1. Black Death bacterium has become less lethal after genetic tweak

2. Rare ‘ambidextrous’ protein breaks rules of handedness

3. Forehead ‘e-tattoo’ tracks how hard you’re thinking

4. How a freezing pond could kick-start life''s self-replication

5. Mouse liver assembloids model periportal architecture and biliary fibrosis

6. How the natural world is inspiring the robot eyes of the future

7. Researchers who ‘pivot’ into new fields should not be given a citation penalty

8. Daily briefing: Chemical ‘shuttles’ carry large drugs across the blood-brain barrier

9. First Chinese mission to sample an asteroid starts its journey

10. Trump’s call for ‘gold standard science’ has prompted an outcry: here’s why

11. Molecular blueprint of a cellular sorting centre

12. Shifting research focus comes with the risk of reduced impact

13. Light reflects as a vortex off a metamaterial with unusual optical properties

14. How the brain spies on the gut: with help from newfound immune cells

15. The ‘pivot penalty’: scientists get cited less after switching fields, analysis finds

16. Reverse electron transport drives metabolic changes in obesity

17. Origins of the ‘vampire fungus’ that causes white-nose syndrome in bats

18. Electrical switching of a p-wave magnet 

19. Domesticated cannabinoid synthases amid a wild mosaic cannabis pangenome

20. Global dominance of seasonality in shaping lake-surface-extent dynamics

21. The history and future of resting-state functional magnetic resonance imaging

22. The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour

23. The pivot penalty in research

24. Dynamic basal ganglia output signals license and suppress forelimb movements

25. EndoMAP.v1 charts the structural landscape of human early endosome complexes

26. Unconventional solitonic high-temperature superfluorescence from perovskites

27. Light-triggered regionally controlled n-doping of organic semiconductors

28. Dating the evolution of oxygenic photosynthesis using La-Ce geochronology

29. In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking

30. Air pollution modulates trends and variability of the global methane budget

31. The shaping of terrestrial planets by late accretions

32. Radiative forcing reduced by early twenty-first century increase in land albedo

33. Preoptic EP3R neurons constitute a two-way switch for fever and torpor

34. Astrocyte morphogenesis requires self-recognition

35. Two distinct host-specialized fungal species cause white-nose disease in bats

36. Detection of X-ray emission from a bright long-period radio transient

37. CoQ imbalance drives reverse electron transport to disrupt liver metabolism

38. Cross-tissue multicellular coordination and its rewiring in cancer

39. AI linked to boom in biomedical papers, infrared contact lenses, and is Earth’s core leaking?

40. Pt migration-lockup in zeolite for stable propane dehydrogenation catalyst

41. Protein-primed homopolymer synthesis by an antiviral reverse transcriptase

42. Electricity-driven enzymatic dynamic kinetic oxidation

43. Singapore’s fight to save its green spaces from development

44. Bed bugs boomed as the world’s first cities did

45. The perfect storm for dust storms, thanks to global warming

46. ‘A funeral for our careers’: Trump’s science cuts spill onto Canadian turf

47. Archaeology field notebook

48. Daily briefing: Harvard has had nearly 1,000 research grants cancelled

49. Europe can capture the US brain drain — if it acts fast

50. Brain drugs can now cross the once impenetrable blood–brain barrier

51. Observing anyonization of bosons in a quantum gas

52. A coordinated cellular network regulates tolerance to food

53. The diet crazes of the nineteenth century

54. Fake AI images will cause headaches for journals

55. End racism in science: there shouldn’t be any argument about this goal

56. Time-management skills I honed as a PhD student now serve me well in industry

57. ‘Science saved my life’ — and it must save other at-risk scholars

58. Cancer-fighting immune cells could soon be engineered inside our bodies

59. Daily briefing: Contact lenses give people infrared vision

60. Gripping account of psychology’s cautionary tale is marred by flawed assumptions

61. Global measles eradication goal is urgently needed

62. The forest space age needs eyes on the ground

63. Address academic bullying through structural reform

64. Taking common medicines might matter for cancer treatment

65. Scaling and logic in the color code on a superconducting quantum processor

66. Hong Kong universities woo Harvard international students targeted by Trump

67. Scientists with ADHD speak up: when fire meets focus

68. These contact lenses let humans see invisible infrared light

69. Landmark air-pollution lab under threat from Trump cuts — can it be saved?

70. Harvard researchers devastated as Trump team cuts nearly 1,000 grants

71. Why do hailstones get so big? Scientists are chasing storms to find answers

72. The Last of Us science adviser: COVID changed our appetite for zombies

73. Author Correction: Chromosome end protection by RAP1-mediated inhibition of DNA-PK

74. I didn’t find AI useful. Then I let it teach me to code

75. A walk down memory lane and other stirring stories: Books in brief

76. I apply my aquatic-science training to empower Tanzania’s seaweed farmers

77. Daily briefing: Earth’s core could be leaking

78. How artificial intelligence is transforming pathology

79. How to delight your future boss at a science job interview

80. This ancient pathogen became deadlier when humans started wearing wool

81. Rare ‘spider star’ spotted consuming its companion

82. Publisher Correction: Imaging surface structure and premelting of ice Ih with atomic resolution

83. ‘Landmark’ evolution study shows how rice inherits tolerance to cold without DNA changes

