1. This malaria vaccine is delivered by a mosquito bite

2. Why a teenager’s bird-flu infection is ringing alarm bells for scientists

3. Farmers’ fires leave long-lasting smudge on African weather

4. Brain-penetrating molecule might offer a route to treat glioblastoma tumours

5. Evolutionary innovation hints at ways to engineer efficient photosynthesis in crops

6. Squid-inspired pills squirt drugs straight into your gut

7. ‘Forever’ chemicals can be destroyed with clever chemistry — now test these techniques outside the lab

8. Catalysts degrade forever chemicals with visible light

9. Newborn planet found in a warped system

10. Squid-inspired jet devices deliver drugs without a need for needles

11. Human antibodies offer broad inhibition against variable proteins of the malaria parasite

12. Computational technologies of the Human Cell Atlas

13. Cellular atlases are unlocking the mysteries of the human body

14. How a fly’s behavioural state affects its view of the world

15. Your friends shape your microbiome — and so do their friends

16. Quantum computing: physics–AI collaboration quashes quantum errors

17. When is a soil too dry for plants to take up water?

18. AI’s computing gap: academics lack access to powerful chips needed for research

19. Common genetic variants contribute more to rare diseases than previously thought

20. A ‘Wikipedia for cells’: researchers get an updated look at the Human Cell Atlas, and it’s remarkable

21. Revised historical record sharpens perspective on global warming

22. Combining quantum processors with real-time classical communication

23. Mineralized collagen plywood contributes to bone autograft performance

24. Social state alters vision using three circuit mechanisms in Drosophila

25. A giant planet transiting a 3-Myr protostar with a misaligned disk

26. Gut microbiome strain-sharing within isolated village social networks

27. Single-cell integration reveals metaplasia in inflammatory gut diseases

28. Human HDAC6 senses valine abundancy to regulate DNA damage

29. Local probe of bulk and edge states in a fractional Chern insulator

30. Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma

31. An integrated transcriptomic cell atlas of human neural organoids

32. A multi-omic atlas of human embryonic skeletal development

33. Examining the role of common variants in rare neurodevelopmental conditions

34. A functional microbiome catalogue crowdsourced from North American rivers

35. Nonlinear receptive fields evoke redundant retinal coding of natural scenes

36. Direct magnetic imaging of fractional Chern insulators in twisted MoTe2

37. Cephalopod-inspired jetting devices for gastrointestinal drug delivery

38. Single-molecule states link transcription factor binding to gene expression

39. Learning high-accuracy error decoding for quantum processors

40. Liver X receptor unlinks intestinal regeneration and tumorigenesis

41. Trion sensing of a zero-field composite Fermi liquid

42. Spatially restricted immune and microbiota-driven adaptation of the gut

43. Early-twentieth-century cold bias in ocean surface temperature observations

44. Normal breast tissues harbour rare populations of aneuploid epithelial cells

45. Fibular reduction and the evolution of theropod locomotion

46. Exaptation of ancestral cell-identity networks enables C4 photosynthesis

47. Efficient green InP-based QD-LED by controlling electron injection and leakage

48. A spatial human thymus cell atlas mapped to a continuous tissue axis

49. Broadly inhibitory antibodies to severe malaria virulence proteins

50. Genetic defects of brain immunity in childhood herpes simplex encephalitis

51. Reply to: Concerns regarding proposed groundwater Earth system boundary

52. Photocatalytic low-temperature defluorination of PFASs

53. Coupling of unactivated alkyl electrophiles using frustrated ion pairs

54. Concerns regarding proposed groundwater Earth system boundary

