1. ‘Congress has your back’: US senators tell scientists they want to protect NIH budget

2. India to penalize universities with too many retractions

3. I could not have become an astronomer on my own

4. mRNA vaccines for HIV trigger strong immune response in people

5. Potato, tomahto: the roots of the modern tater

6. Intricate origins of ice mummy’s ink revealed

7. The ocean''s deepest animal ecosystem

8. ‘Wind droughts’ driven by climate change put green power at risk

9. Google AI model mines trillions of images to create maps of Earth ‘at any place and time’

10. Daily briefing: What does quantum mechanics mean anyway?

11. My AI chatbot thinks my idea is fundable

12. How allergens make us cough and weeze — by poking holes in airway cells

13. SMART tool builds proteins on cell surfaces

14. Lava planets’ atmospheres give away what lies beneath

15. AI expands the repertoire of CRISPR-associated proteins for genome editing

16. ‘Smart’ tool pieces together proteins in response to combinations of cell-surface cues

17. Inflammation during viral infection can rouse dormant cancer cells

18. Observation of elusive interaction between neutrinos and atomic nuclei

19. Cloud-motion data identify changes in atmospheric circulation

20. Allergy-triggering proteins share a common characteristic

21. The tiny mouse lemur could make for a mighty model organism

22. Changes in Mars’s habitability could have been driven by carbonate formation and transient oases

23. Laser beams programmed to form various shapes by nanodisk arrays

24. Miniature neutrino detector promises to test laws of physics

25. Chemicals seeping from the sea floor sustain an extreme-depth ecosystem

26. ‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu

27. Epithelial cell membrane perforation induces allergic airway inflammation

28. Mouse lemur cell atlas informs primate genes, physiology and disease

29. Design of highly functional genome editors by modelling CRISPR–Cas sequences

30. SuFEx-based antitubercular compound irreversibly inhibits Pks13

31. Tropical response to ocean circulation slowdown raises future drought risk

32. Diffusing protein binders to intrinsically disordered proteins

33. Towards more effective nature-based climate solutions in global forests

34. Securing the forest carbon sink for the European Union’s climate ambition

35. Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in early life

36. A molecular cell atlas of mouse lemur, an emerging model primate

37. Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry

38. Respiratory viral infections awaken metastatic breast cancer cells in lungs

39. ACLY inhibition promotes tumour immunity and suppresses liver cancer

40. Invariance of dynamo action in an early-Earth model

41. Direct observation of coherent elastic antineutrino–nucleus scattering

42. Programmable protein ligation on cell surfaces

43. A hypothalamic circuit that modulates feeding and parenting behaviours

44. Synthesis of bulk hexagonal diamond

45. Remodelling of corticostriatal axonal boutons during motor learning

46. Repurposing haemoproteins for asymmetric metal-catalysed H atom transfer

47. Flourishing chemosynthetic life at the greatest depths of hadal trenches

48. Earth''s deepest ecosystem discovered six miles below the sea

49. Retraction Note: Parkin and PINK1 mitigate STING-induced inflammation

50. Powerful satellite will chart changes on Earth’s surface in exquisite detail — down to a centimetre

51. Things I miss about civilization

52. Author Correction: Dendritic, delayed, stochastic CaMKII activation in behavioural time scale plasticity

53. Physicists disagree wildly on what quantum mechanics says about reality, Nature survey shows

54. Physicists should revel in the diversity of ways to understand quantum mechanics

55. Author Correction: Dual interfacial H-bonding-enhanced deep-blue hybrid copper–iodide LEDs

56. Sleuths and scientific institutions are not rivals

57. Scientific bedlam at the world’s weirdest and wildest research conference

58. Daily briefing: The brain deploys immune cells at the mere sight of sickness

59. From bench to big boss: mitigating the widening gap between PI and lab

60. Cell''s sugar coating mapped at below-nanometre resolution

61. Scientists mourn Tom Lehrer — nerdiest of singer-songwriters

62. Columbia researchers eager to restart science after university’s deal with Trump

63. Could machine learning help to build a unified theory of cognition?

64. The Virtual Lab of AI agents designs new SARS-CoV-2 nanobodies

65. The quest to detect consciousness — in all its possible forms

66. Can science address painters’ problems?

67. AI models are neglecting African languages — scientists want to change that

68. Africa needs to invest in science communication — here’s how

69. Could bridging science and the arts be the key to better policies?

70. The brain fires up immune cells when sick people are nearby

71. Daily briefing: Ageing accelerates after 50 — but not all organs age at the same rate

72. How China’s bold talent recruitment has shaped science

73. China reins in the spiralling construction costs of nuclear power — what can other countries learn?

74. Artificial diamonds are forever: 70 years of synthesizing these iconic gems

75. Daily briefing: ‘Arsenic life’ paper retracted after 15 years — against its authors’ will

76. ‘For AI to change how economies work, it has to represent all of us’

77. How I’m helping to develop more-resilient food systems

78. Why space foods aren’t just for space

79. Physicists unleashed the power of the atom — but to what end?

80. Hard paths: how courage differs from bravery in science

81. Postdocs get more equipment time when applications are anonymized

82. Mystery food in Neanderthal diet might be maggots

83. Author Correction: Immune evasion through mitochondrial transfer in the tumour microenvironment

84. How to tackle research misconduct: survey finds stark disagreement

85. Ageing accelerates around age 50 ― some organs faster than others

86. Author Correction: Human HDAC6 senses valine abundancy to regulate DNA damage

87. Daily briefing: Damaging the climate could violate international law, court rules

88. Meet the early career scientists planning to leave the United States

89. Unexpected danger lurks in this giant fault in the Yukon

90. Controversial ‘arsenic life’ paper retracted after 15 years — but authors fight back

91. Spain bids 400 million to host mega telescope at risk in US budget cuts

92. I won three competitive grants in a row. Here’s how I learnt what to do

93. DeepMind and OpenAI models solve maths problems at level of top students

94. This fish-inspired suction cup can stick to your organs

95. Daily briefing: Scans reveal that optimists share similar brain-activity patterns

96. Researchers in dismay as US exits world science body UNESCO . . . again

97. The deep sea is a globally connected habitat

98. Solid gold superheated to 14 times its melting temperature

99. Meet Aeneas: the AI that can fill in the gaps of damaged Latin texts

100. AI for Latin inscriptions supplies missing text and predicts date and location

101. Superheated gold stays solid well past its predicted melting point

102. Missing steps uncovered in a pathway plants use to produce the defence molecule salicylic acid

103. Unusual fossil skin appendage is not a feather

104. Molecule eases neurological symptoms of mitochondrial deficiency in coenzyme Q10

105. Global hotspots of mycorrhizal fungal richness are poorly protected

106. Superheating gold beyond the predicted entropy catastrophe threshold

107. Complete biosynthesis of salicylic acid from phenylalanine in plants

108. The neural basis of species-specific defensive behaviour in Peromyscus mice

109. Structural variation in 1,019 diverse humans based on long-read sequencing

110. A generic non-invasive neuromotor interface for human-computer interaction

111. Spatiotemporal faunal connectivity across global sea floors

112. Driving a protective allele of the mosquito FREP1 gene to combat malaria

113. Eye structure shapes neuron function in Drosophila motion vision

114. Coherent spectroscopy with a single antiproton spin

115. Mechanical underwater adhesive devices for soft substrates

116. Deciphering phenylalanine-derived salicylic acid biosynthesis in plants

117. Hippocampal representations drift in stable multisensory environments

118. Contextualizing ancient texts with generative neural networks

119. Integrated biotechnological and AI innovations for crop improvement

120. A gut sense for a microbial pattern regulates feeding

121. Magnon spectroscopy in the electron microscope

122. Triassic diapsid shows early diversification of skin appendages in reptiles

123. Precisely defining disease variant effects in CRISPR-edited single cells

124. Humoral determinants of checkpoint immunotherapy

125. NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity

126. Complex genetic variation in nearly complete human genomes

127. Three-step biosynthesis of salicylic acid from benzoyl-CoA in plants

128. Nanobody therapy rescues behavioural deficits of NMDA receptor hypofunction

129. Reply to: Experiments implementing small commuting models lack gravitational features

130. Giant laser heats solid gold to 14 times its melting point

131. Experiments implementing small commuting models lack gravitational features

132. Pre-rRNA spatial distribution and functional organization of the nucleolus

133. Daily briefing: The restaurant at the centre of the mathematical universe

134. The last parliament

135. Lethal malaria parasite’s weaknesses revealed

136. There’s a new acid in our rain — should we be worried?

137. Protect the integrity of the US National Institutes of Health

138. Ageing stem cells in the knees drive arthritis damage

139. Rumble in the Miocene: terror bird versus caiman

140. Do academics publish less after getting tenured? Depends on your field

141. Researchers value null results, but struggle to publish them

142. People’s brains aged faster during the COVID pandemic — even the uninfected

143. Breaking point: mechanical stress helps NINJ1 protein to rupture membranes

144. Help save 2 million lives: close the vaccine funding gap

145. The optimistic brain: scans reveal thought patterns shared by positive thinkers

146. A natural nuclear reactor

147. Author Correction: Stress dynamically modulates neuronal autophagy to gate depression onset

148. Author Correction: Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer

149. The COVID-19 pandemic transformed this scientist into a research-integrity sleuth

150. How I’m advocating in Congress for the next generation of US scientists

151. Fund scholars who tackle urgent issues — from misinformation to error spotting

152. Made-to-order DNA goes big: new tech doubles size of custom genetic sequences

153. China is boosting its Antarctic research. What does that mean for the world?

154. Daily briefing: NASA staff speak out against Trump cuts

155. Brazil must not weaken environmental planning rules

156. Encouraging a ‘data sufficiency’ mindset is key for responsible research

157. Why publishing referee reports could backfire on public trust

158. China’s fossil-fuel challenge — how to build a bridge to renewables

159. ‘Immortal’ stars have an elixir of youth: dark matter

160. AI, bounties and culture change, how scientists are taking on errors

161. Budget brainwaves: low-cost system collects brain data outside the lab

162. How AI can deepen inequities for non-native English speakers in science

163. Biggest trial of four-day work week finds workers are happier and feel just as productive

164. Solving aviation’s climate-action conundrum

165. Scientific jargon can be ‘satisfying’ — but misleading

166. ‘We dissent’: NASA staff declare opposition to Trump cuts

167. Daily briefing: How the brain boots up from sleep to wakefulness

168. ‘We have less than ten minutes’: how I communicate with spacecraft from the ground

169. Meet the biotech-company founders driven by their child’s rare disease

170. Why evaluating the impact of AI needs to start now

171. Should we treat rivers as living things?

172. How your research can survive a US federal grant termination

173. Sex at birth is not always random — mum’s age and genetics can play a part

174. Asia’s haze affects ice and weather on the Frozen Continent

175. Pathology-oriented multiplexing enables integrative disease mapping

176. This ancient mega-predator was built for stealth

177. Should I tell anyone that I suspect misconduct in a paper I’m reviewing?

178. Class of 2025: five PhD students reveal realigned priorities in wake of COVID and cuts

179. Daily briefing: The birth of a solar system caught ‘on camera’ for the first time

180. To the Moon and quack: Books in brief

181. Google tapped billions of mobile phones to detect quakes worldwide — and send alerts

182. AI and misinformation are supercharging the risk of nuclear war

183. How to avoid nuclear war in an era of AI and misinformation

184. How sugar overload in early life affects the brain later

185. How the world’s biggest bats got their enormous wingspans

186. Robots demonstrate principles of collective intelligence

187. Heart from organ donor restarted outside the body — technique offers new source of organs

188. ‘Controlled chaos’: how to create an environment that fosters genius

189. How the brain wakes up from sleep — and produces that morning feeling

190. Daily briefing: The breakthrough proof bringing mathematics closer to a grand unified theory

191. ‘Landmark’ study: three-person IVF leads to eight healthy children

192. ‘Another DeepSeek moment’: Chinese AI model Kimi K2 stirs excitement

193. Liquid–liquid interfacial tension stabilized Li-metal batteries

194. ‘Stealth flippers’ helped this extinct mega-predator stalk its prey

195. Birds use a tiny RNA fragment to balance sex chromosomes

196. Giant study finds a research field that’s mostly reproducible

197. Plant immune receptor engineered to protect against more than 100 viruses

198. Super-resolution spectroscopy with ‘spiky’ X-ray lasers

199. Birth of a solar system caught ‘on camera’ for first time

200. Genome doubling fuels ovarian cancer evolution and immune dysregulation

201. Gut bacteria make a molecule that promotes plaque build-up in arteries

202. The origin of the oldest solid objects in the Solar System

203. Human activity redistributes nitrogen fixation across the terrestrial biosphere

204. Star flares when an orbiting planet gets too close

205. Prophages block cell surface receptors to preserve their viral progeny

206. Global terrestrial nitrogen fixation and its modification by agriculture

207. Observation of charge–parity symmetry breaking in baryon decays

208. Refractory solid condensation detected in an embedded protoplanetary disk

209. Biphasic liquids with shape-shifting and bistable microdomains

210. Detecting structural heart disease from electrocardiograms using AI

211. Functional regimes define soil microbiome response to environmental change

212. Longer scans boost prediction and cut costs in brain-wide association studies

213. Dual interfacial H-bonding-enhanced deep-blue hybrid copper–iodide LEDs

214. Adaptations for stealth in the wing-like flippers of a large ichthyosaur

215. Remodelling autoactive NLRs for broad-spectrum immunity in plants

216. Long-range hyperbolic polaritons on a non-hyperbolic crystal surface

217. Non-antibiotics disrupt colonization resistance against enteropathogens

218. Identification of medication–microbiome interactions that affect gut infection

219. Ongoing genome doubling shapes evolvability and immunity in ovarian cancer

220. Dynamic kinetic resolution of phosphines with chiral supporting electrolytes

221. Mitochondrial origins of the pressure to sleep

222. Super-resolution stimulated X-ray Raman spectroscopy

223. Neutrophils drive vascular occlusion, tumour necrosis and metastasis

224. Immigrant–native pay gap driven by lack of access to high-paying jobs

225. A male-essential miRNA is key for avian sex chromosome dosage compensation

226. Imidazole propionate is a driver and therapeutic target in atherosclerosis

227. Redox-powered autonomous directional C–C bond rotation under enzyme control

228. Temperature-Related Hospitalization Burden under Climate Change

229. Author Correction: BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

230. Punchlines for peace

231. How a bipolar diagnosis benefits my research

232. How to de-Americanize global science

233. The breakthrough proof bringing mathematics closer to a grand unified theory

234. The mysterious missing ingredient in the highest-energy cosmic rays

235. Low-quality papers based on public health data are flooding the scientific literature

236. One potent gene raises risk of Alzheimer’s, Parkinson’s and other brain diseases

237. Without science, there can be no development

238. A canine friend to a feline family

239. Monster black hole merger is biggest ever seen

240. Why the global economy is more uncertain than ever, and what to do about it

241. Daily briefing: A new blood group has been discovered — and only one person has it

242. Bring science into business schools to train the leaders of tomorrow

243. Critical commentaries such as ‘Matters arising’ have flawed formats

244. China’s journal ranking system stands up to scrutiny

245. Invest in data resources to make FAIR a reality

246. Map endemic species before they vanish unrecorded

247. Smart brain-zapping implants could revolutionize Parkinson’s treatment

248. Embattled US scientific society names palaeontologist to top job

249. Exclusive: NIH to dismiss dozens of grant reviewers to align with Trump priorities

250. Why do ageing rates vary by country? Massive study says politics play a part

251. Found: a human gut microbe that makes cancer therapy more effective in mice

252. Microbiota-driven antitumour immunity mediated by dendritic cell migration

253. Experimental demonstration of logical magic state distillation

254. Why I study trauma''s genetic legacy

255. Daily briefing: The true nature of Greenland’s unique sled dogs revealed by centuries-old DNA

256. Need to update your data? Follow these five tips

257. A motorcycle ride through the forest: how I protect Nigeria’s wildlife

258. China’s shift towards ‘organized research’: how can coordination and innovation co-exist?

259. Publisher Correction: Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin

260. AI hype, crackling northern lights and more: take it all in with these holiday reads

261. Giant radio telescope was ‘a natural magnet’ for African talent

262. Scientists everywhere must be protected

263. Scientists hide messages in papers to game AI peer review

264. Lonely spacecraft can navigate the stars

265. Three weeks in a hide to spot one elusive bear: the life of a wildlife film-maker

266. Mini hearts, lungs and livers made in lab now grow their own blood vessels

267. Author Correction: Adhesive anti-fibrotic interfaces on diverse organs

268. Daily briefing: Research sleuthing is being ‘twisted’ to cast doubt on science

269. US senators poised to reject Trump’s proposed massive science cuts

270. Centuries-old DNA reveals origins of Greenland’s unique dogs

271. Survey of US postdocs finds threefold increase in job losses

272. Giant map details nerves across a mouse''s body: see stunning pics

273. Promising vaccine against deadly Nipah virus can also treat infection

274. Daily briefing: The first malaria treatment for babies wins approval

275. Author Correction: Spatial immune scoring system predicts hepatocellular carcinoma recurrence

276. Author Correction: Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3

277. Extreme river flood exposes latent erosion risk

278. OpenAI''s o3 tops new AI league table for answering scientific questions

279. Research is powered by technical talent — and recognition is finally on the rise

280. Symbolic ‘science fair’ showcases research cut by Trump team

281. Workouts can help gut microbes to quell cancer

282. The curious case of how bird wrists evolved

283. Enormous inventory of plastic chemicals could shape safer future use

284. Ancient proteins rewrite the rhino family tree — are dinosaurs next?

285. Nanoplastics make up most of the plastic pollutants in the North Atlantic Ocean

286. Plastics pollution is surging — the planned UN treaty to curb it must be ambitious

287. Highly efficient air filter inspired by mucus-covered nasal hair

288. Animal diseases leapt to humans when we started keeping livestock

289. Integrated cryogenic chip controls spin qubits

290. Millions of tonnes of nanoplastics are polluting the ocean

291. Weight loss alters adipose tissue beyond just reducing fat

292. First returned rock samples shine a light on the Moon’s ‘dark side’

293. Reorganization of the theropod wrist preceded the origin of avian flight

294. Single nuclear spin detection and control in a van der Waals material

295. Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy

296. Nanoplastic concentrations across the North Atlantic

297. Synthesis of deuterated acids and bases using bipolar membranes

298. Moiré materials based on M-point twisting

299. Quantum correlations of spontaneous two-photon emission from a quantum dot

300. Eighteen million years of diverse enamel proteomes from the East African Rift