30. Shapeshifting origami material shrinks when twisted

31. Psychedelics reduce fear by targeting immune cells that modulate brain cells

32. Answers to a 160-year-old riddle about the genetics of Mendel’s pea traits

33. Tracking the evolution and persistence of antibiotic resistance in the human gut

34. Structural basis of lipid transfer by a bridge-like lipid-transfer protein

35. Brief antibiotic use drives human gut bacteria towards low-cost resistance

36. Punic people were genetically diverse with almost no Levantine ancestors

37. Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer

38. A distributed coding logic for thermosensation and inflammatory pain

39. Human de novo mutation rates from a four-generation pedigree reference

40. Genomic and genetic insights into Mendel’s pea genes

41. Targeting PIKfyve-driven lipid metabolism in pancreatic cancer

42. Melt focusing along lithosphere–asthenosphere boundary below Axial volcano

43. Modular chiral origami metamaterials

44. Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1

45. Quantum twisting microscopy of phonons in twisted bilayer graphene

46. BMAL1–HIF2A heterodimer modulates circadian variations of myocardial injury

47. Long-distance coherent quantum communications in deployed telecom networks

48. Effects of glacial forcing on lithospheric motion and ridge spreading

49. Atomic lift-off of epitaxial membranes for cooling-free infrared detection

50. Cold memories control whole-body thermoregulatory responses

51. Deciphering disordered regions controlling mRNA decay in high-throughput

52. Carbon majors and the scientific case for climate liability

53. Superconducting gap of H3S measured by tunnelling spectroscopy

54. Psychedelic control of neuroimmune interactions governing fear

55. Ancient DNA poses puzzle of why Phoenicians spread culture but not their genes

56. An origami design for metamaterial robots

57. Geographic and age variations in mutational processes in colorectal cancer

58. Whole-body physics simulation of fruit fly locomotion

59. Daily briefing: Potato pangenome reveals the complex genetics of the humble spud

60. How AI is helping to boost cancer screening

61. Four rising stars at the forefront of cancer research

62. Clinical trials by the numbers

63. China overtakes the United States in cancer research output

64. Wild strawberries on Mars

65. Publisher Correction: Oncolytic virus VG161 in refractory hepatocellular carcinoma

66. How we’re battling Trump’s science cuts across small-town America

67. Scientific naming conventions should keep in step with contemporary science

68. Author Correction: Global influence of soil texture on ecosystem water limitation

69. Three ways to cool Earth by pulling carbon from the sky

70. Custom CRISPR—Cas9 PAM variants via scalable engineering and machine learning

71. Substrate recognition and cleavage mechanism of the monkeypox protease, Core protease

72. Stereoretentive radical cross-coupling

73. Kidney disease is a worldwide killer. Treat it that way

74. Top of the crops: rice scientists seek to meet global food demands

75. Arctic researchers need to find ways to keep working together

76. Author Correction: Structure of the human dopamine transporter in complex with cocaine

77. Which programming language should I use? A guide for early-career researchers

78. Exclusive: a Nature analysis signals the beginnings of a US science brain drain

79. ‘Dark matter’, ''Big Bang'' and ‘spin’: how physics terms can confuse researchers