55. The Human Cell Atlas from a cell census to a unified foundation model

56. Photocatalytic C–F bond activation in small molecules and polyfluoroalkyl substances

57. A cell atlas foundation model for scalable search of similar human cells

58. Daily briefing: The fun of winning science’s satirical Ig Nobel prize

59. Leading Nature Index science cities in physical sciences: regional centres drive China’s progress

60. Leading Nature Index science cities in Earth and environmental science: Research output gathers pace in China

61. How ‘Made in China 2025’ helped supercharge scientific development in China’s cities

62. Boston’s dense health-sciences networks help the city to maintain its lead

63. Leading Nature Index science cities in chemistry: China positions for clean sweep

64. How being multilingual both helps and hinders me and my science

65. Leading Nature Index science cities in biological sciences: collaboration powers US research

66. Leading Nature Index science cities in health sciences: US institutions power country’s growth

67. China’s regional cities are now major players in world science

68. Half of the top 20 science cities are now in China — and regional city growth is the key

69. I’ll burn this bridge when you get here

70. Ferocity of Atlantic hurricanes surges as the ocean warms

71. Should I climb the career ladder as a manager, or will I regret leaving the lab bench behind?

72. How students and grandparents could solve the global mental-health crisis

73. Superconductivity researcher who committed misconduct exits university

74. Leon Cooper obituary: Nobel laureate who developed theory of superconductivity

75. Setting the stage for using AI in language tasks 50 years ago

76. How the world will weather Trump’s withdrawal from global agreements

77. How a silly science prize changed my career

78. Can Google Scholar survive the AI revolution?

79. Daily briefing: NIH braces for reform as Trump administration closes in

80. Health of people who are displaced in their own countries is a neglected global crisis

81. Words won’t reduce the impact of conflict on nature — what’s needed is action

82. Nobel-prizewinning economics research says don’t dismantle DEI initiatives

83. Communicate the risk as well as the promise of weight-loss drugs

84. ‘Heroic interference’ should not be the endgame of coral-reef restoration

85. Does South Korea have what it takes to become a leading space nation?

86. First rocks returned from Moon’s far side reveal ancient volcanic activity

87. Fat cells have a ‘memory’ of obesity — hinting at why it’s hard to keep weight off

88. Adipose tissue retains an epigenetic memory of obesity after weight loss

89. Geological Net Zero and the need for disaggregated accounting for carbon sinks

90. What a forest’s glow can reveal about the impact of environmental change

91. Is it really a sin if it’s hardwired in? The neurological basis for ‘bad’ behaviour

92. Killer questions at science job interviews and how to ace them

93. Daily briefing: Tech giants invest in next-generation geothermal energy

94. Why we need a body to oversee how science is used by governments

95. Publisher Correction: Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei

96. How human brains got so big: our cells learned to handle the stress that comes with size

97. Major biomedical funder NIH poised for massive reform under Trump 2.0

98. Radiation for dummies: the female mannequins testing space-travel safety

99. Daily briefing: Big tomatoes get sweeter thanks to CRISPR editing

100. Fragments of eternal youth

101. Lunar farside volcanism 2.8 billion years ago from Chang’e-6 basalts

102. How stress can disrupt memory and lead to anxiety

103. Resistance to crucial malaria drug detected in severely ill kids in Africa

104. Geothermal power is vying to be a major player in the world’s clean-energy future

105. Engineered receptors for soluble cellular communication and disease sensing

