1. Exclusive: documents reveal how NIH will axe climate studies

2. How skunk cabbages and other smelly plants brew their foul odour

3. Renewal of NIH grants linked to more innovative results, study finds

4. How quickly do humans mutate? Four generations help answer the question

5. Guess how much of the ocean floor humans have explored

6. P hacking — Five ways it could happen to you

7. Daily briefing: A spinal tumour was removed through a person’s eye socket for the first time

8. Curiosity, drive, willingness to learn: three qualities to display at science job interviews

9. Microbe that infests hospitals can digest medical-grade plastic ― a first

10. Detailed mouse brain map created with off-the-shelf microscope

11. How climate change will burden our children: data reveal a lifetime of extreme heat

12. Trump freezes ‘gain of function’ pathogen research ― threatening all US virology, critics say

13. Author Correction: Matrix-producing neutrophils populate and shield the skin

14. Brain tissue artificially expanded to show how neurons wire together

15. Time for adults to finally act like adults on climate change

16. Uncovering a key enzyme opens possible therapeutic avenues for lysosomal diseases

17. Lipid-degrading small molecule kills cancer cells by ferroptosis

18. How we taste sweetness: long-sought structure of human receptor mapped at last

19. Superb starlings swap helper and breeder roles with kin and non-kin

20. Blocking a key node in cancer signalling unlocks therapeutic potential

21. Engineered bacteria can degrade five wastewater pollutants at the same time

22. Climate risk for younger generations is set to soar

23. Chromatin loops are an ancestral hallmark of the animal regulatory genome

24. A cryptic role for reciprocal helping in a cooperatively breeding bird

25. Motor learning refines thalamic influence on motor cortex

26. Nasal vaccines for respiratory infections

27. Activation of lysosomal iron triggers ferroptosis in cancer

28. Deep origin of eukaryotes outside Heimdallarchaeia within Asgardarchaeota

29. Superconductivity and spin canting in spin–orbit-coupled trilayer graphene

30. Native nucleosomes intrinsically encode genome organization principles

31. Trends in the seasonal amplitude of atmospheric methane

32. Herring spawned poleward following fishery-induced collective memory loss

33. Targeting the SHOC2–RAS interaction in RAS-mutant cancers

34. Dopamine D1–D2 signalling in hippocampus arbitrates approach and avoidance

35. Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours

36. Striatum supports fast learning but not memory recall

37. Oncogene aberrations drive medulloblastoma progression, not initiation

38. Light-microscopy-based connectomic reconstruction of mammalian brain tissue

39. Intragrain 3D perovskite heterostructure for high-performance pure-red perovskite LEDs

40. Bioremediation of complex organic pollutants by engineered Vibrio natriegens

41. PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease

42. Twist-programmable superconductivity in spin–orbit-coupled bilayer graphene

43. Global emergence of unprecedented lifetime exposure to climate extremes

44. Herring population loses migration ''memory'' after heavy fishing

45. Why you should write your PhD thesis backwards

46. ‘Second chance’: convicted US chemist Charles Lieber moves to Chinese university

47. Leviathan

48. ‘Forever’ molecules arrange themselves into cell-like structures

49. How Korea’s female divers have adapted to cold plunges

50. Publisher Correction: Stress dynamically modulates neuronal autophagy to gate depression onset

51. Daily briefing: AI companions — friend or frenemy?

52. Tracking older LGBTQ people’s health: ‘I hear their voices and their stories’

53. Why China needs to review its approach to research evaluation

54. UK funds controversial geoengineering projects to trial Earth-cooling tech

55. How protein-slayer drugs could beat some of the cruellest cancers

56. Medical AI trained on whopping 57 million health records

57. AI reveals title of ‘unreadable’ Vesuvius scroll for first time

58. Naturally ornate RNA-only complexes revealed by cryo-EM

59. Molecular basis of SIFI activity in the integrated stress response

60. A kinase mediator of rhizobial symbiosis and immunity in Medicago

61. Make science more collegial: why the time for ‘adversarial collaboration’ has come

62. Avian vandals demolish spring flowers

63. How I honed my biopharma dealmaking and business-development skills after my PhD

64. Cuts to US science will take a generation to repair — leaders must speak up now

65. Supportive? Addictive? Abusive? How AI companions affect our mental health

66. Daily briefing: The unusual mathematics that gives rose petals their shape

67. Can Germany rein in its academic bullying problem?

68. Manage releases of ‘forever chemicals’ in lab waste

69. Next CERN collider has community input

70. USAID’s shutdown: a crisis for sub-Saharan Africa

71. In science-for-policy design, one size doesn’t fit all

72. Don’t need much sleep? Mutation linked to thriving with little rest

73. Teens with anxiety and depression spend more time on social media

74. I climb mountains in search of sustainable agricultural systems

75. Want to supercharge your science? Turn to technicians

76. Trump proposes unprecedented budget cuts to US science

77. Author Correction: Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning

78. Blood of man who’s had 200 snake bites helps make a potent antivenom

79. Star ecologist ‘blurred boundaries’ in lab — but colleagues criticize investigation

80. Trump gutted two landmark environmental reports — can researchers save them?

81. AI scientist ‘team’ joins the search for extraterrestrial life

82. Daily briefing: A supersingular elliptic curve brought to life — the month’s best science images

83. Walking in two worlds: how an Indigenous computer scientist is using AI to preserve threatened languages

84. Searching for dark photons in the Sun’s atmosphere

85. Fungus from the human gut slows liver disease in mice

86. Exclusive: NSF stops awarding new grants and funding existing ones

87. Storm of seizures in a baby’s brain calms after trial therapy

88. Powerful protein editors offer new ways of probing living cells

89. Revealed: the unusual mathematics that gives rose petals their shape

90. Why the green-technology race might not save the planet

91. Whale earwax, fungal fertilizer and chocolate emissions: exhibition explores biodiversity research

92. Daily briefing: 17 ways to ward off stroke, dementia or depression later in life

93. Exclusive: NIH to suspend funds for research abroad as it overhauls policy

94. One of the world’s richest lithium deposits began inside a mega-volcano

95. Trump team’s science cuts threaten tenure hopes for early-career academics

96. Nickel production is notoriously dirty — here’s how to make it greener

97. Metal-cored molecule is the first of its kind

98. Indigenous American tribe’s ancestral history confirmed by genomes

99. Did a tardigrade get the world’s tiniest tattoo? April’s best science images

100. Inflammatory bowel disease has stages of epidemiology that can be tracked across global regions

101. Native American tribe teams up with genomicists to confirm link to iconic ancient site

102. The cell-division cycle is faster in cell types prone to forming cancer

103. Observation of edge and bulk states in a three-site Kitaev chain

104. Comparative connectomics of Drosophila descending and ascending neurons

105. Sustainable nickel enabled by hydrogen-based reduction

106. Plant diversity dynamics over space and time in a warming Arctic

107. Single-cell transcriptomics reveal how root tissues adapt to soil stress

108. An asymmetric fission island driven by shell effects in light fragments

109. A battery-free nanofluidic intracellular delivery patch for internal organs

110. Serotonin and neurotensin inputs in the vCA1 dictate opposing social valence

111. Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis

112. Using life cycle assessment to drive innovation for sustainable cool clouds

113. Regulation of PV interneuron plasticity by neuropeptide-encoding genes

114. Pacific hotspots reveal a Louisville–Ontong Java Nui tectonic link

115. The distribution of subsurface microplastics in the ocean

116. Global evolution of inflammatory bowel disease across epidemiologic stages

117. Picuris Pueblo oral history and genomics reveal continuity in US Southwest

118. Structurally complex phase engineering enables hydrogen-tolerant Al alloys

119. Cell cycle duration determines oncogenic transformation capacity

120. TIR domains produce histidine-ADPR as an immune signal in bacteria

121. Diet outperforms microbial transplant to drive microbiome recovery in mice

122. Adversarial testing of global neuronal workspace and integrated information theories of consciousness

123. Metal-centred planar [15]annulenes

124. The dismantling of US science: can it survive Trump 2.0?

125. A MERS-CoV-like mink coronavirus uses ACE2 as entry receptor

126. A DNA-gated molecular guard controls bacterial Hailong anti-phage defence

127. Romeo and the robots

128. How we call out the infuriating mistakes we spot in school science textbooks

129. Trump blew up the global fight against AIDS. Can it recover?

130. The end of AIDS is in sight: don’t abandon PEPFAR now

131. Daily briefing: COVID booster jabs given in the same arm as the original work faster

132. Why we need to measure people’s well-being — lessons from a global survey

133. How to protect research data

134. For these bats, eavesdropping is a valuable learnt skill

135. Canada’s election: what Mark Carney’s win means for science

136. Tattoo-making tools used by ancient Maya revealed

137. Historic pandemic treaty is a triumph in a world being torn apart

138. When a great ball of fire came crashing down

139. ‘Fear extinction’ signal in mouse brain offers clues about how to treat PTSD

140. COVID vaccine works faster with both doses in the same arm

141. Will US science survive Trump 2.0?

142. The do’s and don’ts of scientific image editing

143. Debris from rockets is polluting the Caribbean

144. Preserve access to crucial climate data

145. The use of AI in peer review could undermine science

146. Cell classification should be based on more than just DNA

147. Daily briefing: Bite marks on bones hint that Romans really did fight lions

148. Microbial molecule of ageing gut nudges blood stem cells towards cancer

149. Publisher Correction: irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein assemblies on RNA

150. A forensic investigator of glacier change

151. My fight to unlock cannabis and psychedelic drugs for use in medical research

152. Daily briefing: Fibromyalgia eases after doses of gut microbes

153. Academia needs a more honest, scientific approach to DEI

154. How the world’s largest language family spread — and why others go extinct

155. Hundreds more NSF grants terminated after agency director resigns

156. My ‘woke DEI’ grant has been flagged for scrutiny. Where do I go from here?

157. This is not the new colour that scientists have created

158. Huge reproducibility project fails to validate dozens of biomedical studies

159. Audio long read: Do smartphones and social media really harm teens’ mental health?

160. ‘Tatooine’-like planet orbits two stars ― but at a weird angle

161. Daily briefing: Ancient Phoenicians spread their culture — but not their DNA

162. Major European institutes join race to save US science data

163. How Trump’s attack on universities is putting research in peril

164. How Democrats and Republicans cite science: study reveals stark differences

165. Baffling chronic pain eases after doses of gut microbes

166. Editorial Expression of Concern: A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

167. Editorial Expression of Concern: Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

168. Science sleuths flag hundreds of papers that use AI without disclosing it

169. Parkinson’s gut-microbiota links raise treatment possibilities

170. Eugenics is on the rise again: human geneticists must take a stand

171. Daily briefing: Sea-turtle conservation is working

172. Why US police shootings are so deadly ― and why some police forces do better

173. A front-line antiviral drug disappoints against worrisome monkeypox strain

174. The text of dozens of burnt Herculaneum scrolls could soon be revealed

175. Century-old genetics mystery of Mendel’s peas finally solved

176. A brand-new colour created by lasers, a pig-liver transplant trial gets the green light, and a nugget-sized chunk of lab-grown meat

177. Quantum communication across a 250-kilometre optical-fibre network

178. Blood cancer driven by ‘one hit’ mutation event undergoes rapid growth

179. mRNA technology helps reinvigorate the hunt for cancer vaccines

180. Memories of a cold place trigger bodily responses to warm up

181. Heart-attack outcomes are worse in the morning when activity of protein duo dips

182. Cancer vaccine momentum builds, but US funding cuts raise concerns

183. A protein tunnel that shuttles lipids around the cell

184. Shapeshifting origami material shrinks when twisted

185. Psychedelics reduce fear by targeting immune cells that modulate brain cells

186. Answers to a 160-year-old riddle about the genetics of Mendel’s pea traits

187. Tracking the evolution and persistence of antibiotic resistance in the human gut

188. Structural basis of lipid transfer by a bridge-like lipid-transfer protein

189. Brief antibiotic use drives human gut bacteria towards low-cost resistance

190. Punic people were genetically diverse with almost no Levantine ancestors

191. Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer

192. A distributed coding logic for thermosensation and inflammatory pain

193. Human de novo mutation rates from a four-generation pedigree reference

194. Genomic and genetic insights into Mendel’s pea genes

195. Targeting PIKfyve-driven lipid metabolism in pancreatic cancer

196. Melt focusing along lithosphere–asthenosphere boundary below Axial volcano

197. Modular chiral origami metamaterials

198. Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1

199. Quantum twisting microscopy of phonons in twisted bilayer graphene

200. BMAL1–HIF2A heterodimer modulates circadian variations of myocardial injury

201. Long-distance coherent quantum communications in deployed telecom networks

202. Effects of glacial forcing on lithospheric motion and ridge spreading

203. Atomic lift-off of epitaxial membranes for cooling-free infrared detection

204. Cold memories control whole-body thermoregulatory responses

205. Deciphering disordered regions controlling mRNA decay in high-throughput

206. Carbon majors and the scientific case for climate liability

207. Superconducting gap of H3S measured by tunnelling spectroscopy

208. Psychedelic control of neuroimmune interactions governing fear

209. Ancient DNA poses puzzle of why Phoenicians spread culture but not their genes

210. An origami design for metamaterial robots

211. Geographic and age variations in mutational processes in colorectal cancer

212. Whole-body physics simulation of fruit fly locomotion

213. Daily briefing: Potato pangenome reveals the complex genetics of the humble spud

214. How AI is helping to boost cancer screening

215. Four rising stars at the forefront of cancer research

216. Clinical trials by the numbers

217. China overtakes the United States in cancer research output

218. Wild strawberries on Mars

219. Publisher Correction: Oncolytic virus VG161 in refractory hepatocellular carcinoma

220. How we’re battling Trump’s science cuts across small-town America

221. Scientific naming conventions should keep in step with contemporary science

222. Author Correction: Global influence of soil texture on ecosystem water limitation

223. Three ways to cool Earth by pulling carbon from the sky

224. Custom CRISPR—Cas9 PAM variants via scalable engineering and machine learning

225. Substrate recognition and cleavage mechanism of the monkeypox protease, Core protease

226. Stereoretentive radical cross-coupling

227. Kidney disease is a worldwide killer. Treat it that way

228. Top of the crops: rice scientists seek to meet global food demands

229. Arctic researchers need to find ways to keep working together

230. Author Correction: Structure of the human dopamine transporter in complex with cocaine

231. Which programming language should I use? A guide for early-career researchers

232. Exclusive: a Nature analysis signals the beginnings of a US science brain drain

233. ‘Dark matter’, ''Big Bang'' and ‘spin’: how physics terms can confuse researchers

