1. Trump’s science advisers: how they could influence his second presidency

2. RNA molecule rejuvenates ageing mice by restoring old cells

3. How to trick the immune system into attacking tumours

4. Revealed: Why the fatal Huntington’s gene takes so long to cause harm

5. Daily briefing: AI-designed proteins offer lifeline for treating snake bites

6. How to be a brilliant ally to your neurodivergent lab mate

7. Mines for a clean-energy metal have a surprise climate effect

8. Urban ‘firestorms’: the science behind their ferocious spread

9. Trump will weaken climate action — the rest of the US must not follow suit

10. Brain-wide neuronal circuit connectome of human glioblastoma

11. Daily briefing: New obesity definition sidelines BMI to focus on health

12. Championing queer scientists of colour: ‘I don’t think we’ve scratched the surface on systemic exclusion’

13. A generative model for inorganic materials design

14. Hidden tattoos on mummy skin emerge under a laser’s light

15. Meta AI creates speech-to-speech translator that works in dozens of languages

16. Will Europe ramp up defence research? War prompts major rethink

17. Got flu? Promising drug shortens symptoms

18. Author Correction: Evolution of immune genes is associated with the Black Death

19. AI-designed proteins tackle century-old problem — making snake antivenoms

20. Two eighth-century communities near Vienna shared culture but not ancestries

21. Gene drives development of brain’s emotional centre and its connections

22. Imaging reveals how plants cope with salt

23. Striving for open-source and equitable speech-to-speech translation

24. A mutation makes plant roots more welcoming to beneficial microbes

25. The road to CAR-T-cell therapy for lethal childhood brain tumours

26. Women were at the centre of social networks in Iron Age Britain

27. Ancient DNA reveals reproductive barrier despite shared Avar-period culture

28. Cationic peptides cause memory loss through endophilin-mediated endocytosis

29. Specification of claustro-amygdalar and palaeocortical neurons and circuits

30. Joint speech and text machine translation for up to 100 languages

31. Clouds reduce downwelling longwave radiation over land in a warming climate

32. Transducing chemical energy through catalysis by an artificial molecular motor

33. Elemental cryo-imaging reveals SOS1-dependent vacuolar sodium accumulation

34. Widespread occurrence and relevance of phosphate storage in foraminifera

35. Illuminating the multidimensional contributions of small-scale fisheries

36. Methane emissions from the Nord Stream subsea pipeline leaks

37. Autoactive CNGC15 enhances root endosymbiosis in legume and wheat

38. Bilayer nanographene reveals halide permeation through a benzene hole

39. Ensemble reactivations during brief rest drive fast learning of sequences

40. De novo designed proteins neutralize lethal snake venom toxins

41. Long-lived entanglement of molecules in magic-wavelength optical tweezers

42. IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer

43. Targeting FOXM1 condensates reduces breast tumour growth and metastasis

44. Structural insights into RNA cleavage by PIWI Argonaute

45. Massively parallel characterization of transcriptional regulatory elements

46. GZMK-expressing CD8 T cells promote recurrent airway inflammatory diseases

47. The human and non-human primate developmental GTEx projects

48. Prolonged persistence of mutagenic DNA lesions in somatic cells

49. Targeting protein–ligand neosurfaces with a generalizable deep learning tool

50. Continental influx and pervasive matrilocality in Iron Age Britain

51. All-solid-state Li–S batteries with fast solid–solid sulfur reaction

52. Episodic and associative memory from spatial scaffolds in the hippocampus

53. AI-designed antivenoms could help treat lethal snakebites

54. Pathogenesis of bovine H5N1 clade 2.3.4.4b infection in Macaques

55. Engineered enzymes for enantioselective nucleophilic aromatic substitutions

56. Dear Donald Trump: A letter from Nature on how to make science thrive

57. What Trump 2.0 means for science: the likely winners and losers

58. Daily briefing: Pluto-Charon duet started with a gravitational ‘kiss-and-capture’

59. Road trip

60. Two companies launch Moon missions together: will they make history?

61. Author Correction: An endosomal tether undergoes an entropic collapse to bring vesicles together

62. New obesity definition sidelines BMI to focus on health

63. AI-powered contract automation helps research managers level up

64. Has Bluesky replaced X for scientists? Take Nature’s poll

65. How science recruiters and job applicants can get on the same page

66. Do you need extra training before graduate school? Consider a post-baccalaureate position

67. The scientific reason to cook with simmering rather than vigorously boiling water

68. Australia’s social-media ban won’t work — there are better ways to keep kids safe

69. Air pollution and brain damage: what the science says

70. Retractions caused by honest mistakes are extremely stressful, say researchers

71. How to sustain scientific collaboration amid worsening US–China relations

72. Daily briefing: The science behind the deadly Los Angeles firestorm

73. The astonishing scientists who starved to protect plants during the Second World War

74. Remove subsidies to solve India’s fertilizer-overuse problem

75. AlphaFold 3 is great — but it still needs human help to get chemistry right

76. Advising policymakers can’t be taught — researchers must learn by doing

77. Philanthropic foundations must step in to shield science from Trump’s cuts

78. Harsh criticism and unreasonable expectations worsen PhD students’ mental health

79. How should we test AI for human-level intelligence? OpenAI’s o3 electrifies quest

80. Did Pluto ‘kiss and capture’ its largest moon?

81. My work on quantum computing aims to solve the world’s most complex problems

82. Daily briefing: Earth breaches 1.5 C climate limit for the first time

83. ‘Expansion microscopy’ turns ten: how a tissue-swelling method brought super-resolution imaging to the masses

84. PhD parents: the pros and cons of having a child during your doctorate

85. ‘Nicotine Nazis’: the brickbats hurled at scientists researching tobacco’s harms

86. A new vision for how evolution works is long overdue

87. Why a silly-sounding name suits the serious mission of our biotech spin-off

88. Pictograms, comics and other illustrations: Books in brief

89. Facebook to ditch fact-checking: what do researchers think?

90. How the brain cleans itself during deep sleep

91. Voter turnout drives margins of victory ― if elections are fair

92. Earth breaches 1.5 C climate limit for the first time: what does it mean?

93. These are the 20 most-studied bacteria — the majority have been ignored

94. Daily briefing: Meet Punk and Emo, the 430-million-year old mollusc fossils

95. Mind matters: investigating academia’s ‘mental health crisis’

96. Rising stars in AI use robotics and automation to accelerate their work

97. Jimmy Carter obituary: former US president who dedicated his life after office to peace, human rights and global health

98. Repurposing of a gill gene regulatory program for outer ear evolution

99. Study of biologists quitting academia reveals hidden gender gaps

100. Male spiders smell with their legs

101. Revealed: the fatty cells that are the ‘bubble wrap’ of the body

102. Daily briefing: Why kids need to take more risks: science reveals the benefits of adventurous play

103. Why the last cases of sleeping sickness will be the hardest to eliminate

104. Author Correction: Progressive plasticity during colorectal cancer metastasis

105. An early precursor CD8 T cell that adapts to acute or chronic viral infection

106. Crypt density and recruited enhancers underlie intestinal tumour initiation

107. Precursors of exhausted T cells are preemptively formed in acute infection

108. Physicists describe exotic ‘paraparticles’ that defy categorization

109. Author Correction: A deep catalogue of protein-coding variation in 983,578 individuals

110. Cosmic carnage: planetary rubble spotted at a dying star

111. Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes

112. How a small but mighty protein protects a life-sustaining enzyme

113. Human embryo editing against disease is unsafe and unproven — despite rosy predictions

114. We need to talk about human genome editing

115. The AI tool that can interpret any spreadsheet instantly

116. AI learns from chromatin data to uncover gene interactions

117. Spiky fossils Punk and Emo change our understanding of molluscan evolution

118. Circadian rhythms are set by epigenetic marks in neurons

119. Electrochemical synthesis goes wireless

120. New Silurian aculiferan fossils reveal complex early history of Mollusca

121. Particle exchange statistics beyond fermions and bosons

122. A vision–language foundation model for precision oncology

123. Reinventing type 2 immunity in cancer

124. Excitons in the fractional quantum Hall effect

125. Light-harvesting microelectronic devices for wireless electrosynthesis

126. Proximity ferroelectricity in wurtzite heterostructures

127. One-quarter of freshwater fauna threatened with extinction

128. Two-dimensional non-Hermitian skin effect in an ultracold Fermi gas

129. Accurate predictions on small data with a tabular foundation model

130. Site-saturation mutagenesis of 500 human protein domains

131. Molecular and cellular dynamics of the developing human neocortex

132. Sulfide-rich continental roots at cratonic margins formed by carbonated melts

133. A foundation model of transcription across human cell types

134. Structural basis for the conformational protection of nitrogenase from O2

135. Computational microscopy with coherent diffractive imaging and ptychography

136. Complex rearrangements fuel ER and HER2 breast tumours

137. Saturation genome editing-based clinical classification of BRCA2 variants

138. Longitudinal strain enhancement and bending deformations in piezoceramics

139. RNA control of reverse transcription in a diversity-generating retroelement

140. The sequence–structure–function relationship of intrinsic ERα disorder

141. Li2ZrF6-based electrolytes for durable lithium metal batteries

142. Host metabolism balances microbial regulation of bile acid signalling

143. Dynamic supramolecular snub cubes

144. Meta-analysis reveals global variations in plant diversity effects on productivity

145. How frictional ruptures and earthquakes nucleate and evolve

146. Functional evaluation and clinical classification of BRCA2 variants

147. Satellite DNA shapes dictate pericentromere packaging in female meiosis

148. A rare PRIMER cell state in plant immunity

149. Conformational protection of molybdenum nitrogenase by Shethna protein II

150. Janus graphene nanoribbons with localized states on a single zigzag edge

151. Bidirectional histone monoaminylation dynamics regulate neural rhythmicity

152. Hippocampal neuronal activity is aligned with action plans

153. Heritable polygenic editing: the next frontier in genomic medicine?

154. β-CH bond functionalization of ketones and esters by cationic Pd complexes

155. Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation

156. A new-year round-up of the science stories you may have missed

157. Reply to: Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation

158. Paper stars

159. Daily briefing: Why did Europe’s first cities disappear? Uncovering the mysterious Cucuteni–Trypillia culture

160. Why kids need to take more risks: science reveals the benefits of wild, free play

161. Graduate-student stipends in Canada below the poverty line

162. Quantum mechanics 100 years on: an unfinished revolution

163. How quantum mechanics emerged in a few revolutionary months 100 years ago

164. What will viruses do next? AI is helping scientists predict their evolution

165. NASA still has no plan to bring precious Mars rocks to Earth

166. Climate engineering faces hostility— here’s how scientists say it might move forwards

167. Particle accelerators get an assist from AI co-pilots

168. The structure of bad cholesterol comes into focus

169. What do people eat and why do they eat it?

170. Daily briefing: Sleeping mice hint at why new memories don’t overwrite old ones

171. Who built Europe’s first cities? Clues about the urban revolution emerge

172. Researchers: concentrate on bread-and-butter issues to get political buy-in

173. Biodiversity credits are more problematic than carbon credits

174. Science communication has a problem — communication

175. To ensure trust, AI weather-forecast models still need training in physics

176. Earth shattered heat records in 2023 and 2024: is global warming speeding up?

177. ‘WithdrarXiv’ database of 14,000 retracted preprints launches

178. Spacecraft makes closest-ever fly-by of Sun: what the trip will tell us

179. The trill of the chase: recording birdsong in Ireland’s disappearing wilderness

180. ‘One of the last taboos’: breaking the stigma of substance-use disorders in academia

181. Why don’t new memories overwrite old ones? Sleep science holds clues

182. ‘Precocious’ early-career scientists with high citation counts proliferate

183. Author Correction: Ab initio characterization of protein molecular dynamics with AI2BMD

184. Author Correction: Oxidative cyclization reagents reveal tryptophan cation–π interactions

185. Fancy birds decorate nests with a natural pattern: snakeskin

186. Gut lining in pregnant and lactating mice expands to ensure offspring health

187. Direct fabrication of lasers on silicon suggests solution to chip-production problem

188. Paradoxical link between senescent cell state and liver cancer resolved

189. Light turns tiny crystals into force sensors

190. Sleep microstructure organizes memory replay

191. The progression of basaltic–rhyolitic melt storage at Yellowstone Caldera

192. Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis

193. Aspartate signalling drives lung metastasis via alternative translation

194. Learning the fitness dynamics of pathogens from phylogenies

195. A pulsar-like polarization angle swing from a nearby fast radio burst

196. Abrupt changes in biomass burning during the last glacial period

197. Gliomagenesis mimics an injury response orchestrated by neural crest-like cells

198. Structural diversity of axonemes across mammalian motile cilia

199. Magnetospheric origin of a fast radio burst constrained using scintillation

200. Diversity and biogeography of the bacterial microbiome in glacier-fed streams

201. Dysregulation of mTOR signalling is a converging mechanism in lissencephaly

202. Infrared nanosensors of piconewton to micronewton forces

203. Monoallelic expression can govern penetrance of inborn errors of immunity

204. Formation of individual stripes in a mixed-dimensional cold-atom Fermi–Hubbard system

205. Non-Abelian lattice gauge fields in photonic synthetic frequency dimensions

206. Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice

207. A collicular map for touch-guided tongue control

208. High-resolution genomic history of early medieval Europe

209. FBP1 controls liver cancer evolution from senescent MASH hepatocytes

210. Upconverting microgauges reveal intraluminal force dynamics in vivo

211. Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance

212. GaAs nano-ridge laser diodes fully fabricated in a 300-mm CMOS pilot line

213. Limitations of ice cores in reconstructing temperature seasonality

214. Reply to: Limitations of ice cores in reconstructing temperature seasonality

215. Science in 2025: what to expect this year

216. Countdown to a nuclear clock: a three minute guide

217. Of your own device

218. The case for Latin to communicate science

219. How AI is unlocking ancient texts — and could rewrite history

220. Apply the legal ‘true malice’ principle to protect research-misconduct sleuths

221. To solve the global wildfire crisis, don’t just focus on flames

222. One way to find mental-health support when professional help is not available

223. Chinese rice actually tastes ever more nice

224. 2025 must be the year when the rules of global finance are reformed

225. Audio long read: How a silly science prize changed my career

226. The Nature Podcast highlights of 2024

227. ''CAR T cells'': a festive parody song from the Nature Podcast

228. ‘Ozempic, you’re able’: a festive parody song from the Nature Podcast

229. Steering perovskite precursor solutions for multijunction photovoltaics

230. Total synthesis of twenty-five picrotoxanes by virtual library selection

231. Author Correction: π-HuB: the proteomic navigator of the human body

232. Digital origins for ancient digits

233. Daily briefing: Explore 2024 with Leif Penguinson

234. Build your own receptor: modular system can be tailored to any antigen

235. That Christmas jumper is a marvel of complicated physics

236. Behind the scenes of Nature News & Views in 2024

237. Can novelty scores on papers shift the power dynamics in scientific publishing?

238. Is political interference causing faculty brain drain in the southern United States?

239. I create routes through trees to help stop howler monkeys being electrocuted by power lines

240. Stem cells head to the clinic: treatments for cancer, diabetes and Parkinson’s disease could soon be here

