1. Open-source protein structure AI aims to match AlphaFold

2. Glowing sperm helps to reveal secrets of mosquito sex

3. Taiwan invests in genetic resource for health

4. Trust and science: the essential elements missing from plastics treaty talks

5. What now for the global plastics treaty?

6. A limerick competition celebrates science through rhyme

7. Plants have a secret language that scientists are only now starting to decipher

8. Environmental treaties are paralysed — here’s how we can do better

9. Ethics must keep pace with embryo research

10. Treat children as citizen co-researchers in health technology

11. Universities can harness AI to make learning intuitive

12. Don’t overlook the plastic footprint of fireworks

13. All-perovskite tandem solar cells with dipolar passivation

14. A matrix-confined molecular layer for perovskite photovoltaic modules

15. Direct deaminative functionalization with N-nitroamines

16. Preserving Pompeii’s past, one step at a time

17. This ‘minor’ bird flu strain has potential to spark human pandemic

18. AI can supercharge inequality — unless the public learns to control it

19. How to understand exoplanets — space scientists call on lab-based chemists to help

20. How do you know what I know you know? Steven Pinker on common knowledge

21. Daily briefing: Key coral species are functionally extinct after record-breaking heatwave

22. China seeks self-reliance in science in next five-year plan

23. The sci-fi films that physicists love to watch

24. How Napoleon’s army met its doom: DNA reveals surprise illnesses had a role

25. Chen-Ning Yang obituary: intuitive physicist whose theories on broken symmetries were proved right

26. Sugarcane genomes offer sweet surprise: mystery ancestor

27. Ancient graffiti and brain complexities: Books in brief

28. How to grow crystals when and where you want them

29. Daily briefing: People with cancer lived longer if they’d had a COVID-19 vaccine

30. AI chatbots are sycophants — researchers say it''s harming science

31. Audio long read: How to get the best night’s sleep — what the science says

32. Paper or plastic?

33. These iconic corals are nearly extinct due to heatwaves: can they be saved?

34. This AI method could turbocharge the hunt for new medicines

35. Does gravity produce quantum weirdness? Proposal divides physicists

36. This luxury ‘cat poo’ coffee has a unique flavour: what’s behind it?

37. Daily briefing: Stinkbugs nurture fungi in a newly discovered organ

38. Daily briefing: People with macular degeneration can read again after retinal implant

39. Google Scholar tool gives extra credit to first and last authors

40. Google AI aims to make best-in-class scientific software even better

41. Author Correction: Structures of α-synuclein filaments from multiple system atrophy

42. Surprise meteorite debris uncovered on Moon’s far side

43. Google claims ‘quantum advantage’ again — but researchers are sceptical

44. Gene implicated in the heart defects associated with Down’s syndrome

45. Is there a ‘smoking gun’ test for quantum gravity?

46. AI discovers learning algorithm that outperforms those designed by humans

47. Evolutionary history of stony corals suggests that some could be resilient to climate change

48. Tumours might be sensitized to immune therapy by COVID mRNA vaccines

49. People with some cancers live longer after a COVID vaccine

50. Copper-free chips generate robust ‘combs’ of multicoloured light

51. Neuroendocrine control of calcium mobilization in the fruit fly

52. Video‐rate tunable colour electronic paper with human resolution

53. Integration of hunger and hormonal state gates infant-directed aggression

54. Non-van der Waals superlattices of carbides and carbonitrides

55. Observation of constructive interference at the edge of quantum ergodicity

56. Bottom-up design of Ca2 channels from defined selectivity filter geometry

57. Cryogenic X-ray photoelectron spectroscopy for battery interfaces

58. Mapping Plasmodium transitions and interactions in the Anopheles female

59. Joint neutrino oscillation analysis from the T2K and NOvA experiments

60. A global coral phylogeny reveals resilience and vulnerability through deep time

61. SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade

62. Designing allosteric modulators to change GPCR G protein subtype selectivity

63. Transcriptional interferences ensure one olfactory receptor per ant neuron

64. A circular economy approach for the global lithium-ion battery supply chain

65. Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21

66. Oxidative potential of atmospheric particles in Europe and exposure scenarios

67. A metallic p-wave magnet with commensurate spin helix

68. Deterministic soliton microcombs in Cu-free photonic integrated circuits

69. Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion

70. Optimization by decoded quantum interferometry

71. Classical theories of gravity produce entanglement

72. Uncertain climate effects of anthropogenic reactive nitrogen

73. Honey, I ate the kids: how hunger and hormones make mice aggressive

74. Reply to: Uncertain climate effects of anthropogenic reactive nitrogen

75. Discovering state-of-the-art reinforcement learning algorithms

76. Measles, polio, tuberculosis: what’s causing spikes in infectious diseases?