80. Daily briefing: The biggest single piece of meat ever grown in the lab

81. Sexual harassment thrives in silence, even in gender-equality hotspots

82. The global assault on universities is an attack on democracy

83. Trade tariffs could worsen deforestation in South America

84. Defend scientific integrity and academic freedom

85. Europe must become a research epicentre as US system gets undermined

86. How India rewrote the rules of space travel when it launched its first satellite

87. Brand-new colour created by tricking human eyes with laser

88. Exclusive: Trump team freezes new NSF awards — and could soon axe hundreds of grants

89. Signs of life on a distant planet? Not so fast, say these astronomers

90. Martian rock hints at ancient dense atmosphere

91. Microplastic pollution found in insect casing from 1971

92. Invasion of the ‘journal snatchers’: the firms that buy science publications and turn them rogue

93. Daily briefing: The first colossal squid caught on camera in its natural habitat

94. ‘Totally broken’: how Trump 2.0 has paralysed work at US science agencies

95. 25 million deaths: what could happen if the US ends global health funding

96. Whole-genome sequencing susses out rare diseases

97. Sowing solutions: my quest to save Kenya’s maize from a devastating invader

98. Author Correction: Continued Atlantic overturning circulation even under climate extremes

99. Why politicians manipulate statistics — and what to do about it

100. The lunatic is on the grass: Books in brief

101. Winner, winner, lab-made dinner! Team grows nugget-sized chicken chunk

102. ‘Big leap’ for Parkinson’s treatment: symptoms improve in stem-cells trials

103. SWOT satellite provides a finer view of climate-driving ocean dynamics

104. Highly sensitive method captures rare RNAs in blood to search for disease

105. Unlocking the diversity of wild and domesticated rice

106. Japan’s big bet on stem-cell therapies might soon pay off with breakthrough therapies

107. Clinical trials test the safety of stem-cell therapy for Parkinson’s disease

108. Don’t rush promising stem-cell therapies

109. Age-related blood condition counteracted with a common diabetes drug

110. The first observation of ‘plastic ice’ reveals unusual behaviour of water molecules

111. Negative thermal expansion and oxygen-redox electrochemistry

112. Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease

113. Low overlap of transcription factor DNA binding and regulatory targets

114. Wide-swath satellite altimetry unveils global submesoscale ocean dynamics

115. Deep Visual Proteomics maps proteotoxicity in a genetic liver disease

116. Generation of human adult hepatocyte organoids with metabolic functions

117. Towards multimodal foundation models in molecular cell biology

118. Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines

119. Histone H1 deamidation facilitates chromatin relaxation for DNA repair

120. Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation

121. Antiferromagnetic quantum anomalous Hall effect under spin flips and flops

122. The growing memristor industry

123. Chromosome end protection by RAP1-mediated inhibition of DNA-PK

124. Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease

125. Driven bright solitons on a mid-infrared laser chip

126. A sharp volatile-rich cap to the Yellowstone magmatic system

127. Subnanosecond flash memory enabled by 2D-enhanced hot-carrier injection

128. Observation of the axion quasiparticle in 2D MnBi2Te4

129. An ultrasensitive method for detection of cell-free RNA

130. Structure of the ATP-driven methyl-coenzyme M reductase activation complex

131. A pangenome reference of wild and cultivated rice

132. Multi-zonal liver organoids from human pluripotent stem cells

133. Electric-field-induced domain walls in wurtzite ferroelectrics

134. Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs

135. The phased pan-genome of tetraploid European potato

136. Bovine H5N1 binds poorly to human-type sialic acid receptors

137. Natively expressed AcrIII-1 does not function as an anti-CRISPR protein

138. Receptor-binding specificity of a bovine influenza A virus

139. What a trove of potato genomes reveals about the humble spud

140. A. J. Eisfeld et al. reply

141. Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

142. Reply to: Natively expressed AcrIII-1 does not function as an anti-CRISPR protein

143. Spain adapts to new reality as climate crisis hits home

144. Meet the researchers pioneering Spanish climate solutions

145. Healthy soil is the hidden ingredient — here’s how I’m fighting to save it

146. How a hydrogen lab is helping to power Spain’s green-energy shift

147. The future of Alzheimer’s treatment

148. Do infections have a role in Alzheimer’s disease?

149. Why women experience Alzheimer’s disease differently from men

150. Alzheimer’s disease: highlights from research

151. The unusual genetic inheritance that could change Alzheimer’s treatment

152. Faster, cheaper, better: the rise of blood tests for Alzheimer’s

153. Reframe perspectives on Alzheimer’s disease

154. Within dead branches