84. These contact lenses give people infrared vision — even with their eyes shut

85. Signatures of chiral superconductivity in rhombohedral graphene

86. Nations urged to ‘pick up the ball’ after DEI research cuts

87. Scientific conferences are leaving the US amid border fears

88. ‘Powerful and horrifying’ — David Attenborough’s latest film is a cry to protect our oceans

89. AI listens for health conditions

90. Why space exploration must not be left to a few powerful nations

91. How and when North America’s deepest river gorge formed

92. Don’t feel the pain — these brain cells help with managing opioid withdrawal

93. Author Correction: Global methane emissions from rivers and streams

94. Author Correction: A human brain map of mitochondrial respiratory capacity and diversity

95. Daily briefing: ‘I used AI to design an awful protein’

96. Author Correction: Structure and topography of the synaptic V-ATPase–synaptophysin complex

97. Publisher Correction: Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis

98. Publisher Correction: Multi-zonal liver organoids from human pluripotent stem cells

99. NIH killed grants on orders from Elon Musk’s DOGE

100. Is Earth’s core leaking? Volcanic rocks provide strongest evidence yet

101. Sequence diversity lost in early pregnancy

102. Mice lacking this amino acid lost 30% of their body weight

103. Under the microscope: DNA damage tracked through cell generations

104. Patterns of DNA modifications provide a ‘barcode’ for cell-lineage tracing

105. Projections of Earth’s health under different environmental policies

106. The evolutionary origin of sensitive dental structures

107. Dying stars give a second wind to exoplanet formation

108. How axolotl cells ‘remember’ development to rebuild a lost limb

109. The path for AI in poor nations does not need to be paved with billions

110. Early barred galaxy raises questions about cosmic evolution

111. Antimalarial-treated bed nets could stop parasites developing in mosquitoes

112. The origin of vertebrate teeth and evolution of sensory exoskeletons

113. Unexpected clustering pattern in dwarf galaxies challenges formation models

114. In vivo screen of Plasmodium targets for mosquito-based malaria control

115. Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor

116. Molecular basis of positional memory in limb regeneration

117. PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer

118. Ru and W isotope systematics in ocean island basalts reveals core leakage

119. Multigenerational cell tracking of DNA replication and heritable DNA damage

120. A foundation model for the Earth system

121. Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1

122. C-to-N atom swapping and skeletal editing in indoles and benzofurans

123. Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity

124. The structure of liquid carbon elucidated by in situ X-ray diffraction

125. Closed-loop vagus nerve stimulation aids recovery from spinal cord injury

126. Quasar radiation transforms the gas in a merging companion galaxy

127. Large gas inflow driven by a matured galactic bar in the early Universe

128. Programmable control of spatial transcriptome in live cells and neurons

129. Clonal tracing with somatic epimutations reveals dynamics of blood ageing

130. A retrograde planet in a tight binary star system with a white dwarf

131. Unravelling cysteine-deficiency-associated rapid weight loss

132. These malaria drugs treat the mosquitoes — not the people

133. AI linked to explosion of low-quality biomedical research papers

134. The Age of Reason

135. Before studying parasites, this PhD researcher was their host

136. #OpenToWork: how laid-off US scientists are coping with shattered careers

137. Daily briefing: What a precious handful of fossils is teaching us about Denisovans

138. Are groundbreaking science discoveries becoming harder to find?

139. What big eyes this whale has — but not the better to see you with

140. Explosive volcanoes can bury carbon —a climate boon

141. Telescope team reads the fine print — from more than a kilometre away

142. Bird-flu vaccine for cattle aces early test

143. How much ultra-processed food do you eat? Blood and urine record it

144. Trump’s cuts to international aid are stifling Africa’s HIV research

145. Science’s ‘Gollum effect’: PhDs bear brunt of territorial behaviour

146. NSF plan to slash ‘indirect’ science funding: will it stick?

147. One-carbon homologation of alkenes

148. Turning the tide on ocean conservation

149. I told AI to make me a protein. Here’s what it came up with

150. Does lightning make trees swish?

151. Richard Garwin obituary: designer of the hydrogen bomb who advocated for arms control

152. Philanthropic funders: team up to jump-start innovative science

153. Author Correction: Earth’s ambipolar electrostatic field and its role in ion escape to space

154. Who were the ancient Denisovans? Fossils reveal secrets about the mysterious humans

155. Daily briefing: The world’s first human bladder transplant

156. How ‘organized looting and plunder’ drove Britain’s second scientific revolution

157. Don’t forget the lessons of the McCarthy era

158. Data resources must be protected from political interference

159. AI-generated literature reviews threaten scientific progress

160. AI bots threaten online scientific infrastructure

161. Mother–infant bonds in wild chimpanzees resemble those of humans

162. Author Correction: Inhibitory specificity from a connectomic census of mouse visual cortex

163. Author Correction: Soft–hard zwitterionic additives for aqueous halide flow batteries

164. AI tool flags people at high risk of postpartum depression

165. AI is more persuasive than people in online debates

166. Genomics reveals zoonotic and sustained human Mpox spread in West Africa

167. World first: ultra-powerful CRISPR treatment trialled in a person

168. Exclusive: NIH grant rejections have more than doubled amid Trump chaos

169. People and dogs team up to protect sea turtles in Cabo Verde

170. Hurricane risk in a changing climate — the role of uncertainty

171. When the government cancels your research grant, here’s what you can do

172. Daily briefing: Meet the baby who received the world’s first personalized CRISPR therapy

173. Mighty microbes — the invisible forces that can save the world

174. ‘Minimalist’ quantum computer simulates movements of molecules

175. Can AI help us talk to dolphins? The race is now on

176. Daily briefing: Yes, you can find love during your PhD

177. Atacama sunshine helps to pull water from thin air

178. Can NIH-funded research on racism and health survive Trump’s cuts?

179. US brain drain: Nature’s guide to the initiatives drawing scientists abroad

180. The world’s richest people have an outsized role in climate extremes

181. How CAR-T cancer therapies could harm the brain

182. Powerful CRISPR system inserts whole gene into human DNA

183. World’s first personalized CRISPR therapy given to baby with genetic disease

184. Stem cells coaxed into most advanced amniotic sacs ever grown in the lab

185. Ku limits RNA-induced innate immunity to allow Alu-expansion in primates

186. AI language models develop social norms like groups of people

187. Seeking a job in science? How hiring practices across industry and academia compare

188. Daily briefing: These award-winning photos show scientists at work

189. Daily briefing: Five secrets of super-healthy seniors

190. PhD students in STEM: Nature wants to hear from you

191. Dear editors, your publication delays are damaging our careers

192. Mice grow bigger brains when given this stretch of human DNA

193. Earth’s climatic past illuminates future South Asian monsoon patterns

194. Marsupial embryos lack the epigenetic reset seen in placental mammals

195. Genomes from a four-generation family reveal the rate of new mutations

196. DeepMind unveils ‘spectacular’ general-purpose science AI

197. Track record: unexpectedly early reptile claw prints found

198. Black hole flings out clumps of gas

199. Black hole fly-by modelled with landmark precision

200. Immune control of metastatic cancer at the edge of the central nervous system

201. Fossil claw marks show reptiles arose far earlier than thought

202. ‘I don’t have the bandwidth’: how to juggle dating alongside a PhD

203. Thermal asymmetry in the Moon’s mantle inferred from monthly tidal response

204. Prefrontal encoding of an internal model for emotional inference

205. Water ice in the debris disk around HD 181327

206. Dopaminergic action prediction errors serve as a value-free teaching signal

207. Emergence of Calabi–Yau manifolds in high-precision black-hole scattering

208. Unconventional domain tessellations in moiré-of-moiré lattices

209. Solid phase transitions as a solution to the genome folding paradox

210. Spatial transcriptomics reveals human cortical layer and area specification

211. Oncogenic fusions converge on shared mechanisms in initiating astroblastoma

212. Quantum error correction of qudits beyond break-even

213. Genome diversity and signatures of natural selection in mainland Southeast Asia

214. Tunable vacuum-field control of fractional and integer quantum Hall phases

215. Systems consolidation reorganizes hippocampal engram circuitry

216. Interferon-γ orchestrates leptomeningeal anti-tumour response

217. Bulk–spatiotemporal vortex correspondence in gyromagnetic zero-index media

218. STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity

219. Targeting symbionts by apolipoprotein L proteins modulates gut immunity

220. Ultrahigh-pressure crystallographic passage towards metallic hydrogen

221. Wireless transmission of internal hazard signals in Li-ion batteries

222. Earliest amniote tracks recalibrate the timeline of tetrapod evolution

223. Chicago Archaeopteryx informs on the early evolution of the avian bauplan

224. A human-specific enhancer fine-tunes radial glia potency and corticogenesis

225. Divergent DNA methylation dynamics in marsupial and eutherian embryos

226. Proton transport from the antimatter factory of CERN

227. Encapsulated Co–Ni alloy boosts high-temperature CO2 electroreduction

228. Taurine from tumour niche drives glycolysis to promote leukaemogenesis