106. Trust in scientists starts to recover in the United States at last — but barely

107. Can robotic lab assistants speed up your work?

108. Huge carnivorous ‘terror bird’ rivalled the giant panda in size

109. Daily briefing: An elephant learns to shower — until her jealous rival turns to sabotage

110. Why AI-generated recommendation letters sell applicants short

111. Why it’s in rich nations’ interests to fund climate finance

112. Google uses millions of phones to map Earth’s ionosphere and improve GPS

113. Reducing pregnancy risk could be as easy as chewing gum

114. CRISPR builds a big tomato that’s actually sweet

115. Bone marrow in the skull plays a surprisingly important role in ageing

116. Dental evidence for extended growth in early Homo from Dmanisi

117. NK2R control of energy expenditure and feeding to treat metabolic diseases

118. Keeping the global consumption within the planetary boundaries

119. Adult skull bone marrow is an expanding and resilient haematopoietic reservoir

120. Structural variation in the pangenome of wild and domesticated barley

121. Migrating is not enough for modern planktonic foraminifera in a changing ocean

122. Past foraminiferal acclimatization capacity is limited during future warming

123. Entanglement and iSWAP gate between molecular qubits

124. A combinatorial neural code for long-term motor memory

125. Biodiversity impacts of the 2019–2020 Australian megafires

126. Releasing a sugar brake generates sweeter tomato without yield penalty

127. Intravenous and intracranial GD2-CAR T cells for H3K27M diffuse midline gliomas

128. Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1

129. Observation of Hilbert space fragmentation and fractonic excitations in 2D

130. Prefrontal transthalamic uncertainty processing drives flexible switching

131. Foundation models for fast, label-free detection of glioma infiltration

132. Clinical functional proteomics of intercellular signalling in pancreatic cancer

133. Photochemical permutation of thiazoles, isothiazoles and other azoles

134. Australian megafires drove complex biodiversity outcomes

135. Iron levels unexpectedly limit bacterial growth in the ocean’s twilight zone

136. Robotic exoskeleton adapts to changes in leg movements in real time

137. Fossilized bird skull from 80 million years ago clarifies early avian evolution

138. Two for one: candidate obesity drug boosts energy use and curbs calorie intake

139. Tomato engineering hits the sweet spot to make big sugar-rich fruit

140. Errors in cell division stopped by an atypical cyclin-dependent kinase

141. Are rising carbon dioxide and nitrogen deposition a joint threat to biodiversity globally?

142. Space weather mapped by millions of smartphones

143. What happens when a bacterium gets into a fungus and stays — for generations

144. Growing up slowed down for an early Homo individual

145. High-temperature 205Tl decay clarifies 205Pb dating in early Solar System

146. Accelerated formation of ultra-massive galaxies in the first billion years 

147. Charge-neutral electronic excitations in quantum insulators

148. Mapping the ionosphere with millions of phones

149. Task-agnostic exoskeleton control via biological joint moment estimation

150. Fluorspar to fluorochemicals upon low-temperature activation in water

151. Thixotropic world

152. Daily briefing: AlphaFold3 is now open source

153. How AI is reshaping science and society

154. Postdocs count the cost of living in Ireland’s capital

155. Can AI review the scientific literature — and figure out what it all means?

156. Ice-giant planet was having a bad day when Voyager came calling

157. Rice is not as nice with global warming

158. Author Correction: Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

159. To boost science, the growing BRICS group must embrace inclusion and transparency

160. ‘I get paid for my outputs, not because I am Māori’: why Indigenous researchers often face double duty

161. Growth area: early studies exploring how tissues and cells grow

162. South Korea can boost the research potential of low-income countries

163. Why did Earth’s first radio message to alien civilizations leave out half of humanity?

164. Why we are all lab rats in the digital world

165. The quest to build bionic limbs that feel like the real thing

166. Daily briefing: There is a multitude of microbe-based climate solutions — time to use them

167. Global warming is on the cusp of crucial 1.5 C threshold, suggest ice-core data

168. The next massive volcano eruption will cause climate chaos — and we are unprepared

169. Worryingly high prevalence of retraction among top-cited researchers

170. Devastating Spanish floods expose an urgent need for more flood-risk professionals

171. Ignoring journal metrics on CVs is an act of privilege

172. Systemic biases are leading to an intersex research void

173. Your dissertation is your business card!

174. Trump’s shadow looms at climate summit: what COP29 could deliver

175. Dining with dinosaurs and more: Books in brief

176. 8 million cells: virtual embryo shows organs forming in exquisite detail

177. AI protein-prediction tool AlphaFold3 is now open source

178. How I’m turning seaweed into biofuel for cars on Barbados

179. Two places at once: superposed crystal could test whether gravity obeys quantum laws

180. Circular logic: understanding RNA’s strangest form yet

181. Author Correction: Testing quantum electrodynamics in extreme fields using helium-like uranium

182. Daily briefing: First DNA from Pompeii body casts illuminates who victims were

183. Cosmic connections: our changing vision of the heavens

184. Grass-roots grant-writing approaches can help researchers at small institutions to succeed

185. Should Alzheimer’s be diagnosed without symptoms? Proposal to rely on blood tests roils scientists

186. Emissions from private jets are soaring

187. This scientist treated her own cancer with viruses she grew in the lab

188. No hearing aids needed: bats’ ears stay keen well into old age

189. Grass-roots pressure grows to boost support for breastfeeding scientists

190. ‘Rapture and beauty’: a writer’s portrait of the International Space Station

191. In that land

192. Daily briefing: World’s first wooden satellite heads for space

193. World-first stem-cell treatment restores vision in people

194. What Trump’s election victory could mean for AI, climate and more

195. Will South Africa become first country to accept controversial form of human genome editing?

196. Why do wet dogs shake themselves dry? Neuroscience has an answer

197. First DNA from Pompeii body casts illuminates who victims were

198. New CERN chief pledges to forge ahead with 17-billion supercollider

199. Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

200. Author Correction: Three-dimensional wave breaking

201. Daily briefing: Heart attacks trigger deep healing sleep

202. How understudied endometriosis causes pain for hundreds of millions of women

203. Trump’s US election win: researchers must stay strong and united

204. ‘Anyone engaging in scientific practice shouldn’t be excluded’: The United Kingdom’s only Black chemistry professor, on diversity

205. Don’t blame search engines for sending users to unreliable sites

206. Division of labour: mitochondria split to meet energy demands

207. Smashing atomic nuclei together reveals their elusive shapes

208. Rare snapshots of a kiwi-shaped atomic nucleus

209. Fat keeps metabolism in tune and on time using an inflammatory immune protein

210. ‘We need to be ready for a new world’: scientists globally react to Trump election

