1. How to understand exoplanets — space scientists call on lab-based chemists to help

2. How do you know what I know you know? Steven Pinker on common knowledge

3. Daily briefing: Key coral species are functionally extinct after record-breaking heatwave

4. China seeks self-reliance in science in next five-year plan

5. The sci-fi films that physicists love to watch

6. How Napoleon’s army met its doom: DNA reveals surprise illnesses had a role

7. Chen-Ning Yang obituary: intuitive physicist whose theories on broken symmetries were proved right

8. Sugarcane genomes offer sweet surprise: mystery ancestor

9. Ancient graffiti and brain complexities: Books in brief

10. How to grow crystals when and where you want them

11. Daily briefing: People with cancer lived longer if they’d had a COVID-19 vaccine

12. AI chatbots are sycophants — researchers say it''s harming science

13. Audio long read: How to get the best night’s sleep — what the science says

14. Paper or plastic?

15. These iconic corals are nearly extinct due to heatwaves: can they be saved?

16. This AI method could turbocharge the hunt for new medicines

17. Does gravity produce quantum weirdness? Proposal divides physicists

18. This luxury ‘cat poo’ coffee has a unique flavour: what’s behind it?

19. Daily briefing: Stinkbugs nurture fungi in a newly discovered organ

20. Daily briefing: People with macular degeneration can read again after retinal implant

21. Google Scholar tool gives extra credit to first and last authors

22. Google AI aims to make best-in-class scientific software even better

23. Author Correction: Structures of α-synuclein filaments from multiple system atrophy

24. Surprise meteorite debris uncovered on Moon’s far side

25. Google claims ‘quantum advantage’ again — but researchers are sceptical

26. Gene implicated in the heart defects associated with Down’s syndrome

27. Is there a ‘smoking gun’ test for quantum gravity?

28. AI discovers learning algorithm that outperforms those designed by humans

29. Evolutionary history of stony corals suggests that some could be resilient to climate change

30. Tumours might be sensitized to immune therapy by COVID mRNA vaccines

31. People with some cancers live longer after a COVID vaccine

32. Copper-free chips generate robust ‘combs’ of multicoloured light

33. Neuroendocrine control of calcium mobilization in the fruit fly

34. Video‐rate tunable colour electronic paper with human resolution

35. Integration of hunger and hormonal state gates infant-directed aggression

36. Non-van der Waals superlattices of carbides and carbonitrides

37. Observation of constructive interference at the edge of quantum ergodicity

38. Bottom-up design of Ca2 channels from defined selectivity filter geometry

39. Cryogenic X-ray photoelectron spectroscopy for battery interfaces

40. Mapping Plasmodium transitions and interactions in the Anopheles female

41. Joint neutrino oscillation analysis from the T2K and NOvA experiments

42. A global coral phylogeny reveals resilience and vulnerability through deep time

43. SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade

44. Designing allosteric modulators to change GPCR G protein subtype selectivity

45. Transcriptional interferences ensure one olfactory receptor per ant neuron

46. A circular economy approach for the global lithium-ion battery supply chain

47. Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21

48. Oxidative potential of atmospheric particles in Europe and exposure scenarios

49. A metallic p-wave magnet with commensurate spin helix

50. Deterministic soliton microcombs in Cu-free photonic integrated circuits

51. Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion

52. Optimization by decoded quantum interferometry

53. Classical theories of gravity produce entanglement

54. Uncertain climate effects of anthropogenic reactive nitrogen

55. Honey, I ate the kids: how hunger and hormones make mice aggressive

56. Reply to: Uncertain climate effects of anthropogenic reactive nitrogen

57. Discovering state-of-the-art reinforcement learning algorithms

58. Measles, polio, tuberculosis: what’s causing spikes in infectious diseases?

59. Four game-changing immunology tools to watch

60. We need more than good science to fight infectious disease

61. Here there be

62. The search for mutations that sperm acquire as men age

63. Sex differences in depression revealed by large genetics study

64. Pancreatic cancer relies on opposing signalling pathways to drive its cellular diversity

65. How to spot fake scientists and stop them from publishing papers

66. What makes PhD students happy? Good supervision

67. US PhD admissions shrink as fears over Trump’s cuts take hold

68. ‘Gland-in-a-dish’ secretes stress hormone like the real thing

69. Stinkbug ‘ear’ actually hosts parasite-fighting fungi

70. Hopes of realizing a dream ‘city of health’

71. Daily briefing: Time to retire the Turing test?

72. Universities are embracing AI: will students get smarter or stop thinking?

73. Cake to the rescue: how these PhD students are cooking up a sense of community

74. The TrumpRx website won’t slash drug prices — but this will

75. Genetics can give evolving societies a leg up

76. The race for deep-sea minerals could cause geopolitical and ecological harm

77. Take the time to ensure that AI is safe

78. Brazil must beef up its COP30 scheme to preserve tropical forests

79. Breastfeeding boosts immune cells that protect against breast cancer

80. How scientists are pushing back against Trump’s funding ‘deal’ for universities