229. Radiation-induced amphiregulin drives tumour metastasis

230. Exploring pathways for world development within planetary boundaries

231. Past warm intervals inform the future South Asian summer monsoon

232. Structured ionized winds shooting out from a quasar at relativistic speeds

233. How to transport antimatter — stick it on the back of a van

234. The visitors

235. Do look up: how science and international cooperation closed the ozone hole

236. Brain tissues, assemble! Inside the push to build better brain models

237. Take Nature’s AI research test: find out how your ethics compare

238. Is it OK for AI to write science papers? Nature survey shows researchers are split

239. Six striking images showcase scientific fieldwork

240. Nature project to encourage early-career researchers in peer review is working

241. US brain drain: the scientists seeking jobs abroad amid Trump’s assault on research

242. What an angry exchange with a reviewer taught me about arrogance and humility

243. Where do comets come from?

244. My PhD adviser was fired and I was collateral damage. I learnt how to build resilience into graduate school

245. Author Correction: Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

246. Daily briefing: Chimp societies drum to a distinct beat

247. US researchers must stand up to protect freedoms, not just funding

248. Do universities serve their community?

249. Empower communities to fight climate change at grassroots level

250. ‘Loss and damage fund’ for climate change needs broader remit

251. China needs to deal with discarded electric-vehicle batteries

252. NSF terminates huge number of grants and stops awarding new ones

253. Migraine drug is first to tackle debilitating early symptoms

254. ‘AI models are capable of novel research’: OpenAI’s chief scientist on what to expect

255. North America’s birds are declining where they should be thriving

256. What language do bats speak? I’m trying to find out

257. Why bad philosophy is stopping progress in physics

258. Scientists turn lead into gold

259. Hunting extreme microbes that redefine the limits of life

260. The scars of war last for centuries: how we understand collective trauma needs to change

261. Daily briefing: How skunk cabbages get their stink

262. A ‘hidden gem’ of the Amazon is a frog with odd habits

263. Rice paddies produce food for billions ― and lots of methane

264. China’s dementia incidence is rising fast ― outpacing the global average

265. US environmental agency halts funding for its main science division

266. Google AI better than human doctors at diagnosing rashes from pictures

267. How political attacks could crush the mRNA vaccine revolution

268. ‘Orwellian’: planetary scientists outraged over deletion of research records

269. Author Correction: 2023 summer warmth unparalleled over the past 2,000 years

270. Physicists turn lead into gold — for a fraction of a second

271. A pope, a polymath and plucky women: Books in brief

272. Daily briefing: How we taste sweetness

273. Exclusive: documents reveal how NIH will axe climate studies

274. How skunk cabbages and other smelly plants brew their foul odour

275. Renewal of NIH grants linked to more innovative results, study finds

276. How quickly do humans mutate? Four generations help answer the question

277. Guess how much of the ocean floor humans have explored

278. P hacking — Five ways it could happen to you

279. Daily briefing: A spinal tumour was removed through a person’s eye socket for the first time

280. Curiosity, drive, willingness to learn: three qualities to display at science job interviews

281. Microbe that infests hospitals can digest medical-grade plastic ― a first

282. Detailed mouse brain map created with off-the-shelf microscope

283. How climate change will burden our children: data reveal a lifetime of extreme heat

284. Trump freezes ‘gain of function’ pathogen research ― threatening all US virology, critics say

285. Author Correction: Matrix-producing neutrophils populate and shield the skin

286. Brain tissue artificially expanded to show how neurons wire together

287. Time for adults to finally act like adults on climate change

288. Uncovering a key enzyme opens possible therapeutic avenues for lysosomal diseases

289. Lipid-degrading small molecule kills cancer cells by ferroptosis

290. How we taste sweetness: long-sought structure of human receptor mapped at last

291. Superb starlings swap helper and breeder roles with kin and non-kin

292. Blocking a key node in cancer signalling unlocks therapeutic potential

293. Engineered bacteria can degrade five wastewater pollutants at the same time

294. Climate risk for younger generations is set to soar

295. Chromatin loops are an ancestral hallmark of the animal regulatory genome

296. A cryptic role for reciprocal helping in a cooperatively breeding bird

297. Motor learning refines thalamic influence on motor cortex

298. Nasal vaccines for respiratory infections

299. Activation of lysosomal iron triggers ferroptosis in cancer

300. Deep origin of eukaryotes outside Heimdallarchaeia within Asgardarchaeota