155. Don’t believe the hype — quantum tech can’t yet solve real-world problems

156. Science on our sleeves: the research that inspires our tattoos

157. First global pandemic treaty agreed — without the US

158. Roses are red — but their ancestors were yellow

159. Daily briefing: Leaked documents reveal the next science funding on Trump’s chopping block

160. You’re only human: a six-step strategy to surviving your PhD

161. Print, melt, repeat: 3D-printing formula yields sturdy objects time after time

162. Richard Fortey obituary: palaeontologist, author and TV presenter who traced continents through fossils

163. High time to tackle drug-resistant fungal infections

164. Scientists must regain trust

165. Lung signals drive cancer-associated blood clots

166. Twenty years of genome-wide association studies

167. Early air-pollution activists fight against city smoke

168. Pig livers for people: US regulator greenlights first safety trial

169. Should I return to my home country after my PhD abroad?

170. The fight to keep big tech in check: digital researchers are in ‘David and Goliath’ battle

171. Africa CDC must become financially independent

172. Discussions of technologies’ societal impacts are still too limited

173. Ensuring that conferences are inclusive requires diverse organizers

174. Daily briefing: Five lawsuits have been filed in response to NIH cuts — what now?

175. Exclusive: the most-cited papers of the twenty-first century

176. These are the most-cited research papers of all time

177. Science’s golden oldies: the decades-old research papers still heavily cited today

178. Five key climate and space projects on Trump’s chopping block

179. AI-boosted cameras help blind people to navigate

180. Prdm16-dependent antigen-presenting cells induce tolerance to gut antigens

181. Dear US researchers: break the outrage addiction. I survived the besieging of science. So can you

182. Radical approach to shrink particle colliders gains momentum

183. Understanding bones from the remote wilderness of Wyoming

184. How a ‘boring administrative task’ transformed my PhD career

185. How the United States became a science superpower — and how quickly it could crumble

186. Five years on: how Brexit changed three scientists’ careers

187. Daily briefing: Mysterious Taiwan fossil is Denisovan

188. ‘I’m touching space’: the fascinating insights meteorites can bring us

189. The dangerous fantasies driving the quest for super-intelligent AI

190. NIH cuts triggered a host of lawsuits: Nature’s guide to what’s next

191. Liquids in a glass recover a graceful shape even after being shaken

192. Mystery of medieval manuscripts revealed by ancient DNA

193. Author Correction: Sulfide-rich continental roots at cratonic margins formed by carbonated melts

194. Daily briefing: Dogs have a serious environmental impact — but owners can mitigate it

195. How Trump 2.0 is slashing NIH-backed research — in charts

196. Mysterious human fossil found in Taiwan was a Denisovan

197. Physicists narrow down neutrino’s mysterious mass

198. Allergic reactions flare in the gut after cuts to the skin, mouse research shows

199. ‘Mind blowing’: quantum computer untangles the mathematics of knots

200. Top quarks spotted at mega-detector could reveal clues to early Universe

201. Can peer-reviewed podcasts fast-track science?

202. Daily briefing: Tonka bean trees survive lightning strikes that kill their competitors

203. Data centres will use twice as much energy by 2030 — driven by AI

204. Brain cells given an ‘invisibility cloak’ fix Parkinson’s symptoms in rats

205. These 4,200-year-old cymbals show music’s far-reaching power

206. Will AI improve your life? Here’s what 4,000 researchers think

207. Biggest brain map ever details huge number of neurons and their activity

208. DNA-guided transcription factor interactions extend human gene regulatory code

209. What makes us human? Milestone ape genomes promise clues

210. Skin wound healing measured remotely through molecular flux

211. Why it’s time the United Nations is led by a woman

212. Jurassic fossil reveals the origin of parasitic thorny-headed worms

213. A mental-health crisis plagues PhDs — these evidence-led initiatives offer help

214. Chronic stress drives depression by disrupting cellular housekeeping

215. A map of neural signals and circuits traces the logic of brain computation

216. Complete ape genomes offer a close-up view of human evolution

217. A wetter ancient Arabia could have enabled easier intercontinental species dispersal

218. Photonic chips provide a processing boost for AI

219. Docking stations in porous crystals unlock elusive molecular structures

220. Cancer vulnerabilities exposed by finding interactions among DNA repair factors

221. Airborne microplastics enter plant leaves and end up in our food

222. Hunter-gatherers journeyed by sea to Malta

223. Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia

224. Functional connectomics reveals general wiring rule in mouse visual cortex

225. Spatial multi-omics reveals cell-type-specific nuclear compartments

226. An integrated large-scale photonic accelerator with ultralow latency