81. People with blindness can read again after retinal implant

82. What’s the cap on human energy expenditure? Elite athletes reveal ‘metabolic ceiling’

83. Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers

84. Parity and lactation induce T cell mediated breast cancer protection

85. Selective Methylene Oxidation in α,β-Unsaturated Carbonyl Natural Products

86. Are these the happiest PhD students in the world?

87. Why we still don’t understand the Universe — even after a century of dispute

88. Disconnecting part of the brain sends it into a deep sleep

89. Cold plunge: how I gained hands-on experience in marine biology

90. Daily briefing: Gene that causes obesity also shields against heart disease

91. Daily briefing: How the brain locks in long-term memories

92. Alternatives to animal testing are the future — it’s time that journals, funders and scientists embrace them

93. AI language models killed the Turing test: do we even need a replacement?

94. Why simply ending animal testing isn’t the answer in biomedical research

95. John Gurdon obituary: Biologist who made cloning possible

96. Author Correction: A room temperature rechargeable all-solid-state hydride ion battery

97. Blood tests are now approved for Alzheimer’s: how accurate are they?

98. Would ChatGPT hire you? Your age and gender matter

99. Is academic research becoming too competitive? Nature examines the data

100. Warning signs

101. Time-resolved fluorescent proteins expand the microscopy palette

102. This gene causes obesity — and shields against heart disease

103. The US and Europe have cut billions in health aid — can anyone fill the gap?

104. The problem with career planning in science

105. Parenting, illnesses and medical commitments: the private details grant reviewers shouldn’t need to know

106. Daily briefing: Making babies with lab-grown eggs and sperm

107. Mysterious ‘little red dots’ are baffling astronmers. What are they?

108. Ion stencils used for synthesis of patchy nanoparticles

109. Yeast genomes show how large genomic variations affect trait diversity

110. First known fossil hand of the hominin Paranthropus boisei

111. Using heat to power up molecular systems

112. Extreme confinement unleashes water’s hidden electrical capabilities

113. How emotional memories are engraved on the brain, with surprising helper cells

114. The evolution of facultative symbiosis in stony corals

115. Efficient quantum thermal simulation

116. Spatial metabolic gradients in the liver and small intestine

117. Hijacking a bacterial ABC transporter for genetic code expansion

118. From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes

119. New fossils reveal the hand of Paranthropus boisei

120. Niche-specific dermal macrophage loss promotes skin capillary ageing

121. A long-necked early dinosaur from a newly discovered Upper Triassic basin in the Andes

122. Aboveground biomass in Australian tropical forests now a net carbon source

123. Integrated lithium niobate photonics for sub-ångström snapshot spectroscopy

124. A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization

125. Patchy nanoparticles by atomic stencilling

126. Modern sea-level rise breaks 4,000-year stability in southeastern China

127. In-plane dielectric constant and conductivity of confined water

128. Population-specific polygenic risk scores for people of Han Chinese ancestry

129. Isolation, engineering and ecology of temperate phages from the human gut

130. A vaccine central in A(H5) influenza antigenic space confers broad immunity

131. The astrocytic ensemble acts as a multiday trace to stabilize memory

132. The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies

133. New bird flu vaccine could tackle multiple variants with one shot

134. Tin-based perovskite solar cells with a homogeneous buried interface

135. Photocatalytic oxygen-atom transmutation of oxetanes

136. Deaminative cross-coupling of amines by boryl radical β-scission

137. Wastewater treatment produces surprising amounts of greenhouse gases

138. The year of the Ghost Ant

139. How journals can break down barriers for Latin American scientists

140. Daily briefing: Could microbe-friendly buildings help us be healthier?

141. UNESCO stands at a crossroads — researchers must back its new leader

142. The quest to make babies with lab-grown eggs and sperm

143. Scientists lose jobs and grants as US government shutdown takes a toll

144. AI bots wrote and reviewed all papers at this conference

145. Gigantic black holes did not have starring role in early cosmic transition

146. The spectre of malnutrition is back and must be tackled — fast

147. Daily briefing: Corals have been pushed beyond an irreversible tipping point, says report

148. Japan declares a flu epidemic — what this means for other nations

149. Do rats double-dip food with their tails?

150. The race to uncover snow’s many mysteries before it disappears forever

151. Inside our university’s mission to pivot to research

152. The probiotic home: where microbes are welcome guests

153. Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier

154. Carbon credits are failing to help with climate change — here’s why

155. Longer grant cycles would boost research in Africa

156. AI’s therapeutic potential goes beyond emotional connection

157. Brazil’s COP30 legacy should be to protect more of its forests

158. Red lines for religious AI

159. Men’s brains shrink faster than women’s: what that means for Alzheimer’s

160. Economics Nobel prize won by researchers who showed how science boosts growth

161. ‘Am I redundant?’: how AI changed my career in bioinformatics

162. What an academic misconduct accusation taught me about sharing research

163. Host cell Z-RNAs activate ZBP1 during virus infections

164. Birds’ intruder alert hints at how sounds took on new meanings

165. Andean peoples hunted and gathered long after they embraced farming

166. Defending Ohuira Bay, Mexico

167. Metals are key to the global economy — but three challenges threaten supply chains

168. Digital flocks, predators allow ecologists to simulate real-world animal behaviour

169. Daily briefing: Don''t sideline Palestinian scientists after ceasefire, say experts

170. Alchemy: discredited pseudoscience or chemistry’s worthy ancestor?

171. Coral die-off marks Earth’s first climate ‘tipping point’, scientists say

172. Should genetically modified wildlife be banned? Scientists weigh the risks

173. The world’s first plastics treaty is in crisis: can it be salvaged?

174. Current mosquitoes evolved more recently than previously thought

175. Portable muon beam could accelerate archaeology scans

176. Dangerous ‘nitazene’ opioids are on the rise: researchers are worried

177. European bats capture migrating birds and eat them on the wing

178. Future solitude

179. Author Correction: Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus

180. Daily briefing: Chronic pain linked to small cluster of brain cells

181. Rebuilding Gaza: don''t sideline Palestinian scientists, say experts

182. Naked mole rats live for decades — genetic tweaks reveal insights into ageing

183. More than 30% of this century’s science Nobel prizewinners immigrated: see their journeys

184. This list of non-negotiables helped me to defeat PhD-student guilt

185. How to pause and restart your science career

186. First proposed blood test for chronic fatigue syndrome: what scientists think

187. Daily briefing: Chemistry Nobel for ‘super sponge’ MOFs

188. Mark Norell obituary: palaeontologist who showed that dinosaurs still walk among us — as birds

189. Hippos still roamed Europe during the last ice age

190. ‘Google for DNA’ brings order to biology’s big data

191. How stereotypes shape AI – and what that means for the future of hiring

192. Distorted representations of age and gender are reflected in AI models

193. Drones switch payloads in mid-air using a flying toolbox

194. Sacrificial metal speeds up synthesis of nano-alloys from multiple elements

195. A quantum boost for ultra-precise clocks

196. Ultra-sensitive DNA sequencing maps mutations that precede cancer

197. Tracing the ancestry of barley in time and space

198. Brain area linked to chronic pain discovered — offering hope for treatments

199. Flexible perceptual encoding by discrete gamma events

200. Programmable on-chip nonlinear photonics

201. KCTD10 is a sensor for co-directional transcription–replication conflicts

202. Quantum-amplified global-phase spectroscopy on an optical clock transition

203. Sex and smoking bias in the selection of somatic mutations in human bladder

204. Southward impact excavated magma ocean at the lunar South Pole–Aitken basin

205. A ductile chromium–molybdenum alloy resistant to high-temperature oxidation

206. Sperm sequencing reveals extensive positive selection in the male germline

207. Efficient and accurate search in petabase-scale sequence repositories

208. Somatic mutation and selection at population scale

209. A full-featured 2D flash chip enabled by system integration

210. Age and gender distortion in online media and large language models

211. Hotspots of human mutation point to clonal expansions in spermatogonia

212. A parabrachial hub for need-state control of enduring pain

213. Enzyme specificity prediction using cross attention graph neural networks

214. Daily briefing: Physics Nobel for quantum tunnelling on a macroscopic scale

215. Daily briefing: Nobel Prize for discovery of ‘brake’ on immune system

216. The girl who used to be my sister

217. Low quality papers are flooding the cancer literature — can this AI tool help to catch them?

218. Clues to why the weight-loss condition cachexia arises when cancer occurs

219. Chemistry Nobel for scientists who developed massively porous ‘super sponge’ materials

220. AI models that lie, cheat and plot murder: how dangerous are LLMs really?

221. These immune cells won Nobel fame — can they solve autoimmune disease?

222. The rise of ‘nightmare bacteria’: antimicrobial resistance in six charts

223. The EU’s Horizon research fund needs to stay a defence-free zone

224. The 1975 discovery of long-lost letters between Albert Einstein and the astronomer Willem de Sitter

225. Groundbreaking quantum-tunnelling experiments win physics Nobel

226. Customizable AI systems that anyone can adapt bring big opportunities — and even bigger risks

227. Stop treating code like an afterthought: record, share and value it

228. Incentives accelerate progress on open access in Spain

229. Microbe discovery holds promise for sustainable biotechnology

230. Stop destructive fishing in marine protected areas

231. Insect biodiversity monitoring must be expanded

232. Prizes must recognize machine contributions to discovery

233. Volunteer scientists work ‘nights and weekends’ to guide vaccine advice in US

234. Wonder, empathy, life: why we called our pregnancy-diagnostic company Mirvie

235. Connecting the dots: I trace the history of the East Kolkata Wetlands

236. Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’

237. The cutting-edge medical approaches that could transform ageing

238. Jane Goodall obituary: pioneer primatologist who inspired generations of scientists

239. 27 things we wish we’d known when we started our PhDs

240. Daily briefing: The Nobel prizes’ most prestigious rivals

241. From fossil fuels to ‘green capitalism’: the dilemmas of a just energy transition

242. Will AI ever win its own Nobel? Some predict a prize-worthy science discovery soon

243. A scientist’s guide to AI agents — how could they help your research?

244. Creative hobbies could slow brain ageing at the molecular level

245. ‘Rogue’ planet is fastest-growing ever observed

246. Weaponizing uncertainty in science and in public health puts people in harm’s way

247. First human transplant of kidney modified to have ‘universal’ blood type

248. Author Correction: Ribonucleotide incorporation into mitochondrial DNA drives inflammation

249. These science prizes want to rival the Nobels: how do they compare?

250. Marcus kinetics control singlet and triplet oxygen evolving from superoxide

251. The child of humanity becomes the mother of all

252. AI has designed thousands of potential antibiotics. Will any work?

253. Violin therapy: Books in brief

254. Daily briefing: ‘A messenger of hope’ — Jane Goodall’s impact on science

255. These alien planets are astronomers’ favourites: here’s why

256. Biothreat hunters catch dangerous DNA before it gets made

257. Scooped by a cupcake business: why we called our green-cement company Sublime Systems

258. Author Correction: EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells

259. Research assessment: a round-up for early-career researchers

260. Publisher Correction: Multimodal cell maps as a foundation for structural and functional genomics

261. Keep, lose, add: a checklist for plotting your next career move in science

262. Memorable, distinctive, not too ‘sciencey’: why we named our biotech firm Anocca

263. Exclusive: ex-CDC director talks about why she was fired

264. Model organism databases face budget cuts and closures

265. Jane Goodall’s legacy: three ways she changed science

266. Daily briefing: Fireworks in space — the month’s best science images

267. This US government shutdown is different: what it means for science

268. DNA circuits store data — with heat as their power source

269. Early- and late-diagnosed autism are genetically distinct

270. Parachutes inspired by the Japanese art of kirigami

271. Bacteria use a decoy defence molecule to set a trap for viruses

272. Ancient viral DNA in the human genome shapes early development

273. Quantum correlations enhance the sensitivity of room-temperature sensors

274. Features of autism can affect age of diagnosis – and so can genes

275. Machine learning matches enzymes with molecular substrates

276. Mix-and-match fossils tell the tale of snake and lizard evolution

277. A pathway that controls conversion of the amino acid cysteine into a cholesterol regulator

278. Elaborate machinery for inserting proteins into the outer membrane of bacteria

279. Evolution of drug-resistant ovarian-cancer clones tracked in patients

280. End GDP mania: how the world should really measure prosperity

281. Spin squeezing in an ensemble of nitrogen–vacancy centres in diamond

282. Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis

283. Long-distance remote epitaxy

284. A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling

285. The Panoptes system uses decoy cyclic nucleotides to defend against phage

286. A human-specific regulatory mechanism revealed in a pre-implantation model

287. Doughnut of social and planetary boundaries monitors a world out of balance

288. Mosaic anatomy in an early fossil squamate

289. Connecting chemical and protein sequence space to predict biocatalytic reactions

290. Tracking clonal evolution during treatment in ovarian cancer using cell-free DNA

291. Polygenic and developmental profiles of autism differ by age at diagnosis

292. Monoclonal antibodies protect against pandrug-resistant Klebsiella pneumoniae

293. Heat-rechargeable computation in DNA logic circuits and neural networks

294. Signal amplification in a solid-state sensor through asymmetric many-body echo

295. A new paradigm for outer membrane protein biogenesis in the Bacteroidota

296. Dietary cysteine enhances intestinal stemness via CD8 T cell-derived IL-22

297. Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death

298. Kirigami-inspired parachutes with programmable reconfiguration

299. Proteotoxic stress response drives T cell exhaustion and immune evasion

300. These laser-cut discs turn into super precise parachutes