234. Daily briefing: The biggest single piece of meat ever grown in the lab

235. Sexual harassment thrives in silence, even in gender-equality hotspots

236. The global assault on universities is an attack on democracy

237. Trade tariffs could worsen deforestation in South America

238. Defend scientific integrity and academic freedom

239. Europe must become a research epicentre as US system gets undermined

240. How India rewrote the rules of space travel when it launched its first satellite

241. Brand-new colour created by tricking human eyes with laser

242. Exclusive: Trump team freezes new NSF awards — and could soon axe hundreds of grants

243. Signs of life on a distant planet? Not so fast, say these astronomers

244. Martian rock hints at ancient dense atmosphere

245. Microplastic pollution found in insect casing from 1971

246. Invasion of the ‘journal snatchers’: the firms that buy science publications and turn them rogue

247. Daily briefing: The first colossal squid caught on camera in its natural habitat

248. ‘Totally broken’: how Trump 2.0 has paralysed work at US science agencies

249. 25 million deaths: what could happen if the US ends global health funding

250. Whole-genome sequencing susses out rare diseases

251. Sowing solutions: my quest to save Kenya’s maize from a devastating invader

252. Author Correction: Continued Atlantic overturning circulation even under climate extremes

253. Why politicians manipulate statistics — and what to do about it

254. The lunatic is on the grass: Books in brief

255. Winner, winner, lab-made dinner! Team grows nugget-sized chicken chunk

256. ‘Big leap’ for Parkinson’s treatment: symptoms improve in stem-cells trials

257. SWOT satellite provides a finer view of climate-driving ocean dynamics

258. Highly sensitive method captures rare RNAs in blood to search for disease

259. Unlocking the diversity of wild and domesticated rice

260. Japan’s big bet on stem-cell therapies might soon pay off with breakthrough therapies

261. Clinical trials test the safety of stem-cell therapy for Parkinson’s disease

262. Don’t rush promising stem-cell therapies

263. Age-related blood condition counteracted with a common diabetes drug

264. The first observation of ‘plastic ice’ reveals unusual behaviour of water molecules

265. Negative thermal expansion and oxygen-redox electrochemistry

266. Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease

267. Low overlap of transcription factor DNA binding and regulatory targets

268. Wide-swath satellite altimetry unveils global submesoscale ocean dynamics

269. Deep Visual Proteomics maps proteotoxicity in a genetic liver disease

270. Generation of human adult hepatocyte organoids with metabolic functions

271. Towards multimodal foundation models in molecular cell biology

272. Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines

273. Histone H1 deamidation facilitates chromatin relaxation for DNA repair

274. Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation

275. Antiferromagnetic quantum anomalous Hall effect under spin flips and flops

276. The growing memristor industry

277. Chromosome end protection by RAP1-mediated inhibition of DNA-PK

278. Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease

279. Driven bright solitons on a mid-infrared laser chip

280. A sharp volatile-rich cap to the Yellowstone magmatic system

281. Subnanosecond flash memory enabled by 2D-enhanced hot-carrier injection

282. Observation of the axion quasiparticle in 2D MnBi2Te4

283. An ultrasensitive method for detection of cell-free RNA

284. Structure of the ATP-driven methyl-coenzyme M reductase activation complex

285. A pangenome reference of wild and cultivated rice

286. Multi-zonal liver organoids from human pluripotent stem cells

287. Electric-field-induced domain walls in wurtzite ferroelectrics

288. Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs

289. The phased pan-genome of tetraploid European potato

290. Bovine H5N1 binds poorly to human-type sialic acid receptors

291. Natively expressed AcrIII-1 does not function as an anti-CRISPR protein

292. Receptor-binding specificity of a bovine influenza A virus

293. What a trove of potato genomes reveals about the humble spud

294. A. J. Eisfeld et al. reply

295. Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

296. Reply to: Natively expressed AcrIII-1 does not function as an anti-CRISPR protein

297. Spain adapts to new reality as climate crisis hits home

298. Meet the researchers pioneering Spanish climate solutions

299. Healthy soil is the hidden ingredient — here’s how I’m fighting to save it

300. How a hydrogen lab is helping to power Spain’s green-energy shift