227. Towards conversational diagnostic artificial intelligence

228. Supramolecular docking structure determination of alkyl-bearing molecules

229. Multimodal cell maps as a foundation for structural and functional genomics

230. Intersectional analysis for science and technology

231. Recurrent humid phases in Arabia over the past 8 million years

232. Universal photonic artificial intelligence acceleration

233. Stress dynamically modulates neuronal autophagy to gate depression onset

234. Evidence of star cluster migration and merger in dwarf galaxies

235. A Jurassic acanthocephalan illuminates the origin of thorny-headed worms

236. Functional connectomics spanning multiple areas of mouse visual cortex

237. Translational genomics of osteoarthritis in 1,962,069 individuals

238. Small molecules restore mutant mitochondrial DNA polymerase activity

239. Water abundance in the lunar farside mantle

240. Inhibitory specificity from a connectomic census of mouse visual cortex

241. Transforming ceria into 2D clusters enhances catalytic activity

242. Goal-specific hippocampal inhibition gates learning

243. Complete sequencing of ape genomes

244. NEURD offers automated proofreading and feature extraction for connectomics

245. Hunter-gatherer sea voyages extended to remotest Mediterranean islands

246. Reprogramming site-specific retrotransposon activity to new DNA sites

247. A non-contact wearable device for monitoring epidermal molecular flux

248. Giant electrocaloric effect in high-polar-entropy perovskite oxides

249. Seismic imaging of a basaltic Lesser Antilles slab from ancient tectonics

250. Comprehensive interrogation of synthetic lethality in the DNA damage response

251. Perisomatic ultrastructure efficiently classifies cells in mouse cortex

252. Human assembloid model of the ascending neural sensory pathway

253. Phenotypic complexities of rare heterozygous neurexin-1 deletions

254. Leaf absorption contributes to accumulation of microplastics in plants

255. Foundation model of neural activity predicts response to new stimulus types

256. Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM

257. Active energy compression of a laser-plasma electron beam

258. Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

259. Ultra-broadband optical amplification using nonlinear integrated waveguides

260. Connectomics of predicted Sst transcriptomic types in mouse visual cortex

261. Towards accurate differential diagnosis with large language models

262. Long-awaited ape genomes give new insights into their evolution — and ours

263. The great brain clearance and dementia debate

264. Losing weight through better sleep

265. Sleep is essential — researchers are trying to work out why

266. The life aquatic: this board game lets you dip into marine ecology

267. Research round-up: sleep

268. New treatments to put insomnia to bed

269. The infuriating, expensive road to a good night’s sleep

270. Unlocking the secrets of sleep

271. Relics

272. How do I explain the publication gap I ended up with after a hostile manager?

273. Microbial warfare brought us CRISPR. What big breakthroughs could be next?

274. NSF slashes prestigious PhD fellowship awards by half

275. Tiger turnaround as populations grow in India

276. Does US science have a future in Antarctica? Trump cuts threaten to cancel fieldwork and more

277. A Nd@C82-polymer interface for efficient and stable perovskite solar cells

278. Asilomar conference took courage and foresight — today, inclusivity would also be crucial

279. An animal source of mpox emerges — and it’s a squirrel

280. Cannabis studies were informing fundamental neuroscience in the 1970s

281. ‘Now is not the time for despair’ — how scientists can take a stand against political interference

282. Cells are swapping their mitochondria. What does this mean for our health?

283. Norway set to scrap mandatory language training for foreign postdocs and PhD students

284. Science’s big problem is a loss of influence, not a loss of trust

285. Countries must consider their global footprint when using natural resources

286. Europe needs to step up on epidemic preparedness

287. Europe must grasp chance to become a scientific powerhouse

288. The US is against the world on sustainable development

289. Daily briefing: The physicist behind baseball’s new ‘torpedo’ bat

290. 154 million lives and counting: 5 charts reveal the power of vaccines

291. Creating an ‘all comers’ research group in quantitative history

292. Long COVID activists fought Trump team’s research cuts and won ― for now

293. Daily briefing: This brain structure filters which thoughts we become aware of

294. Studying seabirds with a cactus as a research assistant

295. Where do proteins go in cells? Next-generation methods map the molecules’ hidden lives

296. AI for research: the ultimate guide to choosing the right tool

297. From Hippocrates to COVID-19: the scientific fight to prove diseases can be airborne

298. AI race in 2025 is tighter than ever before

299. Why more AI researchers should collaborate with governments

300. Author Correction: Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome