1. How obesity drugs quiet ‘food noise’ in the brain

2. The apple of my eye: How I’ve created a plant-health tracker for farmers in Tanzania

3. On the move: why PhD students study abroad in 2025

4. George Smoot obituary: Charismatic cosmologist who revealed ripples in the Big Bang’s afterglow

5. Why space exploration needs science leadership now — before it’s too late

6. How COVAX raced to protect the world from COVID-19

7. Daily briefing: How ancient humans bred and traded dogs

8. Author Correction: Mechanisms of stretch-mediated skin expansion at single-cell resolution

9. Who will fill the climate-data void left by the Trump administration?

10. Three research stars fighting to protect coastlines

11. Sinking cities: how China is moving subsidence research forward

12. The leading cities in the world for high-quality research in 2024

13. Why coastal megacities should look inland for research collaborations

14. ‘Malicious use is already happening’: machine-learning pioneer on making AI safer

15. The future of AI

16. A Chinese AI model taught itself basic physics — what discoveries could it make?

17. Why I moved my research to China from Germany: a biologist’s experience

18. Spaceport mementos

19. Daily briefing: Greenhouse-gas emissions should peak by 2030, say researchers

20. Volcano mega-eruptions lead to parched times

21. How ancient humans bred and traded the first domestic dogs

22. Tiny robots swim through blood, deliver drugs — and then dissolve

23. James Watson obituary: co-discoverer of DNA’s double helix who reshaped modern biology

24. Pig-organ transplants are often rejected — researchers find a way to stop it

25. CRISPR vs cholesterol: can gene editing prevent heart disease?

26. Physiology and immunology of pig-to-human decedent kidney xenotransplant

27. Multi-omics analysis of a pig-to-human decedent kidney xenotransplant

28. Could China’s cautious new research strategy stifle its science-leadership ambitions?

29. ''Tiny'' AI model beats massive LLMs at logic test

30. The US government shutdown is over: what’s next for scientists

31. Researching sustainable food production, with help from the cows

32. Global greenhouse-gas emissions are still rising: when will they peak?

33. First new type of malaria treatment in decades shows promise against drug resistance

34. Magnetic fibres give this robot a soft grip

35. Can UK science really spawn a 1-trillion company?

36. Metabolite maps reveal spatial gradients in liver and intestinal tissue

37. Official statistics are vastly undercounting deaths from extreme weather

38. Ultrathin films of a 2D polymer provide airtight seal

39. Material system enhances superconducting qubits

40. Extreme rainfall poses the biggest risk to Mumbai’s most vulnerable people

41. SIGLEC12 mediates plasma membrane rupture during necroptotic cell death

42. Convergent genome evolution shaped the emergence of terrestrial animals

43. iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion

44. Radio burst from a stellar coronal mass ejection

45. Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis

46. GREGoR: accelerating genomics for rare diseases

47. Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

48. A molecularly impermeable polymer from two-dimensional polyaramids

49. An ancient recombination desert is a speciation supergene in placental mammals

50. Synthesis of enantioenriched atropisomers by biocatalytic deracemization

51. Rare genetic variants confer a high risk of ADHD and implicate neuronal biology

52. Silicon solar cells with hybrid back contacts

53. A universal speed limit for spreading of coherence

54. Photoinduced twist and untwist of moiré superlattices

55. Aligning machine and human visual representations across abstraction levels

56. Mortality impacts of rainfall and sea-level rise in a developing megacity

57. The contribution of rock strength to soil production

58. Florigen activation complex forms via multifaceted assembly in Arabidopsis

59. Spatial fibroblast niches define Crohn’s fistulae

60. Estimation and mapping of the missing heritability of human phenotypes

61. Ecology and spread of the North American H5N1 epizootic

62. In situ structural mechanism of epothilone-B-induced CNS axon regeneration

63. Controlling pyramidal nitrogen chirality by asymmetric organocatalysis

64. Dye or die: bacterium forced to make pigment to stay alive

65. Huge eruption on a distant star confirmed at last

66. Emerging climate impact on carbon sinks in a consolidated carbon budget

67. Olympiad-level formal mathematical reasoning with reinforcement learning

68. Potent neutralization of Marburg virus by a vaccine-elicited antibody

69. Mathematicians put AI model AlphaProof to the test

70. Fossilized technology: Books in brief

71. Three rising stars in ageing research

72. Is ageing a disease? The debate that could reshape medicine

73. Could humans live to 150? Why some researchers think we’re on the cusp of a major longevity breakthrough

74. The future of ageing: science aims to deliver another leap in lifespan

75. Hotcakes at the end times

76. “It keeps me awake at night”: machine-learning pioneer on AI’s threat to humanity

77. ‘Godfather of AI’ becomes first person to hit one million citations

78. How geopolitics is reshaping research: Data hint at shifting collaborations

79. How much protein do you really need? What the science says

80. Daily briefing: The Americas have lost their measles elimination status

81. Chinese researchers reveal unexplored section of mysterious Arctic Ocean ridge

82. To reform universities, first tackle global rankings

83. Daily briefing: The complex legacy of James Watson

84. Gut bacteria help mice to stay lean

85. Money and power underlie mysterious Andean ‘band of holes’

86. Author Correction: Learning the natural history of human disease with generative transformers

87. Influential list of highly cited researchers now shuts out more scientists: here’s why

88. Is HRT in menopause healthy? US label change triggers debate

89. I have Einstein, Bohr and Feynman in my pocket

90. Lessons from a long road to a first-author paper

91. Ethically sourced image data set encourages fairness in AI research

92. High performance tandem perovskite LEDs through interlayer photon recycling

93. Comprehensive echocardiogram evaluation with view primed vision language AI

94. ‘Almost utopian’: how protecting the environment is boosting the economy in Brazil

95. Failure is not an option for Africa’s newly launched medicines agency

96. Insatiable squirrel ravages cherry blossoms for breakfast

97. For real climate action, empower women

98. Be rational: chimp decision-making is guided by the strongest evidence

99. China’s new scientist visa is a ‘serious bid’ for the world’s top talent

100. The computers that run on human brain cells

101. How genetically encoded sensors have lit up neuroscience

102. Academic freedom is key to the future of universities

103. Kenya’s black rhino revival is a story of hope for conservationists

104. COP meetings must evolve to turn climate promises into action

105. Partnerships between academia and industry must serve the public good

106. Vaccine advice: how a US centre is filling growing gaps in public-health information

107. Want a younger brain? Learn another language

108. Flexible perovskite/silicon tandem solar cell with a dual buffer layer

109. A fault-tolerant neutral-atom architecture for universal quantum computation

110. Flexible perovskite/silicon tandem solar cells with 33.6% efficiency

111. Author Correction: The oldest known lepidosaur and origins of lepidosaur feeding adaptations

112. Witnessing chamois populations recover

113. Rebuilding Ukraine — one university’s bold vision

114. Don’t despair, collective action can address climate change

115. Hamilton Smith obituary: molecular biologist who co-discovered precise molecular scissors for cutting DNA

116. Africa finally has its own drug-regulation agency — and it could transform the continent’s health

117. Publisher Correction: Radiation-induced amphiregulin drives tumour metastasis

118. Daily briefing: A ‘Google Maps’ for Roman roads

119. Daily briefing: ‘Mind captioning’ AI describes the images in your head

120. Antibodies unleashed against pancreatic cancer

121. DNA pioneer James Watson has died ― colleagues wrestle with his legacy

122. International PhD student numbers in US hold steady — for now

123. Surprise ‘tail’ found on an iconic galaxy may rewrite its history

124. A host of ‘exocomets’ swarms a distant star

125. Preprint site arXiv is banning computer-science reviews: here’s why

126. Pressure to publish is rising as research time shrinks, finds survey of scientists

127. How scientists exposed to other people’s trauma find support

128. Outside the window

129. Author Correction: TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2

130. First ever atlas of brain development shows how stem cells turn into neurons

131. ‘Google Maps’ for Roman roads reveals vast extent of ancient network

132. An ATP-gated molecular switch orchestrates human messenger RNA export

133. Author Correction: The emergence of transcriptional identity in somatosensory neurons

134. Shadow scholars: inside Kenya’s multibillion-dollar fake-essay industry

135. Daily briefing: UK science is ‘bleeding to death’, says report

136. ‘Mind-captioning’ AI decodes brain activity to turn thoughts into text

137. Developmental maps of the brain trace when cell types emerge

138. Images for AI use can be sourced responsibly

139. Most Antarctic ice shelves are set to disappear if greenhouse-gas emissions remain high

140. Ultrashort laser pulse amplified by back-and-forth propagation

141. Adenosine signalling drives antidepressant actions of ketamine and ECT

142. Transcriptomic and spatial organization of telencephalic GABAergic neurons

143. Millisecond lifetimes and coherence times in 2D transmon qubits

144. Specificity, length and luck drive gene rankings in association studies

145. The importance of past rifting in large igneous province development

146. Spatial dynamics of brain development and neuroinflammation

147. A probabilistic histological atlas of the human brain for MRI segmentation

148. Anti-progestin therapy targets hallmarks of breast cancer risk

149. Eight millennia of continuity of a previously unknown lineage in Argentina

150. Two residues reprogram immunity receptors for nitrogen-fixing symbiosis

151. Conservation and alteration of mammalian striatal interneurons

152. Structural snapshots capture nucleotide release at the μ-opioid receptor

153. Continuous cell-type diversification in mouse visual cortex development

154. Lineage-resolved atlas of the developing human cortex

155. Atomically accurate de novo design of antibodies with RFdiffusion

156. Lymphoid gene expression supports neuroprotective microglia function

157. Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology

158. Global satellite survey reveals uncertainty in landfill methane emissions

159. Fair human-centric image dataset for ethical AI benchmarking

160. Lymph node environment drives FSP1 targetability in metastasizing melanoma

161. The new frontier in understanding human and mammalian brain development

162. Vector-stimuli-responsive magnetorheological fibrous materials

163. Assessing phylogenetic confidence at pandemic scales

164. Secretome translation shaped by lysosomes and lunapark-marked ER junctions

165. Targeting FSP1 triggers ferroptosis in lung cancer

166. Dispersion-engineered multipass optical parametric amplification

167. Meet the ‘Wee-rex’. Tiny tyrannosaur is its own species

168. Myriad Aryne Derivatives from Carboxylic Acids

169. Anosophoros

170. Chinese scientists increasingly lead joint projects with the UK, US and Europe

171. Daily briefing: A guide to global climate change action

172. Can AI be truly creative?

173. Antibody drugs show promise for treating bird flu and HIV

174. Single video camera tells the story of deadly Myanmar quake

175. How I’m helping to cultivate science entrepreneurship in Brazil

176. Biggest black-hole outburst ever seen records death throes of a star

177. From the archive: Do sunspots affect the price of corn?

178. COVID-19 is spreading again — how serious is it and what are the symptoms?

179. The ‘implementation COP’: why the Belém summit must ratchet up climate action

180. Daily briefing: Custom-made gene-editing therapy for children to enter clinical trial

181. Japan’s first female prime minister doesn’t call herself a feminist — but the country needs her to tackle sexism in science

182. How the rush for critical minerals is neglecting human needs

183. Climate change is devastating mining of minerals needed to fight it

184. China should undertake more risky research to close the Nobel gap

185. Can AI predict and limit online hate?

186. When will Africa have a Nobel prize in medicine?

187. Safeguards for virology must be designed in partnership with the public

188. ‘Memory foam’ skeleton in cells helps them to navigate

189. Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome

190. My funding applications are taking up too much time. How can I stay focused on my research?

191. Alzheimer’s decline slows with just a few thousand steps a day

192. How to fight climate change without the US: a guide to global action

193. Accelerating the discovery of multicatalytic cooperativity

194. From pangolins to primates: how I use zoo facilities to treat wild animals

195. ‘Biotech Barbie’ says the time has come to consider CRISPR babies. Do scientists agree?

196. PhD training needs a reboot in an AI world

197. Dismantling of US federal agencies will ‘destroy science’

198. Daily briefing: Wildlife wonders and a Super Heavy — the month’s best science images

199. Sex, drugs and the conscious brain: Francis Crick beyond the double helix

200. By the time you hear these bats, it’s too late

201. Longer walks beat shorter strolls for heart health

202. Powerful new antibiotic that can kill superbugs discovered in soil bacteria

203. Personalized gene editing helped one baby: can it be rolled out widely?

204. Daily briefing: The bowhead whale’s secret to living to 200

205. Daily briefing: How the plastics-treaty breakdown could pave the way for something better

206. Artificial brains with less drain

207. Secret route to warm cosmic ‘inflation’: the nuclear force

208. Forests’ misty breath sustains crops in distant lands

209. Why India’s controversial ‘cloud seeding’ trial failed to make it rain

210. Too much social media gives AI chatbots ‘brain rot’

211. Please stay out of the abandoned buildings

212. Nanotyrannus and Tyrannosaurus coexisted at the close of the Cretaceous

213. Author Correction: Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche

214. Hotly debated dinosaur is not a tiny T. rex after all

215. T. rex debate settled: contested fossils are smaller rival species, not juveniles

216. ‘Teenage T. rex’ fossil is actually a different species

217. Experiments reveal extreme water generation during planet formation

218. Can IVF save the northern white rhino from extinction? — October’s best science images

219. This ‘impressive’ AI model predicted Hurricane Melissa’s perilous growth

220. What changing energy flows reveal about Africa’s ecosystems

221. This whale lives for centuries: its secret could help extend human lifespan

222. Electronic paper could enable virtual reality with human-eye resolution

223. To make water, exoplanets might just need some pressure

224. Treatment made that is effective against a wide range of snake venoms

225. Molecular ‘glues’ and ‘bumpers’ on receptors can bias signalling inside the cell

226. Wildfire smoke and its harmful effects will worsen with climate change

227. Ultrasound-driven artificial muscles can grasp, flex and swim

228. Electromagnetic interference shielding using metal and MXene thin films

229. Origins of chromosome instability unveiled by coupled imaging and genomics

230. Technological pathways for cost-effective steel decarbonization

231. Magnetotelluric evidence for a melt-rich magmatic reservoir beneath Mayotte

232. Multiple LDLR family members act as entry receptors for yellow fever virus

233. Energy flows reveal declining ecosystem functions by animals across Africa

234. Multi-omic profiling reveals age-related immune dynamics in healthy adults

235. Sensory expectations shape neural population dynamics in motor circuits

236. Ultrasound-driven programmable artificial muscles

237. Mechanism of conductance control and neurosteroid binding in NMDA receptors

238. A pangenome and pantranscriptome of hexaploid oat

239. Helicase-mediated mechanism of SSU processome maturation and disassembly

240. Ocean warming threatens the viability of 60% of Antarctic ice shelves

241. Plug-in strategy for resistance engineering inspired by potato NLRome

242. Many-body interference in kagome crystals

243. Building wet planets through high-pressure magma–hydrogen reactions

244. Thiorphan reprograms neurons to promote functional recovery after spinal cord injury

245. Evidence for improved DNA repair in long-lived bowhead whale

246. A ductile solid electrolyte interphase for solid-state batteries

247. Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites

248. Atomically resolved edges and defects in lead halide perovskites

249. Reply to: Carbon implications of wood harvesting and forest management

250. Bowhead whales can live for more than 200 years — this protein might be why

251. Single antivenom protects against 17 different snakebites

252. Carbon implications of wood harvesting and forest management

253. On anisotropy in cubic Cu2O photoelectrodes

254. Reply to: On anisotropy in cubic Cu2O photoelectrodes

255. World’s smallest 3D bioprinter could help surgeons repair vocal cords

256. How nanobots are accelerating cancer-targeting therapies

257. ‘A real risk’: the rise of weapons that can act alone

258. Why we should limit the autonomy of AI-enabled weapons

259. Komorebi

260. Policed and censored: professors in the southern US feel under siege

261. We need a new Turing test to assess AI’s real-world knowledge

262. From MRI to Ozempic: breakthroughs that show why fundamental research must be protected

263. 7 basic science discoveries that changed the world

264. Retraction Note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

265. Daily briefing: The secret language of plants

266. Daily briefing: Surprise illnesses had a role in the demise of Napoleon’s army

267. Open-source protein structure AI aims to match AlphaFold

268. Glowing sperm helps to reveal secrets of mosquito sex

269. Taiwan invests in genetic resource for health

270. Trust and science: the essential elements missing from plastics treaty talks

271. What now for the global plastics treaty?

272. A limerick competition celebrates science through rhyme

273. Plants have a secret language that scientists are only now starting to decipher

274. Environmental treaties are paralysed — here’s how we can do better

275. Ethics must keep pace with embryo research

276. Treat children as citizen co-researchers in health technology

277. Universities can harness AI to make learning intuitive

278. Don’t overlook the plastic footprint of fireworks

279. All-perovskite tandem solar cells with dipolar passivation

280. A matrix-confined molecular layer for perovskite photovoltaic modules

281. Direct deaminative functionalization with N-nitroamines

282. Preserving Pompeii’s past, one step at a time

283. This ‘minor’ bird flu strain has potential to spark human pandemic

284. AI can supercharge inequality — unless the public learns to control it

285. How to understand exoplanets — space scientists call on lab-based chemists to help

286. How do you know what I know you know? Steven Pinker on common knowledge

287. Daily briefing: Key coral species are functionally extinct after record-breaking heatwave

288. China seeks self-reliance in science in next five-year plan

289. The sci-fi films that physicists love to watch

290. How Napoleon’s army met its doom: DNA reveals surprise illnesses had a role

291. Chen-Ning Yang obituary: intuitive physicist whose theories on broken symmetries were proved right

292. Sugarcane genomes offer sweet surprise: mystery ancestor

293. Ancient graffiti and brain complexities: Books in brief

294. How to grow crystals when and where you want them

295. Daily briefing: People with cancer lived longer if they’d had a COVID-19 vaccine

296. AI chatbots are sycophants — researchers say it''s harming science

297. Audio long read: How to get the best night’s sleep — what the science says

298. Paper or plastic?

299. These iconic corals are nearly extinct due to heatwaves: can they be saved?

300. This AI method could turbocharge the hunt for new medicines