1. This compound enhances long-term memory of mice — but only in females

2. Scientists face fallout for past associations with Epstein

3. How an exercise-activated enzyme helps to keep the brain young

4. CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly

5. Brains of ‘super agers’ are still strong producers of new neurons

6. Lipid nanoparticles engineered to target therapeutic RNA to the pancreas

7. Sea-urchin spines generate electrical signals in flowing water

8. Light-confining device can control superconductivity — even in the dark

9. Protein engineering fixes a major crop trade-off

10. Amplified X-ray laser pulses achieved using mirror set-up

11. The secret of squeaky basketball shoes

12. Parkinson’s disease affects network of brain regions that controls whole-body action

13. Environmental exposure trains the immune system to dampen allergic responses

14. Flexible paths to multicellularity

15. The protein carriers of hundreds of lipids have been identified

16. We need a global assessment of avoidable climate-change risks

17. Stem cells provide a potent treatment for frailty

18. Entanglement-assisted non-local optical interferometry in a quantum network

19. Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease

20. Uncovering origins of heterogeneous superconductivity in La3Ni2O7

21. Functional dissection of complex trait variants at single-nucleotide resolution

22. CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis

23. Coral microbiomes as reservoirs of unknown genomic and biosynthetic diversity

24. Argentine fossil rewrites evolutionary history of a baffling dinosaur clade

25. Hydrofluorocarbon electrolytes for energy-dense and low-temperature batteries

26. Field-free full switching of chiral antiferromagnetic order

27. Rewiring an E3 ligase enhances cold resilience and phosphate use in maize

28. A disease model resource reveals core principles of tissue-specific cancer evolution

29. OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours

30. Convergent MurJ flippase inhibition by phage lysis proteins

31. Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate

32. Pivoting colloidal assemblies exhibit mechanical metamaterial behaviour

33. Squeaking at soft–rigid frictional interfaces

34. Pancreatic-targeted lipid nanoparticles based on organ capsule filtration

35. Peripheral immune-inducer dendritic cells drive early-life allergic inflammation

36. Vectorized instructive signals in cortical dendrites

37. A membrane-bound nuclease directly cleaves phage DNA during genome injection

38. Echinoderm stereom gradient structures enable mechanoelectrical perception

39. Compact deep neural network models of the visual cortex

40. Cavity-altered superconductivity

41. Limitations of probing field-induced response with STM

42. How earthquakes and lightning help explain squeaky sneakers

43. The surprising science of squeaky sneakers

44. Reply to: Limitations of probing field-induced response with STM

45. What''s the best way to change research fields? These three scientists have ideas

46. The future perfect continuous passive and other transitive disorders of the mind

47. EU leaders should not rush to revamp green-hydrogen rules

48. Five ways to spot when a paper is a fraud

49. Daily briefing: COVID’s origins — what we do and don’t know

50. The first ice-core record of historical atmospheric hydrogen levels

51. The age of animal experiments is waning. Where will science go next?

52. Pop-up journals for policy research: can temporary titles deliver answers?

53. This ant species is composed of only queens — no workers or males

54. Sewage systems secretly waft pollution into the air

55. Dynamic antigen expression and cytotoxic T cell resistance in HIV reservoir clones

56. Editorial Expression of Concern: Opposing roles for calcineurin and ATF3 in squamous skin cancer

57. Nuclear weapons testing is harmful — there’s no case for a restart

58. Treasures of scientific history could be hiding in plain sight

59. Author Correction: Global subsidence of river deltas

60. Scientists must step up to avert a nuclear breakout

61. Daily briefing: New AI drug-discovery engine is ‘on the scale of an AlphaFold4’

62. Daily briefing: ‘Universal’ vaccine protects mice from multiple pathogens

63. COVID’s origins: what we do and don’t know

64. China is waging war on Alzheimer’s. What can its approach teach the rest of the world?

65. Evidence alone won’t save biodiversity: the golden apple snail reveals an implementation gap

66. Account for AI in the environmental footprint of scientific publishing

67. Defunding Chile’s climate research will undermine science and the region

68. The Contributor Role Taxonomy tool must serve to record extent of authorship

69. Whistle while you whinny: researchers identify two sounds straight from the horse’s mouth

70. Iron Age mass grave reveals unprecedented violence against women and children

71. First-of-a-kind stem cell therapies set for approval in Japan

72. Markovnikov hydroamination of terminal alkenes via phosphine redox catalysis

73. How big is the ‘motherhood penalty’? In Denmark, it adds up to 120,000

74. Why every scientist needs a librarian

75. Music is not a universal language — but it can bring us together when words fail

76. This AI can improve your peer review — and make it more polite

77. Historically Black US universities chase top research ranking

78. AI tools can design genomes. Will they upend how life evolves?

79. From Victorian voyages to vanishing maps: Books in brief

80. Gel helps mini spinal cords to heal from injury

81. Why do curling stones slide across ice the way they do?

82. Are obesity drugs causing a severe complication? What the science says

83. AI is threatening science jobs. Which ones are most at risk?

84. Runaway black hole leaves a trail of stars

85. Briefing chat: How hovering bumblebees keep their cool

86. Author Correction: Natural behaviour is learned through dopamine-mediated reinforcement

87. Publisher Correction: PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling

88. Daily briefing: Automated robot ‘scientists’ spark debate over the future of lab work

89. Five ways increased militarization could change scientific careers

90. Daily briefing: What we know about autism and ageing — and what we don’t

91. Super-sticky feet help a robot to climb the walls

92. ‘Universal vaccine’ protects mice against multiple pathogens

93. Biotech investor set to lead US National Science Foundation

94. Blood test holds promise for predicting when Alzheimer’s symptoms will start

95. Host control of persistent Epstein–Barr virus infection

96. Science journalism on the ropes worldwide as US aid cuts bite

97. Academia’s parent trap: the struggles faced by researcher mothers

98. ‘An AlphaFold 4’ – scientists marvel at DeepMind drug spin-off’s exclusive new AI

99. This giant virus hijacks cells’ protein-making machinery to multiply wildly

100. Forest soils are running short of nutrients as CO2 emissions rise

101. Gene editing treats a mouse model of a neurodevelopmental disorder

102. Oysters build reefs with optimal geometries

103. Malaria is hindered by repression of a cell-cycle protein

104. Laser-written glass tablets can preserve data for millennia

105. Chip-scale device efficiently boosts light signals

106. AI succeeds in diagnosing rare diseases

107. Personalized mRNA vaccine induces strong, durable immunity in hard-to-treat breast cancer

108. Turning on the ‘for you’ feed on X shifted political opinions, but turning it off did not

109. AI offers way to image and assess clinical cell samples

110. Microsoft team creates ''revolutionary'' data storage system that lasts for millennia

111. How ‘skull drains’ keep the brain safe from damage and pathogens

112. The integrated stress response promotes immune evasion through lipocalin 2

113. Cold-injection synthesis of highly emissive perovskite nanocrystals

114. Higher-dimensional Fermiology in bulk moiré metals

115. Ancestry and somatic profile indicate acral melanoma origin and prognosis

116. Mucosal vaccination clears Clostridioides difficile colonization

117. An agentic system for rare disease diagnosis with traceable reasoning

118. The political effects of X’s feed algorithm

119. Integrase anchors viral RNA to the HIV-1 capsid interior

120. Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor

121. Agouti integrates environmental cues to regulate paternal behaviour

122. Ancient co-option of LTR retrotransposons as yeast centromeres

123. Nucleotide signals coordinate activation and inhibition of bacterial immunity

124. A roadmap for evaluating moral competence in large language models

125. Clinical-grade autonomous cytopathology through whole-slide edge tomography

126. Integrated photonics enabling ultra-wideband fibre–wireless communication

127. Laser writing in glass for dense, fast and efficient archival data storage

128. Highly dynamic dural sinuses support meningeal immunity

129. RYK is a GPNMB receptor that drives MASH

130. In vivo base editing of Chd3 rescues behavioural abnormalities in mice

131. Roles of microtubules and LIS1 in dynein transport machinery assembly

132. Single-cell and isoform-specific translational profiling of the mouse brain

133. Reduced cyclin D3 expression in erythroid cells protects against malaria

134. Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC

135. Practical lithium–organic batteries enabled by an n-type conducting polymer

136. Accurate predictions of disordered protein ensembles with STARLING

137. The natural architecture of oyster reefs maximizes recruit survival

138. Rising atmospheric CO2 reduces nitrogen availability in boreal forests

139. Giant energy storage and dielectric performance in all-polymer nanocomposites

140. This chunk of glass could store two million books for 10,000 years

141. Stereospecific alkyl–alkyl cross-coupling of boronic esters

142. Deepest-ever rock core extracted from under Antarctic ice sheet

143. Mid-cycle update

144. Author Correction: BCL6 enables Ph acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition

145. Will self-driving ''robot labs'' replace biologists? Paper sparks debate

146. Daily briefing: The science influencers tackling misinformation online

147. Why China and Europe should collaborate to ‘defossilize’ the world’s carbon

148. How do autistic people age — and what does it mean for their health?

149. A Yangtze without fishers — but not without fish

150. Nanoscience is latest discipline to embrace large-scale replication efforts

151. Don’t deprioritize curiosity-driven research

152. Student dilemma: physical science or physical education?

153. Updates to the ‘bible’ for mental-health conditions will miss the mark — is it time to ditch the DSM?

154. Publisher Correction: Psychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling

155. The science influencers going viral on TikTok to fight misinformation

156. Brain differences between sexes get more pronounced from puberty

157. Why sky-high pay for AI researchers is bad for the future of science

158. What’s behind ‘teensplaining’? Scientists should study this adolescent behaviour

159. The funding system needs fixing — but it’s not a ‘waste of time and money’

160. Statistical approximation is not general intelligence

161. Smartphones are a double-edged tool in classrooms

162. Daily briefing: New platform lets AI agents hire human helpers in the ‘meatspace’

163. De novo design of GPCR exoframe modulators

164. Editorial Expression of Concern: Deacetylation of p53 modulates its effect on cell growth and apoptosis

165. Editorial Expression of Concern: Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

166. Author Correction: The genomic landscape of response to EGFR blockade in colorectal cancer

167. ‘What are we doing here?’ The polymaths who searched for the meaning of life

168. How to wow a popular-science writer with your research expertise

169. Daily briefing: Exercise rewires the brain for endurance, in mice

170. Can consciousness ever be understood — this side of death?

171. Why Europe barred China from flagship Horizon research programmes

172. Why we don’t really know what the public thinks about science

173. CAR-T therapy provides relief for children with autoimmune diseases

174. Exclusive: Key US infectious-diseases centre to drop pandemic preparation

175. When a colleague dies: exploring academia''s ‘death-denying’ culture

176. AI agents are hiring human ''meatspace workers'' — including some scientists

177. How AI slop is causing a crisis in computer science

178. Daily briefing: The centre of our Galaxy might not be a black hole

179. ‘I was nearly arrested’: escaping Myanmar’s military leadership for a PhD abroad

180. Parasitic wasps use tamed virus to castrate caterpillars

181. Briefing Chat: Caffeine slows brain ageing, suggests decades of data

182. Daily briefing: Hunter-gatherers in Europe’s ‘water world’ resisted the switch to farming for millennia

183. Is social media addictive for teens? US courts wade into scientific debate

184. US repeals key ‘endangerment finding’ that climate change is a public threat

185. How some COVID vaccines triggered rare blood-clot disorder

186. AI help in grant proposals tied to higher funding odds at NIH

187. Publisher Correction: Physiology and immunology of a pig-to-human decedent kidney xenotransplant

188. Exercise rewires the brain — boosting the body’s endurance

189. The ‘astounding’ rise of semaglutide — and what’s next for weight-loss drugs

190. Flexible joints: robot morphs into a range of cyborg species

191. From ancient temples to bomb craters: explore Laos’s layered history — in photos

192. Self-powered vibration sensor for wearable health care and voice detection

193. Science funding needs fixing — but not through chaotic reforms

194. China to punish universities that fail to sanction research misconduct

195. Trump team’s new rule could make firing government scientists easier

196. My ‘detective’ job as a competitive-intelligence consultant for pharma

197. Author Correction: Inference and reconstruction of the heimdallarchaeial ancestry of eukaryotes

198. Four ways I ensured my research brought about real-world change

199. Clearing trapped cholesterol could relieve lymphoedema

200. Charge-neutral electrons are odd — except when they’re even

201. Squirrels could be a reservoir for the virus that causes mpox

202. Support people and their livelihoods rather than fossil-fuel industries

203. Immune cells could be protected from ‘exhaustion’ by flipping genetic switches

204. Ten years since the first reported observation of gravitational waves

205. Robust partitioning of cell contents by physical instabilities and biological clocks

206. Can the clean-energy revolution save us from climate catastrophe?

207. Hunter-gatherers took refuge in European ''water world'' for millennia

208. Babies at nursery shape each other’s microbiomes

209. Untapped catalytic ability of aluminium has been unlocked

210. Large-scale quantum communication networks with integrated photonics

211. Sub-part-per-trillion test of the Standard Model with atomic hydrogen

212. Sleep-dependent clearance of brain lipids by peripheral blood cells

213. Single-shot parity readout of a minimal Kitaev chain

214. Parity-doublet coherence times in optically trapped polyatomic molecules

215. Sub-second volumetric 3D printing by synthesis of holographic light fields

216. Striatum-wide dopamine encodes trajectory errors separated from value

217. Continuous-wave narrow-linewidth vacuum ultraviolet laser source

218. Lasting Lower Rhine–Meuse forager ancestry shaped Bell Beaker expansion

219. Giant magnetocaloric effect and spin supersolid in a metallic dipolar magnet

220. Targeting excessive cholesterol deposition alleviates secondary lymphoedema

221. SLAMF6 as a drug-targetable suppressor of T cell immunity against cancer

222. Months-long stability of the head-direction system

223. Astrocytes enable amygdala neural representations supporting memory

224. Fossil isotope evidence for trophic simplification on modern Caribbean reefs

225. Pre-incision structures reveal principles of DNA nucleotide excision repair

226. Conformational diversity and fully opening mechanism of native NMDA receptor

227. Maximizing perovskite electroluminescence with ordered 3D/2D heterojunction

228. Transmission of MPXV from fire-footed rope squirrels to sooty mangabeys

229. CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome

230. Aluminium redox catalysis enables cyclotrimerization of alkynes

231. Tiny robot fish could swim through the body powered by ultrasound

232. An ancient Roman game board’s secrets are revealed — with AI’s help

233. These hungry immune cells tidy sleeping flies'' brains

234. Transferable enantioselectivity models from sparse data

235. African countries must take control of health policy

236. Daily briefing: Caffeine might reduce dementia risk and slow cognitive decline

237. 18,000,000 minutes

238. What drugs are safe during pregnancy? There’s a shocking lack of data

239. My professor said ‘Black people are not interested in the environment’. I set out to prove him wrong

240. What can I do if my idea has been plagiarized?

241. Tree rings and salt lakes give clues about ancient rainfall

242. How to rescue the aid industry: focus on conflict prevention, not just relief

243. Lab morale got you down? Try a handbook

244. Dozens of researchers will move to France from US following high-profile bid to lure talent

245. Public-speaking tips from the experts: what scientists can learn from comics, musicians and actors

246. China’s biotech boom: why the nation must collaborate to stay ahead

247. Marine protection in the Azores: a triumph for conservation and sustainability

248. Publishing less won’t save the research system

249. Preserving water under megacities is crucial — and urgent

250. Internet blackout: Iran’s academic shutdown

251. Coffee drinking linked to slower brain ageing

252. Daily briefing: The dark side of the battery boom

253. Daily briefing: Bonobo’s tea party is first demonstration of pretend play in a non-human

254. My mission to make life more user friendly for the disability community

255. Jupiter gets downsized — and squashed

256. How to stop the survey-taking AI chatbots that threaten to upend social science

257. The dark side of green technology: what do electric vehicles really cost?

258. Measles is raging worldwide: are you at risk?

259. Super-sniffer aeroplane finds oil fields’ hidden emissions

260. US grant applicants surge at prestigious European research agency

261. Epstein files reveal deeper ties to scientists than previously known

262. Cheap AI chatbots transform medical diagnoses in places with limited care

263. Author Correction: Environmentally driven immune imprinting protects against allergy

264. Briefing Chat: ''External lungs'' keep man alive for 48 hours until transplant

265. OpenClaw AI chatbots are running amok — these scientists are listening in

266. Daily briefing: Tumours use neurons as hotline to the brain

267. ‘We need to dismantle the stigma of alcohol dependence in academia’

268. Universities in exile: displaced scholars count the costs of starting afresh

269. Not just a chip off the old block: nanoparticles reveal odd traits

270. This bonobo had a pretend tea party — showing make believe isn’t just for humans

271. Beetle is locked in to an eternal dance ― with an ant

272. Publisher Correction: Colibactin-driven colon cancer requires adhesin-mediated epithelial binding

273. Is UK science in jeopardy? Huge funding reforms spark chaos and anxiety

274. Author Correction: PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

275. NASA’s latest telescope is a feat of early-career leadership

276. First ‘practical PhDs’ awarded in China — for products rather than papers

277. These mysterious ridges could be the secret to younger skin

278. Daily briefing: More than one-third of cancer cases are preventable

279. Innovative CAR-T therapy destroys cancer cells without dangerous side effects

280. How a protein repurposes vitamin B12 as a light sensor

281. A way to gauge the equity of ocean-related initiatives

282. Immune cells from the gut drive development of Parkinson’s disease in the brain

283. Evolutionary insights into a skin fold

284. Atlantic ocean currents defied the ice age

285. How tumours trick the brain into shutting down cancer-fighting cells

286. Particle collisions cast light on how matter forms from seemingly empty space

287. Open-source AI tool beats giant LLMs in literature reviews — and gets citations right

288. Common genetic variants affect risk of a major cause of pregnancy loss

289. A tumour-to-brain pathway hinders anticancer defences

290. Machine learning slashes the testing needed to work out battery lifetimes

291. Chemical capture of diazo metabolites reveals biosynthetic hydrazone oxidation

292. Measuring spin correlation between quarks during QCD confinement

293. Efficient near-telomere-to-telomere assembly of nanopore simplex reads

294. Integrated structural dynamics uncover a new B12 photoreceptor activation mode

295. Mosquito–capsid interactions contribute to flavivirus vector specificity

296. Rete ridges form via evolutionarily distinct mechanisms in mammalian skin

297. Activated ATF6α is a hepatic tumour driver restricting immunosurveillance

298. Resolving intervalley gaps and many-body resonances in moiré superconductors

299. Cleavage of mRNAs by a minority of pachytene piRNAs improves sperm fitness

300. Regulation of STING activation by phosphoinositide and cholesterol