241. Daily briefing: Climate scientists determined to rise to the challenge of Trump 2.0

242. A reinforced lunar dynamo recorded by Chang''e-6 farside basalt

243. Signatures of ambient pressure superconductivity in thin film La3Ni2O7

244. Skin in the game — locally made antibodies fight resident bacteria

245. A blood test detects aged cells

246. Daily briefing: Infamous ‘hydroxychloroquine for COVID-19’ paper has been retracted

247. Are you what you eat? How food shapes self-image

248. Inside an Argentinian nuclear reactor, science and politics collide

249. How to find your place in science through an industry postdoc

250. How to beat the biases harming women’s mental health

251. Humans evolved for distance running – but ancestor ‘Lucy’ didn’t go far or fast

252. Humanity’s noise is the natural world’s enemy

253. Dread and determination: how climate scientists are preparing for Trump 2.0

254. How Los Angeles neighbours partnered to show under-represented students the ‘unspoken rules’ to success

255. What were some of the biggest stories of 2024? Join us for the Nature Podcast quiz!

256. Why eating less slows ageing: this molecule is key

257. The Nature Podcast festive spectacular 2024

258. Atmospheric rivers lead to heat extremes

259. Algae use the underwater light spectrum to sense depth

260. A bile acid could explain how calorie restriction slows ageing

261. Simultaneous phase transition and chemical reaction in a heat-storing material

262. Sea ice is shrinking during Antarctic winter: here’s what it means for Earth’s oceans and atmosphere

263. Vapour-deposited thin films raise the possibility of portable nuclear clocks

264. Machine learning helps to determine the diverse conformations of RNA molecules

265. A dormant overmassive black hole in the early Universe

266. Four-component protein nanocages designed by programmed symmetry breaking

267. Growth-based monolithic 3D integration of single-crystal 2D semiconductors

268. Record-low Antarctic sea ice in 2023 increased ocean heat loss and storms

269. Tidally driven remelting around 4.35 billion years ago indicates the Moon is old

270. Synaptic basis of feature selectivity in hippocampal neurons

271. Determining structures of RNA conformers using AFM and deep neural networks

272. Atmospheric rivers cause warm winters and extreme heat events

273. Engineered extrachromosomal oncogene amplifications promote tumorigenesis

274. Timely TGFβ signalling inhibition induces notochord

275. Hierarchical design of pseudosymmetric protein nanocages

276. Terahertz field-induced metastable magnetization near criticality in FePS3

277. Spatial transcriptomic clocks reveal cell proximity effects in brain ageing

278. Diatom phytochromes integrate the underwater light spectrum to sense depth

279. Trimodal thermal energy storage material for renewable energy applications

280. 229ThF4 thin films for solid-state nuclear clocks

281. The conformational space of RNase P RNA in solution

282. Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

283. Lithocholic acid phenocopies anti-ageing effects of calorie restriction

284. Nucleosome fibre topology guides transcription factor binding to enhancers

285. Scalable production of ultraflat and ultraflexible diamond membrane

286. Ancient genomes reveal a deep history of treponemal disease in the Americas

287. This digital-memory device keeps its cool even at 600 C

288. Give ‘science for peace’ a chance

289. The small-drone revolution is coming — scientists need to ensure it will be safe

290. In the space between the seconds

291. How car and battery companies can work around US trade tariffs and rules

292. Controversial COVID study that promoted unproven treatment retracted after four-year saga

293. Moral conundrums and more: Books in brief

294. Daily briefing: How synthetic ‘mirror life’ bacteria could infect the world

295. Giant study finds untrustworthy trials pollute gold-standard medical reviews

296. Pioneering journal eLife faces major test after loss of impact factor

297. Why I’m challenging Brazil’s gender norms for my daughter

298. Good COPs, bad COPs: science struggles in a year of environmental summits

299. Animals in sticky situations

300. To spur climate action, educators must get personal