1. AlphaFold is running out of data — so drug firms are building their own version

2. Synaptic and neural behaviours in a standard silicon transistor

3. Gigantic birth study paints most detailed picture of pregnancy’s toll on body

4. A superbug rose to the top after gaining a chemical weapon

5. Lasso-shaped molecule is a new type of broad-spectrum antibiotic

6. Recovery of fluoride from ‘forever chemicals’ could lead to circular economy for fluorine

7. A lighthouse galaxy shines unexpectedly through the fog of the cosmic dawn

8. Track gender ratios in research to keep countries, institutions and publishers accountable

9. A map of mitochondrial biology reveals the energy landscape of the human brain

10. Crucial meeting: molecule helps vaccine to interact with killer T cells

11. Neuronal receptors at body temperature reveal their gating mechanics

12. New antibiotic that kills drug-resistant bacteria discovered in technician’s garden

13. First map of human brain mitochondria is ‘groundbreaking’ achievement

14. Global marine heatwave of 2023–24 was viewed as unlikely but not impossible given current warming

15. Gender gap in research publishing is improving — slowly

16. Certified randomness using a trapped-ion quantum processor

17. The other climate crisis

18. STING agonist-based ER-targeting molecules boost antigen cross-presentation

19. Witnessing the onset of reionization through Lyman-α emission at redshift 13

20. Multimodal generative AI for medical image interpretation

21. Connectome-driven neural inventory of a complete visual system

22. A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein

23. A prospective code for value in the serotonin system

24. Changes in neurotensin signalling drive hedonic devaluation in obesity

25. Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3

26. A human brain map of mitochondrial respiratory capacity and diversity

27. The global human impact on biodiversity

28. The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes

29. Macrophages harness hepatocyte glutamate to boost liver regeneration

30. A coronavirus assembly inhibitor that targets the viral membrane protein

31. Plasticity of the mammalian integrated stress response

32. Catalytic allylation of native hexoses and pentoses in water with indium

33. A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

34. irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein assemblies on RNA

35. Deconstruction of rubber via C–H amination and aza-Cope rearrangement

36. Gene-modified pig-to-human liver xenotransplantation

37. The contribution of de novo coding mutations to meningomyelocele

38. Oxidation of retromer complex controls mitochondrial translation

39. Glutamate gating of AMPA-subtype iGluRs at physiological temperatures

40. BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments

41. Solidification of Earth’s mantle led inevitably to a basal magma ocean

42. Phosphate-enabled mechanochemical PFAS destruction for fluoride reuse

43. New lasso-shaped antibiotic kills drug-resistant bacteria

44. Long-term impact and biological recovery in a deep-sea mining track

45. The full lethal impact of massive cuts to international food aid

46. Some assembly required

47. Why is there more matter than antimatter? CERN result offers tantalizing new clue

48. Mathematician who reshaped theory of symmetry wins Abel Prize

49. Daily briefing: Why women are far more likely to develop Alzheimer’s than men

50. Empower families to lead the design of their ageing loved ones’ health care

51. AI is transforming peer review — and many scientists are worried

52. Exclusive: NIH to cut grants for COVID research, documents reveal

53. Trump administration sued over huge funding cuts at Columbia University

54. Life-giving oxygen is wafting out of lakes worldwide

55. How a scientist–pop industry partnership slashed a live gig’s carbon emissions by 98%

56. Ancient shackles testify to brutality of Egypt’s gold mines

57. Meet ‘qudits’: more complex cousins of qubits boost quantum computing

58. MFSD6 is an entry receptor for enterovirus D68

59. Why is my cello howling?

60. Climate change will send home insurance spiralling. Here’s how to control costs

61. How the Atlantic jet stream has changed in 600 years — and what it means for weather

62. Fasting for weight loss is all the rage: what are the health benefits?

63. Daily briefing: Babies make memories — so why don’t we recall them?

64. Microbes can capture carbon and degrade plastic — why aren’t we using them more?

65. How to get more women into mining

66. Lesotho matters

67. Give grants to female scientists in war zones

68. Lessons from Portugal on effects of cutting research funding

69. ‘Anxiety is palpable’: detention of researchers at US border spurs travel worries

70. Live-cell super-resolution microscopy reveals how molecules enter and exit the nucleus

71. Does sharing first authorship on a paper carry a penalty? What the research says

72. What CERN does next matters for science and for international cooperation

73. Marathon runners tap brain-cell insulation for racetime fuel

74. Generalizing arene CH alkylations by radicalradical cross-coupling

75. Reviving the biodiversity around an ancient palace

76. Shaking up earthquake safety in Nepal with a folk song

77. Paralysed man stands again after receiving ‘reprogrammed’ stem cells

78. RNA function follows form – why is it so hard to predict?

79. The expanding Universe — do ongoing tensions leave room for new physics?

80. Winds on an ultrahot planet challenge climate models

81. Glaciers are not just blocks of ice — plans to save them mustn’t overlook their hidden life

82. How to know whether a conference is right for you

83. Why Africans should be telling the story of human origins

84. Publisher Correction: A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion

85. NIH has cut one mRNA-vaccine grant. Will more follow?

86. ‘Boggles the mind’: US defence department slashes research on emerging threats

87. Author Correction: AI models collapse when trained on recursively generated data

88. Author Correction: Heritable polygenic editing: the next frontier in genomic medicine?

89. Daily briefing: The mysterious force pushing galaxies apart might be getting weaker

90. ‘All this is in crisis’: US universities curtail staff, spending as Trump cuts take hold

91. Ship-pollution cuts have an electrifying effect: less lightning at sea

92. Trump team ‘survey’ sent to overseas researchers prompts foreign interference fears

93. Author Correction: Spatially resolved multiomics of human cardiac niches

94. Babies do make memories — so why can’t we recall our earliest years?

95. End-to-end data-driven weather prediction

96. Bulk superconductivity near 40 K in hole-doped SmNiO2 at ambient pressure

97. Daily briefing: About 1% of children have genetic paternity other than that recorded by history

98. How ‘animal methods bias’ is affecting research careers

99. Author Correction: Observation of an ultra-high-energy cosmic neutrino with KM3NeT

100. Is dark energy getting weaker? Fresh data bolster shock finding

101. Can Earth’s rotation generate power? Physicists divided over controversial claim

102. Could libraries band together to ensure open access for all?

103. Tiny satellite sets new record for secure quantum communication

104. What is the best type of tree to use for forest restoration?

105. A practical leap towards secure quantum communication over long distances

106. A textbook assumption about the brain’s most abundant receptors needs to be rewritten

107. New antifungal breaks the mould

108. Mutations that accrue through life set the stage for stomach cancer

109. Immune cells ‘bandage’ wounds with bacteria-trapping goo

110. Mini-satellite paves the way for quantum messaging anywhere on Earth

111. Bird brains help scientists to unveil the secrets of speech

112. Ancient peat reveals that sea level surged rapidly twice at the end of the last ice age

113. Optimizing generative AI by backpropagating language model feedback

114. Matrix-producing neutrophils populate and shield the skin

115. Microsatellite-based real-time quantum key distribution

116. Transient silencing of hypermutation preserves B cell affinity during clonal bursting

117. Sleep pressure accumulates in a voltage-gated lipid peroxidation memory

118. Histological signatures map anti-fibrotic factors in mouse and human lungs

119. The somatic mutation landscape of normal gastric epithelium

120. Cooper-pair density modulation state in an iron-based superconductor

121. Long-term studies provide unique insights into evolution

122. Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium

123. Global sea-level rise in the early Holocene revealed from North Sea peats

124. GluA2-containing AMPA receptors form a continuum of Ca2-permeable channels

125. Oncolytic virus VG161 in refractory hepatocellular carcinoma

126. Spatially resolved mapping of cells associated with human complex traits

127. Hyperbolic phonon-polariton electroluminescence in 2D heterostructures

128. Electroluminescence and energy transfer mediated by hyperbolic polaritons

129. Water structure and electric fields at the interface of oil droplets

130. Structural dynamics of DNA unwinding by a replicative helicase

131. Overlapping nuclear import and export paths unveiled by two-colour MINFLUX

132. Rapid emergence of latent knowledge in the sensory cortex drives learning

133. Convergent vocal representations in parrot and human forebrain motor networks

134. Down-converted photon pairs in a high-Q silicon nitride microresonator

135. Regulated somatic hypermutation enhances antibody affinity maturation

136. VDAC2 loss elicits tumour destruction and inflammation for cancer therapy

137. A polyene macrolide targeting phospholipids in the fungal cell membrane

138. Widespread slow growth of acquisitive tree species

139. Drivers of avian genomic change revealed by evolutionary rate decomposition

140. Fluctuating magnetism and Pomeranchuk effect in multilayer graphene

141. Downscaling micro- and nano-perovskite LEDs

142. World’s tiniest LED display has pixels smaller than a virus

143. Why humans have puzzle-shaped cells

144. Measles is surging in the US: how bad could it get?

145. What is stopping a complete switch to clean energy?

146. How the US tech industry is shaping the transition to green energy

147. A guide to the Nature Index

148. Battery researchers strive for standardization

149. Trump’s return puts renewables at a crossroads

150. Meeting the energy challenge posed by data centres is central to a green future

151. AI could soon tackle projects that take humans weeks

152. Asia leads rise in clean-energy research

153. Disconnections

154. Daily briefing: Iguanas from the Americas might have rafted to Fiji

155. The biggest machine in science: inside the fight to build the next giant particle collider

156. Light pollution threatens fleet of world-class telescopes in Atacama Desert

157. Microsoft quantum computing claim still lacks evidence: physicists are dubious

158. Iguanas reached Fiji by floating 8,000 kilometres across the sea

159. Food-industry waste finds a second life as bioplastic

160. Vaccines save lives. Leaders must champion them

161. Structures and mechanism of human mitochondrial pyruvate carrier

162. Daily briefing: Jurassic mammals had dark fur

163. An experiment in mass education using satellite TV

164. Catchy, clear, concise: Three-part phrases boost research paper citations

165. Cleaning up space: how satellites and telescopes can live together

166. Governments must stop hoarding climate data

167. Swarms of satellites are harming astronomy. Here’s how researchers are fighting back

168. Space debris is falling from the skies. We need to tackle this growing danger

169. Japan needs a fresh approach to innovation

170. AI demands a different approach to education

171. Global cooperation is crucial for DeepSeek and broader AI research

172. US disruptions to science could transform global research landscape

173. Author Correction: Endocytosis in the axon initial segment maintains neuronal polarity

174. What’s in store for US science as funding bill averts government shutdown

175. Errors in the Huntington’s disease gene accumulate slowly and then all at once

176. The early origins of bone-tool manufacturing traditions by hominins 1.5 million years ago

177. Fossilized dinosaur cells that defied the ravages of time — 20 years since a key discovery

178. Strong, flexible ‘nylon’ made by engineered bacteria for the first time

179. How I connect Colombia’s remote communities to safer water

180. How a PhD travel fellowship enriched an international cell-biology meeting

181. ‘Science is happening’: Israeli and Palestinian scientists continue collaborations amid conflict

182. The untamed river and the Moog: Books in brief

183. Author Correction: B-cell-specific checkpoint molecules that regulate anti-tumour immunity

184. How researchers can work fairly with Indigenous and local knowledge

185. A radical manifesto for truth

186. Don’t wait out four hard years: speak truth to power

187. I spent two years organizing an international conference. How do I get compensated for my work?

188. Stay safe from online hate with these five tips

189. ‘My career is over’: Columbia University scientists hit hard by Trump team’s cuts

190. How extreme lethargy can promote healthy ageing

191. A century of quantum physics

192. Your lab pollutes: here’s how to stop it

193. Daily briefing: Should the Stanford Prison Experiment be retracted more than fifty years on?

194. Saturn has a whopping 274 moons ― scientists want to know why

195. Why it makes sense for wealthier nations to help others decarbonize

196. Will RFK Jr’s vaccine agenda make American contagious again?

197. Mega-storm dumps 11 billion tonnes of snow ― and builds up a melting ice sheet

198. Man survives with titanium heart for 100 days – a world first

199. These frustrated scientists want to leave the United States – do you? Take Nature’s poll

200. Daily briefing: Saturn has 128 new moons

201. Did Mars harbour life? One of the strongest signs yet is spotted in a peculiar rock

202. How fast your brain ages is affected by these 64 genes

203. Fresh ‘quantum advantage’ claim made by computing firm D-Wave

204. Metals squeezed to thickness of just two atoms

205. Biodiversity declines across fragmented forests

206. Ancient DNA shows Stone Age Europeans voyaged by sea to Africa

207. An operating system for networked quantum computers is a huge practical step forward

208. The brain’s building blocks for understanding social interactions

209. Immune molecule links COVID‑19 with severe inflammatory disorder in children

210. Move over graphene! Scientists forge bismuthene and host of atoms-thick metals

211. An archaic European face more than one million years old

212. Liver cancer recurrence predicted by immune-cell location and gene expression

213. An ultra-broadband photonic-chip-based parametric amplifier

214. Dual neuromodulatory dynamics underlie birdsong learning

215. Sliding and healing of frictional interfaces that appear stationary

216. High continuity of forager ancestry in the Neolithic period of the eastern Maghreb

217. Unconventional magnons in collinear magnets dictated by spin space groups

218. Increasing hourly heavy rainfall in Austria reflected in flood changes

219. Spatial immune scoring system predicts hepatocellular carcinoma recurrence

220. Structure and mechanism of the plastid/parasite ATP/ADP translocator

221. Basis functions for complex social decisions in dorsomedial frontal cortex

222. Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

223. Magnetically and optically active edges in phosphorene nanoribbons

224. Large recoverable elastic energy in chiral metamaterials via twist buckling

225. Natural behaviour is learned through dopamine-mediated reinforcement

226. MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC

227. Record sea surface temperature jump in 2023–2024 unlikely but not unexpected

228. Adaptive locomotion of active solids

229. The earliest human face of Western Europe

230. Species turnover does not rescue biodiversity in fragmented landscapes

231. Realization of 2D metals at the ångström thickness limit

232. A robustly rooted tree of eukaryotes reveals their excavate ancestry

233. An operating system for executing applications on quantum network nodes

234. TGFβ links EBV to multisystem inflammatory syndrome in children

235. Perception of viral infections and initiation of antiviral defence in rice

236. Genomic determinants of antigen expression hierarchy in African trypanosomes

237. High temporal variability not trend dominates Mediterranean precipitation

238. Weather anomalies cannot explain insect decline

239. Sapphire anvils squeeze metals atomically-thin

240. Watch DeepMind’s AI robot slam-dunk a basketball

241. Reply to: Weather anomalies cannot explain insect decline

242. Daily briefing: NASA begins mass firings of scientists

243. Elisabeth Vrba obituary: palaeontologist who solved a problem that vexed Darwin

244. So you’ve made a lab website. What should go on it?

245. Robotic fingers can tell objects apart by touch

246. Medical records from the Center for the Study of Temporal Disorders, Pediatric Department

247. Author Correction: Observation of Nagaoka polarons in a Fermi–Hubbard quantum simulator

248. Why are proponents of ‘smart cities’ neglecting research?

249. Four ways COVID changed virology: lessons from the most sequenced virus of all time

250. Bad romance: male octopuses inject deadly venom into their mates

251. Author Correction: Transforming a head direction signal into a goal-oriented steering command

252. Complex water networks visualized by cryogenic electron microscopy of RNA

253. Preprint sites bioRxiv and medRxiv launch new era of independence

254. NASA begins mass firings of scientists ahead of Trump team’s deadline

255. An organ that stores red blood cells for emergencies

256. Author Correction: Classification with a disordered dopant atom network in silicon

257. Public-health experts should be more political, not less

258. Alcohol and cancer risk: what you need to know

259. Daily briefing: Thousands protest Trump cuts at #StandUpForScience rallies

260. For more reliable AI, academics should edit Wikipedia

261. COP30 must deliver binding mechanisms to address climate change, not empty promises

262. Similar chiral phenomena occur in cell cultures and human crowds

263. Fate of pistachio production in Iran holds lessons for the world

264. How a vast digital twin of the Yangtze River could prevent flooding in China

265. How the NIH dominates the world’s health research — in charts

266. I create buildings from mushroom components

267. Are microplastics bad for your health? More rigorous science is needed

268. Daily briefing: This key protein could be responsible for brain ageing

269. The ‘quantum’ principle that says why atoms are as they are

270. #ScientistAtWork 2025: Nature is seeking stunning photographic images that capture researchers’ working lives

271. Our experience of teaching neuroscience in a maximum-security prison

272. Science diplomacy can help to heal global rifts — if research is respected

273. ‘Scientists will not be silenced’: thousands protest Trump research cuts

274. Who’s likely to wake up from a coma? Brain waves provide a clue

275. The surprising culprit for the loss of huge swathes of tropical forest

276. How a PhD student’s lab size affects their chance of future academic success

277. ‘I was told to toughen up’: is academia getting resilience all wrong?

278. Rock hunters, tree huggers and taxi drivers: Books in brief

279. Author Correction: Warming and cooling catalyse widespread temporal turnover in biodiversity

280. AI tools are spotting errors in research papers: inside a growing movement

281. Microsoft quantum computing ''breakthrough'' faces fresh challenge

282. Daily briefing: The second X chromosome isn’t so silent after all

283. Unknown fate of ice-hunting Moon missions leaves scientists in suspense

284. The financial shackling of historically Black universities in the United States

285. Trans researchers under attack: LGBTQ biologists face hostile work environment

286. Foreign researchers in China face tightening restrictions

287. Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis

288. Ancient puppets that smile or scowl hint at shared rituals

289. Daily briefing: PubMed blackout stokes fears about database’s future

290. Trump''s nominee for NIH chief talks frozen grants and fostering ‘scientific dissent’

291. Exclusive: NIH to terminate hundreds of active research grants

292. Sexual harassment allegations linked to drop in citations

293. Why women’s brains are more resilient: it could be their ‘silent’ X chromosome

294. AI algorithm helps telescopes to pivot fast towards gravitational-wave sources

295. How the brain decides whether to persist — and when to give up

296. A supersolid made using photons

297. This key protein could be responsible for brain ageing

298. Protein waste turned into antibiotics as a defence strategy of human cells

299. Ancient humans used bone tools one million years earlier than thought

300. Amazonian deforestation makes the wet season wetter, and the dry season dryer