77. Four game-changing immunology tools to watch

78. We need more than good science to fight infectious disease

79. Here there be

80. The search for mutations that sperm acquire as men age

81. Sex differences in depression revealed by large genetics study

82. Pancreatic cancer relies on opposing signalling pathways to drive its cellular diversity

83. How to spot fake scientists and stop them from publishing papers

84. What makes PhD students happy? Good supervision

85. US PhD admissions shrink as fears over Trump’s cuts take hold

86. ‘Gland-in-a-dish’ secretes stress hormone like the real thing

87. Stinkbug ‘ear’ actually hosts parasite-fighting fungi

88. Hopes of realizing a dream ‘city of health’

89. Daily briefing: Time to retire the Turing test?

90. Universities are embracing AI: will students get smarter or stop thinking?

91. Cake to the rescue: how these PhD students are cooking up a sense of community

92. The TrumpRx website won’t slash drug prices — but this will

93. Genetics can give evolving societies a leg up

94. The race for deep-sea minerals could cause geopolitical and ecological harm

95. Take the time to ensure that AI is safe

96. Brazil must beef up its COP30 scheme to preserve tropical forests

97. Breastfeeding boosts immune cells that protect against breast cancer

98. How scientists are pushing back against Trump’s funding ‘deal’ for universities

99. People with blindness can read again after retinal implant

100. What’s the cap on human energy expenditure? Elite athletes reveal ‘metabolic ceiling’

101. Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers

102. Parity and lactation induce T cell mediated breast cancer protection

103. Selective Methylene Oxidation in α,β-Unsaturated Carbonyl Natural Products

104. Are these the happiest PhD students in the world?

105. Why we still don’t understand the Universe — even after a century of dispute

106. Disconnecting part of the brain sends it into a deep sleep

107. Cold plunge: how I gained hands-on experience in marine biology

108. Daily briefing: Gene that causes obesity also shields against heart disease

109. Daily briefing: How the brain locks in long-term memories

110. Alternatives to animal testing are the future — it’s time that journals, funders and scientists embrace them

111. AI language models killed the Turing test: do we even need a replacement?

112. Why simply ending animal testing isn’t the answer in biomedical research

113. John Gurdon obituary: Biologist who made cloning possible

114. Author Correction: A room temperature rechargeable all-solid-state hydride ion battery

115. Blood tests are now approved for Alzheimer’s: how accurate are they?

116. Would ChatGPT hire you? Your age and gender matter

117. Is academic research becoming too competitive? Nature examines the data

118. Warning signs

119. Time-resolved fluorescent proteins expand the microscopy palette

120. This gene causes obesity — and shields against heart disease

121. The US and Europe have cut billions in health aid — can anyone fill the gap?

122. The problem with career planning in science

123. Parenting, illnesses and medical commitments: the private details grant reviewers shouldn’t need to know

124. Daily briefing: Making babies with lab-grown eggs and sperm

125. Mysterious ‘little red dots’ are baffling astronmers. What are they?

126. Ion stencils used for synthesis of patchy nanoparticles

127. Yeast genomes show how large genomic variations affect trait diversity

128. First known fossil hand of the hominin Paranthropus boisei

129. Using heat to power up molecular systems

130. Extreme confinement unleashes water’s hidden electrical capabilities

131. How emotional memories are engraved on the brain, with surprising helper cells

132. The evolution of facultative symbiosis in stony corals

133. Efficient quantum thermal simulation

134. Spatial metabolic gradients in the liver and small intestine

135. Hijacking a bacterial ABC transporter for genetic code expansion

136. From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes

137. New fossils reveal the hand of Paranthropus boisei

138. Niche-specific dermal macrophage loss promotes skin capillary ageing

139. A long-necked early dinosaur from a newly discovered Upper Triassic basin in the Andes

140. Aboveground biomass in Australian tropical forests now a net carbon source

141. Integrated lithium niobate photonics for sub-ångström snapshot spectroscopy

142. A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization

143. Patchy nanoparticles by atomic stencilling

144. Modern sea-level rise breaks 4,000-year stability in southeastern China

145. In-plane dielectric constant and conductivity of confined water

146. Population-specific polygenic risk scores for people of Han Chinese ancestry

147. Isolation, engineering and ecology of temperate phages from the human gut

148. A vaccine central in A(H5) influenza antigenic space confers broad immunity

149. The astrocytic ensemble acts as a multiday trace to stabilize memory

150. The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies

151. New bird flu vaccine could tackle multiple variants with one shot

152. Tin-based perovskite solar cells with a homogeneous buried interface