211. Clues to the origin of embryonic development in animals

212. Mysterious radio bursts mostly come from massive galaxies

213. Surprise finding reveals mitochondrial ‘energy factories’ come in two different types

214. Sticky situation: how adhesive bacteria drive colon cancer

215. Colibactin-driven colon cancer requires adhesin-mediated epithelial binding

216. Origins and impact of extrachromosomal DNA

217. Enhancing transcription–replication conflict targets ecDNA-positive cancers

218. Electrically driven long-range solid-state amorphization in ferroic In2Se3

219. Learning-associated astrocyte ensembles regulate memory recall

220. India–Eurasia convergence speed-up by passive-margin sediment subduction

221. Offline ensemble co-reactivation links memories across days

222. Observation of vortices in a dipolar supersolid

223. A broadband hyperspectral image sensor with high spatio-temporal resolution

224. Postsynaptic competition between calcineurin and PKA regulates mammalian sleep–wake cycles

225. Imaging shapes of atomic nuclei in high-energy nuclear collisions

226. Intermittent rate coding and cue-specific ensembles support working memory

227. Cellular ATP demand creates metabolically distinct subpopulations of mitochondria

228. Ab initio characterization of protein molecular dynamics with AI2BMD

229. Bioelastic state recovery for haptic sensory substitution

230. Layered hybrid superlattices as designable quantum solids

231. Automated real-world data integration improves cancer outcome prediction

232. Central pattern generator control of a vertebrate ultradian sleep rhythm

233. A multicellular developmental program in a close animal relative

234. A mechanism for hypoxia-induced inflammatory cell death in cancer

235. Stochastic neuropeptide signals compete to calibrate the rate of satiation

236. Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation

237. Nucleosome flipping drives kinetic proofreading and processivity by SWR1

238. Identification and genetic dissection of convergent persister cell states

239. Immune responses in checkpoint myocarditis across heart, blood and tumour

240. A cellular basis for mapping behavioural structure

241. Preferential occurrence of fast radio bursts in massive star-forming galaxies

242. Autonomous mobile robots for exploratory synthetic chemistry

243. Selective ion transport through hydrated micropores in polymer membranes

244. Coordinated inheritance of extrachromosomal DNAs in cancer cells

245. A new kind of mitochondrion

246. Blood test could help diagnose bipolar disorder — but some researchers are sceptical

247. Eyes in the sky usher in new era of law and order

248. Tracking methane super-emitters from space

249. All we are is our memories

250. Science communication will benefit from research integrity standards

251. Citizen scientists can be chemists — give them a chance

252. The antibodies don’t work! The race to rid labs of molecules that ruin experiments

253. Creating new materials by turning failure on its head

254. Author Correction: Differentiation fate of a stem-like CD4 T cell controls immunity to cancer

255. Daily briefing: The man sniffing out fraudsters that sell fake degrees

256. Mechanistic understanding and efficient engineering of crystal phases in 2D materials

257. Cat brains age like ours — and could help scientists to understand cognitive decline

258. How to climate-proof crops: scientists say the secret’s in the dirt

259. China’s thriving forests are stockpiling vast amounts of carbon

260. From the archive: election special

261. COP29: involve the IPCC in defining climate finance

262. A spider’s windproof web

263. Is there a ‘Goldilocks zone’ for paper length?

264. ChatGPT is transforming peer review — how can we use it responsibly?

265. AI-generated images threaten science — here’s how researchers hope to spot them

266. How ‘miracle’ weight-loss drugs will change the world

267. India’s US20-billion fertilizer subsidies could do more for farmers — here’s how

268. ‘Invisible and uncharismatic’ fungi need taxonomy champions, too

269. Distributed peer review: how Ukraine has reaped the benefits and minimized the risks

270. How fungus-farming ants have nourished biology for 150 years

271. Western science diplomacy must rethink its biases and treat all partners equally

272. Daily briefing: Lots of sugar as a child raises the risk of diabetes as an adult

273. ‘A big, big win’: plan to pay for wildlife conservation emerges at biodiversity summit

274. I had to let a student go and I feel as though I failed them — how do I do better next time?

275. How I hunt down fake degrees and zombie universities

276. I track bird movement to enhance conservation efforts

277. The scale of the biodiversity crisis laid bare

278. Daily briefing: ‘Impossible’ molecules break 100-year old chemical rule

279. Five structural-biology questions that still challenge AI

280. Mojave Ghost: an emotive journey along the San Andreas Fault

281. The world’s oldest tree? Genetic analysis traces evolution of iconic Pando forest

282. Daily briefing: Variant of mpox virus is getting better at human-to-human transmission

283. The eight obituaries of a Shanghai person

284. Chemists make ‘impossible’ molecules that break 100-year-old bonding rule

285. Naked mole rats vanquish genetic ghosts — and achieve long life

286. Diabetes risk soars for adults who had a sweet tooth as kids

287. See a giant ‘ghost particle’ detector and more — October’s best science images

288. The seas are on the rise — and that surge is accelerating

289. Hidden players: the bacteria-killing viruses of the gut microbiome

290. Daily briefing: How to mentally recover from an extreme weather event

291. How does overeating lead to diabetes? A surge of neurotransmitters

292. Anti-obesity drug has life-changing benefits for arthritis

293. Ultra-precise 3D maps of cancer cells unlock secrets of how tumours grow

294. Engineered receptors show how humans tell countless odour molecules apart

295. Thirty years since the race to the BRCA1 gene

296. Strain could enable energy-saving computer memories

297. A thaw in scientific relations could help clear the air in India and Pakistan

298. Brown dwarf in neighbouring solar system is actually a spinning duo

299. The genetic legacy of the wild ancestors of modern cattle

300. Monkeypox virus keeps getting better at spreading among humans