153. Photocatalytic oxygen-atom transmutation of oxetanes

154. Deaminative cross-coupling of amines by boryl radical β-scission

155. Wastewater treatment produces surprising amounts of greenhouse gases

156. The year of the Ghost Ant

157. How journals can break down barriers for Latin American scientists

158. Daily briefing: Could microbe-friendly buildings help us be healthier?

159. UNESCO stands at a crossroads — researchers must back its new leader

160. The quest to make babies with lab-grown eggs and sperm

161. Scientists lose jobs and grants as US government shutdown takes a toll

162. AI bots wrote and reviewed all papers at this conference

163. Gigantic black holes did not have starring role in early cosmic transition

164. The spectre of malnutrition is back and must be tackled — fast

165. Daily briefing: Corals have been pushed beyond an irreversible tipping point, says report

166. Japan declares a flu epidemic — what this means for other nations

167. Do rats double-dip food with their tails?

168. The race to uncover snow’s many mysteries before it disappears forever

169. Inside our university’s mission to pivot to research

170. The probiotic home: where microbes are welcome guests

171. Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier

172. Carbon credits are failing to help with climate change — here’s why

173. Longer grant cycles would boost research in Africa

174. AI’s therapeutic potential goes beyond emotional connection

175. Brazil’s COP30 legacy should be to protect more of its forests

176. Red lines for religious AI

177. Men’s brains shrink faster than women’s: what that means for Alzheimer’s

178. Economics Nobel prize won by researchers who showed how science boosts growth

179. ‘Am I redundant?’: how AI changed my career in bioinformatics

180. What an academic misconduct accusation taught me about sharing research

181. Host cell Z-RNAs activate ZBP1 during virus infections

182. Birds’ intruder alert hints at how sounds took on new meanings

183. Andean peoples hunted and gathered long after they embraced farming

184. Defending Ohuira Bay, Mexico

185. Metals are key to the global economy — but three challenges threaten supply chains

186. Digital flocks, predators allow ecologists to simulate real-world animal behaviour

187. Daily briefing: Don''t sideline Palestinian scientists after ceasefire, say experts

188. Alchemy: discredited pseudoscience or chemistry’s worthy ancestor?

189. Coral die-off marks Earth’s first climate ‘tipping point’, scientists say

190. Should genetically modified wildlife be banned? Scientists weigh the risks

191. The world’s first plastics treaty is in crisis: can it be salvaged?

192. Current mosquitoes evolved more recently than previously thought

193. Portable muon beam could accelerate archaeology scans

194. Dangerous ‘nitazene’ opioids are on the rise: researchers are worried

195. European bats capture migrating birds and eat them on the wing

196. Future solitude

197. Author Correction: Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus

198. Daily briefing: Chronic pain linked to small cluster of brain cells

199. Rebuilding Gaza: don''t sideline Palestinian scientists, say experts

200. Naked mole rats live for decades — genetic tweaks reveal insights into ageing

201. More than 30% of this century’s science Nobel prizewinners immigrated: see their journeys

202. This list of non-negotiables helped me to defeat PhD-student guilt

203. How to pause and restart your science career

204. First proposed blood test for chronic fatigue syndrome: what scientists think

205. Daily briefing: Chemistry Nobel for ‘super sponge’ MOFs

206. Mark Norell obituary: palaeontologist who showed that dinosaurs still walk among us — as birds

207. Hippos still roamed Europe during the last ice age

208. ‘Google for DNA’ brings order to biology’s big data

209. How stereotypes shape AI – and what that means for the future of hiring

210. Distorted representations of age and gender are reflected in AI models

211. Drones switch payloads in mid-air using a flying toolbox

212. Sacrificial metal speeds up synthesis of nano-alloys from multiple elements

213. A quantum boost for ultra-precise clocks

214. Ultra-sensitive DNA sequencing maps mutations that precede cancer

215. Tracing the ancestry of barley in time and space

216. Brain area linked to chronic pain discovered — offering hope for treatments

217. Flexible perceptual encoding by discrete gamma events

218. Programmable on-chip nonlinear photonics

219. KCTD10 is a sensor for co-directional transcription–replication conflicts

220. Quantum-amplified global-phase spectroscopy on an optical clock transition

221. Sex and smoking bias in the selection of somatic mutations in human bladder

222. Southward impact excavated magma ocean at the lunar South Pole–Aitken basin

223. A ductile chromium–molybdenum alloy resistant to high-temperature oxidation

224. Sperm sequencing reveals extensive positive selection in the male germline

225. Efficient and accurate search in petabase-scale sequence repositories

226. Somatic mutation and selection at population scale

227. A full-featured 2D flash chip enabled by system integration

228. Age and gender distortion in online media and large language models

229. Hotspots of human mutation point to clonal expansions in spermatogonia

230. A parabrachial hub for need-state control of enduring pain

231. Enzyme specificity prediction using cross attention graph neural networks

232. Daily briefing: Physics Nobel for quantum tunnelling on a macroscopic scale

233. Daily briefing: Nobel Prize for discovery of ‘brake’ on immune system

234. The girl who used to be my sister

235. Low quality papers are flooding the cancer literature — can this AI tool help to catch them?

236. Clues to why the weight-loss condition cachexia arises when cancer occurs

237. Chemistry Nobel for scientists who developed massively porous ‘super sponge’ materials

238. AI models that lie, cheat and plot murder: how dangerous are LLMs really?

239. These immune cells won Nobel fame — can they solve autoimmune disease?

240. The rise of ‘nightmare bacteria’: antimicrobial resistance in six charts

241. The EU’s Horizon research fund needs to stay a defence-free zone

242. The 1975 discovery of long-lost letters between Albert Einstein and the astronomer Willem de Sitter

243. Groundbreaking quantum-tunnelling experiments win physics Nobel

244. Customizable AI systems that anyone can adapt bring big opportunities — and even bigger risks

245. Stop treating code like an afterthought: record, share and value it

246. Incentives accelerate progress on open access in Spain

247. Microbe discovery holds promise for sustainable biotechnology

248. Stop destructive fishing in marine protected areas

249. Insect biodiversity monitoring must be expanded

250. Prizes must recognize machine contributions to discovery

251. Volunteer scientists work ‘nights and weekends’ to guide vaccine advice in US

252. Wonder, empathy, life: why we called our pregnancy-diagnostic company Mirvie

253. Connecting the dots: I trace the history of the East Kolkata Wetlands

254. Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’

255. The cutting-edge medical approaches that could transform ageing

256. Jane Goodall obituary: pioneer primatologist who inspired generations of scientists

257. 27 things we wish we’d known when we started our PhDs

258. Daily briefing: The Nobel prizes’ most prestigious rivals

259. From fossil fuels to ‘green capitalism’: the dilemmas of a just energy transition

260. Will AI ever win its own Nobel? Some predict a prize-worthy science discovery soon

261. A scientist’s guide to AI agents — how could they help your research?

262. Creative hobbies could slow brain ageing at the molecular level

263. ‘Rogue’ planet is fastest-growing ever observed

264. Weaponizing uncertainty in science and in public health puts people in harm’s way

265. First human transplant of kidney modified to have ‘universal’ blood type

266. Author Correction: Ribonucleotide incorporation into mitochondrial DNA drives inflammation

267. These science prizes want to rival the Nobels: how do they compare?

268. Marcus kinetics control singlet and triplet oxygen evolving from superoxide

269. The child of humanity becomes the mother of all

270. AI has designed thousands of potential antibiotics. Will any work?

271. Violin therapy: Books in brief

272. Daily briefing: ‘A messenger of hope’ — Jane Goodall’s impact on science

273. These alien planets are astronomers’ favourites: here’s why

274. Biothreat hunters catch dangerous DNA before it gets made

275. Scooped by a cupcake business: why we called our green-cement company Sublime Systems

276. Author Correction: EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells

277. Research assessment: a round-up for early-career researchers

278. Publisher Correction: Multimodal cell maps as a foundation for structural and functional genomics

279. Keep, lose, add: a checklist for plotting your next career move in science

280. Memorable, distinctive, not too ‘sciencey’: why we named our biotech firm Anocca

281. Exclusive: ex-CDC director talks about why she was fired

282. Model organism databases face budget cuts and closures

283. Jane Goodall’s legacy: three ways she changed science

284. Daily briefing: Fireworks in space — the month’s best science images

285. This US government shutdown is different: what it means for science

286. DNA circuits store data — with heat as their power source

287. Early- and late-diagnosed autism are genetically distinct

288. Parachutes inspired by the Japanese art of kirigami

289. Bacteria use a decoy defence molecule to set a trap for viruses

290. Ancient viral DNA in the human genome shapes early development

291. Quantum correlations enhance the sensitivity of room-temperature sensors

292. Features of autism can affect age of diagnosis – and so can genes

293. Machine learning matches enzymes with molecular substrates

294. Mix-and-match fossils tell the tale of snake and lizard evolution

295. A pathway that controls conversion of the amino acid cysteine into a cholesterol regulator

296. Elaborate machinery for inserting proteins into the outer membrane of bacteria

297. Evolution of drug-resistant ovarian-cancer clones tracked in patients

298. End GDP mania: how the world should really measure prosperity

299. Spin squeezing in an ensemble of nitrogen–vacancy centres in diamond

300. Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis